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How long does Sustol work to prevent chemotherapy nausea?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on April 18, 2023.

Official answer


Sustol (generic name: granisetron) has a polymer-based drug delivery system to maintain therapeutic levels of granisetron for 5 days or longer, covering both the acute and delayed phases of chemotherapy-induced nausea and vomiting (CINV).

Sustol is an extended-release, injectable 5-HT3 antagonist for the prevention of CINV due to certain cancer treatments. Sustol is used together with other anti-nausea medications. It is given as an injection under your skin by your healthcare provider.

Sustol is administered on Day 1 of chemotherapy. Do not use more frequently than once every 7 days because of the extended-release properties of the medicine.

Related: How is Sustol given? (in more detail)

This is not all the information you need to know about Sustol for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Sustol information here, and discuss this information and any questions you have with your doctor or other health care provider.


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