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Ritalin LA Side Effects

Generic name: methylphenidate

Medically reviewed by Drugs.com. Last updated on Apr 30, 2024.

Note: This document provides detailed information about Ritalin LA Side Effects associated with methylphenidate. Some dosage forms listed on this page may not apply specifically to the brand name Ritalin LA.

Applies to methylphenidate: oral capsule extended release, oral capsule extended release biphasic 30/70, oral capsule extended release biphasic 40/60, oral capsule extended release biphasic 50/50, oral powder for suspension extended release, oral solution, oral tablet, oral tablet chewable, oral tablet extended release, oral tablet extended release chewable, oral tablet extended release disintegrating.

Other dosage forms:

Important warnings This medicine can cause some serious health issues

Oral route (tablet, extended release, disintegrating)

Warning: Abuse, Misuse, and Addiction. Methylphenidate have a high potential for abuse and misuse, which can lead to the development of a substance use disorder, including addiction.

Misuse and abuse of CNS stimulants, including methylphenidate, can result in overdose and death, and this risk is increased with higher doses or unapproved methods of administration, such as snorting or injection.

Before prescribing methylphenidate, assess each patient’s risk for abuse, misuse, and addiction.

Educate patients and their families about these risks, proper storage of the drug, and proper disposal of any unused drug.

Throughout methylphenidate treatment, reassess each patient’s risk of abuse, misuse, and addiction and frequently monitor for signs and symptoms of abuse, misuse, and addiction

Oral route (tablet, extended release chewable; capsule, extended release; tablet; tablet, extended release; solution; powder for suspension, extended release)

Abuse, Misuse, and Addiction. Methylphenidate hydrochloride has a high potential for abuse and misuse, which can lead to the development of a substance use disorder, including addiction.

Misuse and abuse of CNS stimulants, including methylphenidate hydrochloride, can result in overdose and death, and this risk is increased with higher doses or unapproved methods of administration, such as snorting or injection.Before prescribing methylphenidate hydrochloride, assess each patient’s risk for abuse, misuse, and addiction.

Educate patients and their families about these risks, proper storage of the drug, and proper disposal of any unused drug.

Throughout methylphenidate hydrochloride treatment, reassess each patient’s risk of abuse, misuse, and addiction and frequently monitor for signs and symptoms of abuse, misuse, and addiction.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

You or your child will also need to have your blood pressure and heart rate measured before starting this medicine and while you are using it. If you notice any change in your blood pressure, call your doctor right away. If you have questions about this, talk to your doctor.

You or your child should not use this medicine if you are using or have used a drug for depression, called an MAO inhibitor (MAOI), such as Eldepryl®, Marplan®, Nardil®, or Parnate®, within the past 14 days.

Methylphenidate may cause dizziness, drowsiness, or changes in vision. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Methylphenidate may cause serious heart or blood vessel problems. This may be more likely in patients who have a family history of heart disease. Check with your doctor right away if you or your child has chest pain, trouble breathing, fainting, or a fast, irregular heartbeat while using this medicine.

Tell your doctor right away if you or your family notice any unusual changes in behavior, including an increase in aggression, hostility, agitation, irritability, or suicidal thinking or behaviors. Also tell your doctor if you feel, see, or hear things that are not there, or have any unusual thoughts, especially if they are new or getting worse quickly.

This medicine may cause slow growth and weight loss. If your child is using this medicine, the doctor will need to keep track of his height and weight to make sure that he is growing properly.

Methylphenidate may cause a condition called Raynaud's phenomenon. Check with your doctor right away if you or your child has tingling or pain in the fingers or toes when exposed to cold temperatures, paleness or a cold feeling in the fingertips and toes, or a skin color change in your fingers.

Make sure any doctor or dentist who treats you knows that you are using Metadate CD®, Relexxii®, Ritalin®, Ritalin LA®, or Ritalin-SR®. You may need to stop using this medicine before you have surgery.

Avoid drinking alcohol while using Concerta®, Cotempla XR-ODT™ extended release disintegrating tablets, Adhansia XR®, Aptensio XR™, Metadate CD®, or Ritalin LA® extended-release capsules, Quillichew ER™ extended-release chewable tablets, or Quillivant® XR extended-release suspension.

If you or your child experience a prolonged or painful erection of the penis for more than 4 hours, check with your doctor right away.

Adhansia XR® contains a yellow dye called tartrazine, which may cause severe allergic reactions. Tell your doctor if you have any allergies (including an aspirin allergy).

Symptoms of overdose include: agitation, blurred vision, change in consciousness, chest pain or discomfort, confusion, dark urine, diarrhea, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, fever, headache, inability to speak, loss of consciousness, muscle cramps, spasms, pain, or stiffness, nausea, nervousness, overactive reflexes, pain or discomfort in the arms, jaw, back, or neck, pale, clammy skin, palpitations, pounding in the ears, seeing, hearing, or feeling things that are not there, seizures, shivering, slow or fast heartbeat, slurred speech, sweating, talking or acting with excitement you cannot control, temporary blindness, thirst, trembling or shaking, trouble breathing, unusual tiredness or weakness, vomiting, or weakness in the arm or leg on one side of the body, sudden and severe. Call your doctor right away if you notice these symptoms.

If you have been using this medicine for a long time and you think you may have become mentally or physically dependent on it, check with your doctor right away. Some signs of dependence may include:

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines, herbal or vitamin supplements, and medicine for appetite control, asthma, colds, cough, hayfever, or sinus problems.

Serious side effects of Ritalin LA

Along with its needed effects, methylphenidate (the active ingredient contained in Ritalin LA) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methylphenidate:

More common side effects

  • fast heartbeat

Less common side effects

  • chest pain
  • fever
  • joint pain
  • skin rash or hives

Rare side effects

  • black, tarry stools
  • blood in the urine or stools
  • blurred vision or other changes in vision
  • crusting, dryness, or flaking of the skin
  • muscle cramps
  • pinpoint red spots on the skin
  • scaling, severe redness, soreness, or swelling of the skin
  • seizures
  • uncontrolled vocal outbursts or tics (uncontrolled and repeated body movements)
  • unusual bleeding or bruising

Incidence not known

  • agitation
  • arm, back or jaw pain
  • bleeding gums
  • bloody nose
  • chest discomfort, tightness, or heaviness
  • chills
  • clenching, gnashing, or grinding teeth
  • confusion
  • cough
  • dark urine
  • decreased interest in sexual intercourse
  • diarrhea
  • difficulty with speaking
  • difficulty with swallowing
  • discouragement
  • dizziness
  • double vision
  • drowsiness
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • feeling like surroundings are not real
  • feeling sad or empty
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • headache
  • heavier menstrual periods
  • inability to have or keep an erection
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • irritability
  • itching skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss in sexual ability, desire, drive, or performance
  • loss of interest or pleasure
  • mood swings
  • muscle pain, stiffness, or spasms
  • nausea
  • nervousness
  • numbness of the hands
  • overactive reflexes
  • painful or difficult urination
  • pale skin
  • paleness or cold feeling in the fingertips and toes
  • poor coordination
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, irritated eyes
  • red, swollen, or scaly skin
  • redness, soreness, or itching skin
  • restlessness
  • right upper stomach tenderness
  • seeing, hearing, or feeling things that are not there
  • severe or sudden headache
  • shivering
  • slow speech
  • slowed growth in children
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stuffy or runny nose
  • sudden loss of coordination
  • sudden slurring of speech
  • sweating
  • swollen glands
  • talking or acting with excitement you cannot control
  • tingling or pain in the fingers or toes when exposed to cold temperatures
  • trembling or shaking
  • tremor
  • trouble concentrating
  • trouble sleeping
  • trouble breathing
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unusual behavior
  • unusual tiredness or weakness
  • weight loss
  • yellow skin or eyes

Get emergency help immediately if any of the following symptoms of overdose occur while taking methylphenidate:

Symptoms of overdose

Other side effects of Ritalin LA

Some side effects of methylphenidate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • loss of appetite
  • stomach pain

Less common side effects

  • acid or sour stomach
  • anger
  • belching
  • fear
  • heartburn
  • indigestion
  • irritability
  • scalp hair loss
  • stomach discomfort or upset
  • vomiting

For healthcare professionals

Applies to methylphenidate: oral capsule extended release, oral powder for reconstitution extended release, oral solution, oral tablet, oral tablet chewable, oral tablet chewable extended release, oral tablet disintegrating extended release, oral tablet extended release, transdermal film extended release.

General adverse events

The more commonly reported adverse reactions have included decreased appetite, abdominal pain, nausea, vomiting, dyspepsia, insomnia, weight loss, anxiety, dizziness, irritability, affect lability, tachycardia, and increased blood pressure.[Ref]

Other

Psychiatric

Metabolic

Gastrointestinal

Nervous system

Endocrine

Respiratory

Musculoskeletal

Among patients 7 to 10 years old, consistently medicated (i.e., receiving methylphenidate for 7 days per week) for over 14 months, as well as in naturalistic subgroups of newly methylphenidate-treated patients over 36 months (ages of 10 to 13 years), a temporary slowing in growth rate (on average, a total of about 2 cm less growth in height and 2.7 kg less growth in weight over 3 years), has been observed compared to non-medicated patients. This slowing in growth rate has been observed without evidence of growth rebound.[Ref]

Local

Cardiovascular

Dermatologic

Immunologic

Ocular

Genitourinary

Hepatic

Hypersensitivity

Hematologic

See also:

References

1. (2022) "Product Information. Metadate CD (methylphenidate)." Celltech Pharmaceuticals Inc

2. (2002) "Product Information. Metadate ER (methylphenidate)." Celltech Pharmaceuticals Inc

3. (2002) "Product Information. Concerta (methylphenidate)." Alza

4. Cerner Multum, Inc. "UK Summary of Product Characteristics."

5. Cerner Multum, Inc. "Australian Product Information."

6. (2013) "Product Information. Quillivant XR (methylphenidate)." NextWave Pharmaceuticals

7. (2019) "Product Information. Cotempla XR-ODT (methylphenidate)." Neos Therepeautics, Inc

8. (2019) "Product Information. Methylin (methylphenidate)." Mallinckrodt Medical Inc

9. (2019) "Product Information. Adhansia XR (methylphenidate)." Adlon Therapeutics

10. (2019) "Product Information. Daytrana (methylphenidate)." Noven Pharmaceuticals, Inc.

11. (2019) "Product Information. Jornay PM (methylphenidate)." Ironshore Pharmaceuticals Inc.

12. (2001) "Product Information. Ritalin (methylphenidate)." Novartis Pharmaceuticals

Frequently asked questions

Further information

Ritalin LA side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.