Amlodipine / Perindopril Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 27, 2024.

Applies to amlodipine / perindopril: oral tablet.

Important Warnings This medicine can cause some serious health issues

Oral route (Tablet)

Discontinue as soon as pregnancy is detected.

Injury and death of the developing fetus may occur with the use of drugs that act directly on the renin-angiotensin system.

Serious side effects

Along with its needed effects, amlodipine/perindopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / perindopril:

More common

• bloating or swelling of the face, arms, hands, lower legs, or feet
• rapid weight gain
• tingling of the hands or feet
• unusual weight gain or loss

Incidence not known

• arm, back, or jaw pain
• bloody urine
• blurred vision
• chest pain or discomfort
• chest tightness or heaviness
• confusion
• decreased frequency or amount of urine
• difficult breathing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast or irregular heartbeat
• increased thirst
• irregular heartbeat
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• loss of appetite
• lower back or side pain
• nausea
• nervousness
• numbness or tingling in the hands, feet, or lips
• pain or discomfort in the arms, jaw, back or neck
• stomach pain
• sweating
• unusual tiredness or weakness
• vomiting
• weakness or heaviness of the legs

Other side effects

Some side effects of amlodipine / perindopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• cough
• dizziness
• headache

Incidence not known

• diarrhea
• rash

For Healthcare Professionals

Applies to amlodipine / perindopril: oral tablet.

General

The most common side effects were edema, cough, headache, and dizziness.^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Amlodipine:
• Common (1% to 10%): Headache, dizziness, somnolence
• Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paraesthesia, tremor, dysgeusia, postural dizziness
• Rare (0.01% to 0.1%): Amnesia, migraine
• Very rare (less than 0.01%): Hypertonia
• Frequency not reported: Extrapyramidal syndrome
• Perindopril:
• Common (1% to 10%): Headache, dizziness, drowsiness, paraesthesia, dysgeusia
• Very rare (less than 0.01%): Stroke^[Ref]

Other

• Common (1% to 10%): Edema peripheral, vertigo, fatigue, lethargy
• Amlodipine:
• Very common (10% or more): Edema peripheral (13.2%)
• Common (1% to 10%): Edema, fatigue
• Uncommon (0.1% to 1%): Vertigo, asthenia, malaise, pain, tinnitus, gynecomastia
• Rare (less than 0.1%): Ataxia
• Perindopril:
• Common (1% to 10%): Vertigo, tinnitus, asthenia
• Uncommon (0.1% to 1%): Edema peripheral, atypical chest pain
• Postmarketing reports: Falls, serositis, fever^[Ref]

Respiratory

• Common (1% to 10%): Cough, dyspnea
• Amlodipine:
• Uncommon (0.1% to 1%): Cough, dyspnea, epistaxis, rhinitis
• Rare (less than 0.1%): Parosmia
• Perindopril:
• Very common (10% or more): Cough (up to 12%)
• Common (1% to 10%): Dyspnea, epistaxis
• Uncommon (0.1% to 1%): Bronchospasm
• Very rare (less than 0.01%): Rhinitis, eosinophilic pneumonia^[Ref]

Cardiovascular

• Common (1% to 10%): Chest pain
• Uncommon (0.1% to 1%): Bradycardia, peripheral coldness
• Amlodipine:
• Common (1% to 10%): Palpitations, flushing
• Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, postural hypotension, hypotension, vasculitis
• Rare (0.01% to 0.1%): Myocardial infarction, angina pain, cardiac failure, pulse irregularity, extrasystoles, cold and clammy skin
• Perindopril:
• Common (1% to 10%): Palpitations, impaired peripheral circulation, flushing, hypotension, discomfort on exertion
• Very rare (less than 0.01%): Angina pectoris, myocardial infarction, arrhythmia, vasculitis
• Postmarketing reports: Cardiac arrest^[Ref]

Dermatologic

• Common (1% to 10%): Eczema
• Frequency not reported: Rash
• Amlodipine:
• Uncommon (0.1% to 1%): Erythema multiforme, pruritus, rash, rash erythematosus, rash maculopapular, sweating increased, purpura, alopecia, hyperhidrosis, exanthema, skin discoloration
• Rare (0.01% to 0.1%): Skin dryness, dermatitis, urticaria
• Very rare (less than 0.01%): Stevens-Johnson syndrome, exfoliative dermatitis, photosensitivity
• Perindopril:
• Common (1% to 10%): Pruritus, rash, exanthema
• Uncommon (0.1% to 1%): Hyperhidrosis, urticaria
• Very rare (less than 0.01%): Erythema multiforme
• Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea
• Frequency not reported: Nausea
• Amlodipine:
• Common (1% to 10%): Abdominal pain, nausea
• Uncommon (0.1% to 1%): Constipation, dysphagia, diarrhea, flatulence, vomiting, gingival hyperplasia, dry mouth, dyspepsia, altered bowel habits
• Rare (less than 0.1%): Loose stools, gastritis
• Perindopril:
• Common (1% to 10%): Abdominal pain, nausea, vomiting, dyspepsia, diarrhea, constipation
• Uncommon (0.1% to 1%): Dry mouth^[Ref]

Genitourinary

• Common (1% to 10%): Erectile dysfunction
• Amlodipine:
• Uncommon (0.1% to 1%): Sexual dysfunction, micturition frequency, micturition disorder, nocturia, impotence
• Rare (less than 0.1%): Dysuria
• Perindopril:
• Uncommon (0.1% to 1%): Impotence^[Ref]

Hematologic

Amlodipine:

Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Very rare (less than 0.01%): Neutropenia

Perindopril:

Uncommon (0.1% to 1%): Leukopenia

Very rare (less than 0.01%): Agranulocytosis or pancytopenia, thrombocytopenia, hemolytic anemia in patients with a congenital glucose-6-phosphate dehydrogenase deficiency, decrease in hemoglobin and hematocrit

Postmarketing reports: Anemia, leucocytosis, eosinophilia, elevated erythrocyte sedimentation rate^[Ref]

Hepatic

Amlodipine:

Uncommon (0.1% to 1%): Pancreatitis

Rare (less than 0.1%): Hepatitis, jaundice, hepatic enzyme elevations

Perindopril:

Common (1% to 10%): ALT elevated

Uncommon (0.1% to 1%): AST elevated

Rare (0.01% to 0.1%): Serum bilirubin elevated

Very rare (less than 0.01%): Pancreatitis, hepatitis

Postmarketing reports: Hepatic failure, jaundice^[Ref]

Immunologic

Amlodipine:

Uncommon (0.1% to 1%): Allergic reaction, angioedema

Very rare (less than 0.01%): Quincke's edema

Perindopril:

Uncommon (0.1% to 1%): Allergic reactions, angioedema

Postmarketing reports: Positive antinuclear antibody^[Ref]

Metabolic

• Common (1% to 10%): Hyperkalemia
• Amlodipine:
• Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst
• Rare (less than 0.1%): Increased appetite
• Perindopril:
• Frequency not reported: Hypoglycemia, hyperkalemia
• Postmarketing reports: Symptomatic hyponatremia^[Ref]

Musculoskeletal

• Frequency not reported: Joint swelling
• Amlodipine:
• Common (1% to 10%): Ankle swelling
• Uncommon (0.1% to 1%): Back pain, rigors, arthralgia, arthrosis, muscle cramps, myalgia
• Rare (less than 0.1%): Muscle weakness, twitching
• Perindopril:
• Common (1% to 10%): Back pain, muscle cramps
• Postmarketing reports: Arthralgia/arthritis, myalgia^[Ref]

Ocular

Amlodipine:

Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain, visual disturbances

Rare (less than 0.1%): Dry eyes, abnormal visual accommodation

Perindopril:

Common (1% to 10%): Visual disturbances^[Ref]

Psychiatric

Amlodipine:

Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes

Rare (less than 0.1%): Apathy, agitation, confusion

Perindopril:

Uncommon (0.1% to 1%): Mood changes, sleep disturbances

Very rare (less than 0.01%): Depression, confusion, hallucinations^[Ref]

Renal

Perindopril:

Uncommon (0.1% to 1%): Renal impairment

Very rare (less than 0.01%): Acute renal failure

Frequency not reported: Blood urea increased, serum creatinine increased

Postmarketing reports: Nephritis^[Ref]

Further information

Amlodipine/perindopril side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer