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Sucralfate Side Effects

For the Consumer

Applies to sucralfate: oral suspension, oral tablet

As well as its needed effects, sucralfate may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking sucralfate, check with your doctor immediately:

Signs of aluminum toxicity
  • Drowsiness
  • convulsions (seizures)

Minor Side Effects

Some sucralfate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Constipation
Less common or rare:
  • Backache
  • diarrhea
  • dizziness or lightheadedness
  • dryness of mouth
  • indigestion
  • nausea
  • skin rash, hives, or itching
  • stomach cramps or pain

For Healthcare Professionals

Applies to sucralfate: compounding powder, oral suspension, oral tablet


The most commonly reported side effect was constipation.[Ref]


Common (1% to 10%): Constipation
Uncommon (0.1% to 1%): Dry mouth, nausea
Rare (0.01% to 0.1%): Bezoar formation
Frequency not reported: Diarrhea, vomiting, gastric discomfort, indigestion, flatulence
Postmarketing reports: Lip swelling, mouth edema[Ref]

Bezoars were reported in patients with enteral feedings, delayed gastric emptying, and/or low birthweight neonates.[Ref]

Nervous system

Encephalopathy occurred in patients with chronic renal impairment and/or on long-term treatment.

Cerebral emboli occurred in patients receiving IV administration.[Ref]

Common (1% to 10%): Headache
Frequency not reported: Dizziness, drowsiness/sleepiness, vertigo, encephalopathy
Postmarketing reports: Cerebral emboli[Ref]


Uncommon (0.1% to 1%): Urticaria
Rare (0.01% to 0.1%): Rash
Frequency not reported: Pruritus[Ref]


Osteodystrophy and osteomalacia occurred in patients with chronic renal impairment and/or on long-term treatment.[Ref]

Frequency not reported: Back pain, osteodystrophy, osteomalacia[Ref]


Frequency not reported: Anaphylactic reaction, hypersensitivity reactions[Ref]


Pulmonary edema occurred after IV administration.[Ref]

Frequency not reported: Dyspnea
Postmarketing reports: Bronchospasm, laryngeal edema, pharyngeal edema, respiratory tract edema, pulmonary emboli[Ref]


Frequency not reported: Thirst
Postmarketing reports: Face edema[Ref]


Anemia occurred in patients with chronic renal impairment and/or on long-term treatment.[Ref]

Frequency not reported: Anemia[Ref]


Frequency not reported: Insomnia[Ref]


Frequency not reported: Hyperglycemia[Ref]


Frequency not reported: Edema[Ref]


1. "Product Information. Carafate (sucralfate)." Hoechst Marion-Roussel Inc, Kansas City, MO.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of sucralfate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.