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Quillivant XR

Generic Name: methylphenidate (oral) (METH il FEN i date)
Brand Names: Aptensio XR, Concerta, Metadate CD, Metadate ER, Methylin, Quillivant XR, Ritalin, Ritalin LA, Ritalin-SR

What is Quillivant XR?

Quillivant XR (methylphenidate) is a central nervous system (CNS) stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Quillivant XR extended-release oral suspension is used to treat attention deficit hyperactivity disorder (ADHD). The extended-release oral suspension formulation releases methylphenidate into your body throughout the day.

Quillivant XR may help increase attention and decrease impulsiveness and hyperactivity in patients with ADHD.

Important information

You should not use Quillivant XR if you have glaucoma, tics or Tourette's syndrome, or severe anxiety, tension, or agitation.

Do not use Quillivant XR if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Methylphenidate may be habit forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction.

Using Quillivant XR improperly can cause death or serious side effects on the heart.

Before taking this medicine

Do not use Quillivant XR if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use Quillivant XR if you are allergic to methylphenidate, or if you have:

  • glaucoma;

  • a personal or family history of tics (muscle twitches) or Tourette's syndrome; or

  • severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse).

Some stimulants have caused sudden death in certain people. Tell your doctor if you have:

  • heart problems or a congenital heart defect;

  • high blood pressure; or

  • a family history of heart disease or sudden death.

To make sure Quillivant XR is safe for you, tell your doctor if you or anyone in your family has ever had:

  • depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;

  • motor tics (muscle twitches) or Tourette's syndrome;

  • blood circulation problems in the hands or feet;

  • seizures or epilepsy;

  • problems with the esophagus, stomach, or intestines;

  • an abnormal brain wave test (EEG); or

  • a history of drug or alcohol addiction.

It is not known whether Quillivant XR will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether methylphenidate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Quillivant XR is not approved for use by anyone younger than 6 years old.

How should I take Quillivant XR?

Take Quillivant XR extended-release oral suspension exactly as prescribed by your doctor. Using this medicine improperly can cause death or serious side effects on the heart.

For patients 6 years and above, recommended starting dose of Quillivant XR 25 mg/5 mL extended-release oral suspension is 20 mg (4 mL) given orally once daily in the morning. Dosage may be increased weekly in increments of 10 mg (2 mL) to 20 mg (4 mL) per day. Daily dosage above 60 mg (12 mL) is not recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask the doctor or pharmacist if you have any questions.

Quillivant XR extended-release oral suspension can be taken with or without food. Follow the directions on the medicine label

Dosing Instructions

  • Remove the Quillivant XR bottle and oral dosing dispenser from the box. If the oral dosing dispenser is missing or not provided, please contact your pharmacist for a replacement;

  • Check and make sure that the Quillivant XR bottle contains liquid medicine. If the medicine still in powder form, do not use it. Return it to your pharmacist;

  • Shake the bottle well (up and down) for at least 10 seconds before each use;

  • Uncap the bottle and check that the bottle adapter has been inserted into the bottle;

  • If bottle adapter has not been inserted into the bottle, insert adapter into the bottle;

  • Once the bottle adapter has been inserted into the bottle, it should not be removed. If the bottle adapter has not been inserted and is missing from the box, contact your pharmacist;

  • Check the Quillivant XR dose in milliliters (mL) as prescribed by your doctor. Locate this number on the oral dosing dispenser;

  • Insert the tip of the oral dosing dispenser into the upright bottle and push the plunger all the way down;

  • With the oral dosing dispenser in place, turn the bottle upside down. Pull the plunger to the number of mL you need;

  • Measure the number of mL of medicine from the white end of the plunger;

  • Remove the oral dosing dispenser from the bottle adapter;

  • Slowly squirt Quillivant XR directly into your or your child's mouth;

  • Cap the bottle tightly. Store the bottle upright at 59°F to 86°F (15°C to 30°C);

  • Clean the oral dosing dispenser after each use by placing in the dishwasher, or by rinsing with tap water.

To prevent sleep problems, take Quillivant XR in the morning.

While using Quillivant XR, your doctor will need to check on progress at regular visits. Your or your childs heart rate, blood pressure, height and weight may also need to be checked often.

From time to time, the doctor may stop Quillivant XR treatment for a while to check ADHD symptoms.

If you need surgery, tell the surgeon ahead of time that you are using Quillivant XR. You may need to stop using the medicine for a short time.

Keep track of the amount of medicine used from each new bottle. Methylphenidate is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is later than 6:00 p.m. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methylphenidate could be fatal.

What should I avoid while taking Quillivant XR?

Quillivant XR may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Quillivant XR side effects

Get emergency medical help if you have signs of an allergic reaction to Quillivant XR: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Methylphenidate can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Stop taking Quillivant XR and call your doctor at once if you have:

  • chest pain, trouble breathing, feeling like you might pass out;

  • hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;

  • a seizure (convulsions);

  • numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;

  • muscle twitches (tics);

  • changes in your vision;

  • penis erection that is painful or lasts 4 hours or longer (rare); or

  • unexplained muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine).

Common Quillivant XR side effects may include:

  • feeling nervous or irritable, sleep problems (insomnia);

  • loss of appetite;

  • nausea, stomach pain; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Quillivant XR?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • medicine to treat depression or a psychiatric disorder;

  • blood pressure medication;

  • a blood thinner such as warfarin (Coumadin, Jantoven);

  • a narcotic (opioid) medication;

  • a cold or allergy medicine that contains a decongestant such as pseudoephedrine or phenylephrine; or

  • seizure medicine.

This list is not complete. Other drugs may interact with methylphenidate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Quillivant XR.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Quillivant XR only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 16.01. Revision Date: 2017-03-07, 1:38:09 PM.