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Quillivant XR

Generic Name: methylphenidate (oral) (METH il FEN i date)
Brand Names: Aptensio XR, Concerta, Cotempla XR-ODT, Metadate CD, Metadate ER, Methylin, QuilliChew ER, Quillivant XR, Ritalin

Medically reviewed on August 15, 2018

What is Quillivant XR?

Quillivant XR (methylphenidate) is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Quillivant XR extended-release oral suspension is used to treat attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD). The extended-release oral suspension formulation releases methylphenidate into your body throughout the day.

Quillivant XR may help increase attention and decrease impulsiveness and hyperactivity in patients with ADHD.

Important Information

You should not use Quillivant XR if you have glaucoma, tics or Tourette's syndrome, or severe anxiety, tension, or agitation.

Do not use Quillivant XR if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Methylphenidate may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder.

Methylphenidate may be habit-forming, and this medicine is a drug of abuse. Tell your doctor if you have had problems with drug or alcohol abuse.

Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect.

You may have blood circulation problems that can cause numbness, pain, or discoloration in your fingers or toes.

Call your doctor right away if you have: signs of heart problems - chest pain, feeling light-headed or short of breath; signs of psychosis - paranoia, aggression, new behavior problems, seeing or hearing things that are not real; signs of circulation problems - unexplained wounds on your fingers or toes.

Before taking this medicine

Do not use Quillivant XR if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use Quillivant XR if you are allergic to methylphenidate, or if you have:

Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have:

  • heart problems or a congenital heart defect;

  • high blood pressure; or

  • a family history of heart disease or sudden death.

To make sure Quillivant XR is safe for you, tell your doctor if you or anyone in your family has ever had:

  • depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;

  • motor tics (muscle twitches) or Tourette's syndrome;

  • blood circulation problems in the hands or feet;

  • seizures or epilepsy;

  • problems with the esophagus, stomach, or intestines;

  • an abnormal brain wave test (EEG); or

  • drug or alcohol addiction.

It is not known whether Quillivant XR will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Quillivant XR is not approved for use by anyone younger than 6 years old.

How should I take Quillivant XR?

Take Quillivant XR extended-release oral suspension exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Methylphenidate may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

For patients 6 years and above, recommended starting dose of Quillivant XR 25 mg/5 mL extended-release oral suspension is 20 mg (4 mL) given orally once daily in the morning. Dosage may be increased weekly in increments of 10 mg (2 mL) to 20 mg (4 mL) per day. Daily dosage above 60 mg (12 mL) is not recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask the doctor or pharmacist if you have any questions.

Quillivant XR extended-release oral suspension can be taken with or without food. Follow the directions on the medicine label

Dosing Instructions

  • Remove the Quillivant XR bottle and oral dosing dispenser from the box. If the oral dosing dispenser is missing or not provided, please contact your pharmacist for a replacement;

  • Check and make sure that the Quillivant XR bottle contains liquid medicine. If the medicine still in powder form, do not use it. Return it to your pharmacist;

  • Shake the bottle well (up and down) for at least 10 seconds before each use;

  • Uncap the bottle and check that the bottle adapter has been inserted into the bottle;

  • If bottle adapter has not been inserted into the bottle, insert adapter into the bottle;

  • Once the bottle adapter has been inserted into the bottle, it should not be removed. If the bottle adapter has not been inserted and is missing from the box, contact your pharmacist;

  • Check the Quillivant XR dose in milliliters (mL) as prescribed by your doctor. Locate this number on the oral dosing dispenser;

  • Insert the tip of the oral dosing dispenser into the upright bottle and push the plunger all the way down;

  • With the oral dosing dispenser in place, turn the bottle upside down. Pull the plunger to the number of mL you need;

  • Measure the number of mL of medicine from the white end of the plunger;

  • Remove the oral dosing dispenser from the bottle adapter;

  • Slowly squirt Quillivant XR directly into your or your child's mouth;

  • Cap the bottle tightly. Store the bottle upright at 59°F to 86°F (15°C to 30°C);

  • Clean the oral dosing dispenser after each use by placing in the dishwasher, or by rinsing with tap water.

To prevent sleep problems, take Quillivant XR in the morning.

While using Quillivant XR, your doctor will need to check on progress at regular visits. Your or your childs heart rate, blood pressure, height and weight may also need to be checked often.

From time to time, the doctor may stop Quillivant XR treatment for a while to check ADHD symptoms.

If you need surgery, tell the surgeon ahead of time that you are using Quillivant XR. You may need to stop using the medicine for a short time.

Keep track of the amount of medicine used from each new bottle. Methylphenidate is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Quillivant XR dosing information

Usual Adult Dose of Quillivant XR for Attention Deficit Disorder:

Initial Dose: 20 mg orally once a day in the morning before breakfast.
Maintenance Dose: Doses may be increased weekly in increments of 10 mg to 20 mg up to a maximum of 60 mg once daily in the morning.
Comments: Vigorously shake for at least 10 seconds before each dose. Administer only with the dosing dispenser provided. Wash dispenser after each use (dishwasher safe).

Usual Pediatric Dose of Quillivant XR for Attention Deficit Disorder:

6 years or older: Initial Dose: 20 mg orally once a day in the morning before breakfast.
Maintenance Dose: Doses may be increased weekly in increments of 10 mg to 20 mg up to a maximum of 60 mg once daily in the morning.
Comments: Vigorously shake for at least 10 seconds before each dose. Administer only with the dosing dispenser provided. Wash dispenser after each use (dishwasher safe).

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is later than 6:00 p.m. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methylphenidate could be fatal.

What should I avoid while taking Quillivant XR?

Avoid drinking alcohol while taking Quillivant XR. Alcohol may cause your methylphenidate dose to be released into the bloodstream too fast.

See also: Quillivant XR and alcohol (in more detail)

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Quillivant XR side effects

Get emergency medical help if you have signs of an allergic reaction to Quillivant XR: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • signs of heart problems - chest pain, trouble breathing, feeling like you might pass out;

  • signs of psychosis - hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;

  • signs of circulation problems - numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;

  • a seizure (convulsions);

  • muscle twitches (tics);

  • changes in your vision; or

  • penis erection that is painful or lasts 4 hours or longer (rare).

Methylphenidate can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common Quillivant XR side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Quillivant XR?

Ask your doctor before using a stomach acid medicine (including Alka-Seltzer or sodium bicarbonate). Some of these medicines can change the way your body absorbs methylphenidate, and may increase side effects.

Many drugs can interact with methylphenidate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Quillivant XR only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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