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User Reviews for Zofran ODT

Zofran ODT has an average rating of 7.4 out of 10 from a total of 46 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 24% reported a negative effect.

Condition Avg. Rating Reviews Compare
Nausea/Vomiting  
7.1
42 reviews 159 medications
Nausea/Vomiting, Chemotherapy Induced  
10.0
2 reviews 57 medications
Gastroenteritis  Off-label
10.0
1 reviews 22 medications
Nausea/Vomiting, Postoperative  
10.0
1 reviews 13 medications
Summary of Zofran ODT reviews 7.4 46 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Zofran ODT

Pickled · Taken for 1 to 2 years April 20, 2021

For Nausea/Vomiting: “This medication makes me more nauseous than before taking it. After 3 surgeries and multiple nausea filled days due to a chronic health condition, I’ve concluded that this drug makes things worse for me. I kept hoping it was all in my head, but other anti nausea meds (and even peppermint) work almost immediately, at least to a certain extent. Whereas this always makes me 10x worse to the point of vomiting. It also gives me really bad headaches and I don’t ever get headaches in general. It’s the only medication that gives me this side effect. So I think this either works very well for people, or makes it worse. I’m wondering if it has to do with brain chemistry since it’s a serotonin blocker? I’m severely ADHD with mild OCD and depression. Perhaps certain brain wiring just doesn’t benefit. I’d love more research to be done on this since it’s the standard anti nausea treatment given in hospitals.”

1 / 10
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Anonymous · Taken for less than 1 month April 20, 2013

For Nausea/Vomiting: “I've been taking ondansetron ODT 8mg tabs for about 2 days due to nausea caused by a kidney infection. When I take the tablet it doesn't help and makes me more nauseous than I was before. I just took it a half hour ago to be sure, and I immediately became more nauseous. So I'm pretty sure it just doesn't work for me, and I'm wondering if anyone else has this problem?”

2 / 10
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Catstone · Taken for less than 1 month February 22, 2021

For Nausea/Vomiting: “Horrible drug for me. Actually makes me nauseous and throw up. Nothing tastes right on this medication. One dose had me throwing up and nauseous, not able to eat for a couple days. One dose had me constipated for about 5 days before I was back to normal (with taking stool softeners Rx after surgery). May work for some but for me it’s a NO go.”

1 / 10
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Artemis Black October 23, 2014

For Nausea/Vomiting: “Zofran completely changed my life! The ODT are perfect because I suffer from anxiety and sometimes it gets so bad that I begin to vomit. Also, with Irritable Bowel Syndrome it helps control the nausea and vomiting associated with it. I get no side effects but my insurance doesn't cover more than 5 tabs at a time so I have to get it in regular pill form sometimes at Costco where they have the cheapest price.”

10 / 10
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Ginger · Taken for 6 months to 1 year February 4, 2021

For Nausea/Vomiting: “I have extreme anxiety which causes me to have stomach issues to be constantly nauseous. I love this medication but the only side effect I have is constipation but I usually just take a Senakot or just eat the Fiber 1 bars. It works quickly. Doesn't taste the best but absolutely worth it”

10 / 10
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Cindy Halloween June 11, 2021

For Nausea/Vomiting: “I’ve been using Zofran for a couple years after it was given to me in the hospital for nausea, following surgery. It has always worked beautifully in combatting those days when I or a friend have felt nauseated. But the last time I took one , in February, during the night when awakened by stomach pain and nausea, it actually made things worse by adding an immediate head ache, and extreme heart palpitations..that lasted a good half hour, with out helping my initial nausea at all. I’ve been afraid to use it ever since. Turns out I was experiencing a gallbladder attack, and I’m not certain that wasn’t the reason the Zofran failed. Today, I’m having one of those icky nauseated days, two doses of Emetrol have not helped, so I took a Zofran and cut it in half, yes, they are already small, but I was nervous. Im happy to report, it seems to have worked. Nausea is nearly gone now. No headache, no increased heart rate. I'm hoping Zofran is once more my friend.”

7 / 10
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Cara22 · Taken for less than 1 month June 14, 2013

For Nausea/Vomiting: “I have been very sick and vomiting with my 2nd pregnancy. My doctor prescribed this to me and now I can keep food and liquids down. I can actually get out of bed and play with my 2yr old. It has saved me.”

10 / 10
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Frequently asked questions

Uniqua · Taken for less than 1 month February 3, 2016

For Nausea/Vomiting: “Today I went to the doctors for some common flu symptoms. They prescribed me Zofran for my nausea and upset stomach. About 10-15 minutes after taking it there was a tremendous relief of everything. It works rapidly and does wonders. I have not experienced any side effects like headaches or nothing yet so everything's good so far.”

10 / 10
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Wildflowersma September 23, 2013

For Nausea/Vomiting: “I suffer from chronic lower back pain due to scoliosis and arthritis (42 yrs old). I also suffer from Irritable Bowel Syndrome. I take Zofran almost daily to deal with the miseries of both lower back pain and digestive issues. I still have regular bouts of vomiting, however, Zofran will stop the pain and nausea that would continue for days and land me in the hospital with an IV delivering morphine into my system to stop the cycle of vomiting, nausea, and severe pain. I love my Zofran! It makes life "livable."”

10 / 10
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carrielynn29 February 2, 2008

For Nausea/Vomiting: “My doctor prescribed this to me for pregnancy induced nausea and vomiting. All of my pregnancys were horrible with nausea and vomiting. Well this time Im about seven weeks pregnant and I have been taking the generic brand onadosterone orrally distinguishing tablets, they are small with a minty flavor. It melts quickly and I must say I have not vomited one time this pregnancy. I have had mild tiredness, headache, dizziness and much better than nausea and vomiting and being unable to eat.”

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Nuggw March 28, 2013

For Nausea/Vomiting: “Went into the ER for the stomach flu. I had been sick for 4 days without eating a thing. I was severely dehydrated and was fainting. They gave me I.V and a dissolve-able pill of Ondansetron (4mg). I was finally able to stop vomiting after 4 days. I still can't eat other than broth but thankfully the vomiting stopped.”

8 / 10
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Anonymous April 7, 2008

For Nausea/Vomiting: “My mother was down to 78lbs.due to nausea.Phenergan had been the only drug her Dr.would prescribe. This continued for 3 months until someone told me about zofran. I asked if we could please try it, it was amazing.I'm positive,if we hadn't asked about this drug,she would be dead from starvation ,due to nausea.”

10 / 10
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Mrs. Grayson January 11, 2013

For Nausea/Vomiting: “I have severe nausea and vomiting due to an extreme case of endometriosis. I have to be hospitalized because of pain, weakness and dehydration because of severe vomiting. I can't even hold down a tiny sip of water for 2 mins. I have tried every medication possible and Zofran ODT is the only thing that gives me relief! It is a prescription I always have on hand at all times.”

10 / 10
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cat1962 October 1, 2010

For Nausea/Vomiting: “I was given this in the ER when I went in with nausea/vomiting problems. I've taken a couple of the 4mg tabs since I've been home and they work great. Problem is that I only was prescribed 5 tabs and I'm having trouble getting more. I suffer from anxiety and am feeling nauseous on a daily basis. I also think this is pre-menopausal nausea since I've suffered from gastric problems in the past. Hoping to get more. Don't want to have to take it but I sure want it available to me.”

9 / 10
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Anonymous · Taken for less than 1 month August 20, 2012

For Nausea/Vomiting: “Whole family in hospital for stomach virus with severe nausea and vomiting every half hour. This medicine completely stops the nausea within minutes! It definitely gives you headaches and makes you sleepy, but this is a small price to pay to stop the nausea when you are in that situation. ”

10 / 10
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Anonymous April 5, 2010

For Nausea/Vomiting: “I must say I don't have cancer, and I don't have a disease, I have a spas mastic colon which in turns gives me a severe case of Irritable Bowel Syndrome with Constipation. I usually have a bowl movement every 6-11 days and when I do, I get extremely ill with uncontrollable vomiting due to the pain. I've tried several NON dissolving medications and I've found that Zofran ODT (8mg) is the best and I will stick with it as long as it continues to work for me. I hope someone finds this helpful. If you have any form of illness that causes severe vomiting I recommend Zofran ODT.”

10 / 10
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silvergirlsdca · Taken for 1 to 6 months September 18, 2012

For Nausea/Vomiting: “I am pregnant and have been suffering from severe nausea and vomiting. I have been taking Zofran for about 25 weeks. The disolving tablet doesn't have an affect on me. I can't keep it down, even after half an hour I will throw up the medication. The rare times I can hold it down, it has no affect on me.”

2 / 10
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EGSJEM January 8, 2009

For Nausea/Vomiting: “The medicine saved my second pregnancy (with twins). It enabled me to eat normally most of the time although I did have a bit of nausea. There was no adverse effect on my twins - both are healthy 18 months later. Great drug.”

10 / 10
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housemaid · Taken for less than 1 month December 17, 2014

For Nausea/Vomiting: “I had this in the hospital after a hysterectomy when I was vomiting from the anesthesia for 3 days afterward. It did absolutely nothing to stop my nausea. I was given it repeatedly even though I told them it was completely ineffective. I had both shots and pills.”

1 / 10
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Miss Birdie · Taken for less than 1 month September 20, 2015

For Nausea/Vomiting: “Had kidney stone and given a Zofran prescription to take home for nausea - it only made it worse. Every time I took it I found myself more nauseous after only 1/2 hour. I chose to stop and had my doctor switch me to a different drug. I think some people's systems are more sensitive to it than others, especially if they are taking pain medications with the Zoran.”

1 / 10
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Little C. · Taken for less than 1 month December 12, 2016

For Nausea/Vomiting: “I was rxed the ODT for extreme nausea and vomiting, due to a norovirus. The minty flavor really drove me over the edge, and only made matters worse. Then my doc gave me the regular tablets that you swallow with a tiny bit of water, but it didn't help at all, either. I remember being awed by the knowledge that they give this med to sick cancer patients, when it is so horribly ineffective. Evidently, it does work like gangbusters for some people, but I'm not one of them.”

1 / 10
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SadGrace · Taken for 1 to 6 months April 20, 2016

For Nausea/Vomiting: “I feel like I've been sick for a very long time. It began around early February. I started feeling tired and nauseous. I had other symptoms, but the nausea was the worst. It just got worse and more frequent. My mother talked me into going in and I was diagnosed with "migraine with aura" about a month ago. I don't feel like migraines have anything to do with the nausea, but that's all I have to go on for now. The nausea comes in waves and I've had to stop doing schoolwork because of it. I was hoping the zofran would help, but it doesn't seem to do anything. I still wake up at night because I'm so nauseous, and it never seems to end.”

1 / 10
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Oakley Girl 2 August 2, 2017

For Nausea/Vomiting: “I take Zofran ODT to relieve the severe medication withdrawal symptoms I experience when I accidentally miss a dose of my prescribed daily medication. Severe medication withdrawal symptoms such as brain zaps, nausea, vomiting, headaches, and dizziness. ”

10 / 10
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Tls570 · Taken for 6 months to 1 year April 6, 2018

For Nausea/Vomiting: “I get debilitating migraines that cause vomiting, and I have several GI issues, my doctor ordered zofran pills to begin with and they did nothing for me. Although I still feel a little nauseous at times I can stop the vomiting with the zofran ODT by putting it under my tongue.”

8 / 10
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Anonymous March 6, 2012

For Nausea/Vomiting: “I was pregnant and had severe morning sickness. I was throwing 7-10 a day on a good day. With the Zofran I was down to once or maybe twice a day. I was able to eat and drink liquids again. The chalky flavor does get to you after an extended period of time.”

7 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.