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Amlodipine / perindopril Side Effects

In Summary

Commonly reported side effects of amlodipine/perindopril include: cough. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to amlodipine / perindopril: oral tablet

In addition to its needed effects, some unwanted effects may be caused by amlodipine / perindopril. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking amlodipine / perindopril:

More common:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
Incidence not known:
  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • bloody urine
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • decreased frequency or amount of urine
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast or irregular heartbeat
  • increased thirst
  • irregular heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • lower back or side pain
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back or neck
  • sweating
  • unusual tiredness or weakness
  • weakness or heaviness of the legs

Minor Side Effects

Some of the side effects that can occur with amlodipine / perindopril may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Cough
  • dizziness
  • headache
Incidence not known:
  • Diarrhea
  • rash

For Healthcare Professionals

Applies to amlodipine / perindopril: oral tablet


The most common side effects were edema, cough, headache, and dizziness.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Common (1% to 10%): Headache, dizziness, somnolence
Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paraesthesia, tremor, dysgeusia, postural dizziness
Rare (0.01% to 0.1%): Amnesia, migraine
Very rare (less than 0.01%): Hypertonia
Frequency not reported: Extrapyramidal syndrome

Common (1% to 10%): Headache, dizziness, drowsiness, paraesthesia, dysgeusia
Very rare (less than 0.01%): Stroke[Ref]


Common (1% to 10%): Edema peripheral, vertigo, fatigue, lethargy

Very common (10% or more): Edema peripheral (13.2%)
Common (1% to 10%): Edema, fatigue
Uncommon (0.1% to 1%): Vertigo, asthenia, malaise, pain, tinnitus, gynecomastia
Rare (less than 0.1%): Ataxia

Common (1% to 10%): Vertigo, tinnitus, asthenia
Uncommon (0.1% to 1%): Edema peripheral, atypical chest pain
Postmarketing reports: Falls, serositis, fever[Ref]


Common (1% to 10%): Cough, dyspnea

Uncommon (0.1% to 1%): Cough, dyspnea, epistaxis, rhinitis
Rare (less than 0.1%): Parosmia

Very common (10% or more): Cough (up to 12%)
Common (1% to 10%): Dyspnea, epistaxis
Uncommon (0.1% to 1%): Bronchospasm
Very rare (less than 0.01%): Rhinitis, eosinophilic pneumonia[Ref]


Common (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Bradycardia, peripheral coldness

Common (1% to 10%): Palpitations, flushing
Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, postural hypotension, hypotension, vasculitis
Rare (0.01% to 0.1%): Myocardial infarction, angina pain, cardiac failure, pulse irregularity, extrasystoles, cold and clammy skin

Common (1% to 10%): Palpitations, impaired peripheral circulation, flushing, hypotension, discomfort on exertion
Very rare (less than 0.01%): Angina pectoris, myocardial infarction, arrhythmia, vasculitis
Postmarketing reports: Cardiac arrest[Ref]


Common (1% to 10%): Eczema
Frequency not reported: Rash

Uncommon (0.1% to 1%): Erythema multiforme, pruritus, rash, rash erythematosus, rash maculopapular, sweating increased, purpura, alopecia, hyperhidrosis, exanthema, skin discoloration
Rare (0.01% to 0.1%): Skin dryness, dermatitis, urticaria
Very rare (less than 0.01%): Stevens-Johnson syndrome, exfoliative dermatitis, photosensitivity

Common (1% to 10%): Pruritus, rash, exanthema
Uncommon (0.1% to 1%): Hyperhidrosis, urticaria
Very rare (less than 0.01%): Erythema multiforme
Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis[Ref]


Common (1% to 10%): Diarrhea
Frequency not reported: Nausea

Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Constipation, dysphagia, diarrhea, flatulence, vomiting, gingival hyperplasia, dry mouth, dyspepsia, altered bowel habits
Rare (less than 0.1%): Loose stools, gastritis

Common (1% to 10%): Abdominal pain, nausea, vomiting, dyspepsia, diarrhea, constipation
Uncommon (0.1% to 1%): Dry mouth[Ref]


Common (1% to 10%): Erectile dysfunction

Uncommon (0.1% to 1%): Sexual dysfunction, micturition frequency, micturition disorder, nocturia, impotence
Rare (less than 0.1%): Dysuria

Uncommon (0.1% to 1%): Impotence[Ref]


Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia
Very rare (less than 0.01%): Neutropenia

Uncommon (0.1% to 1%): Leukopenia
Very rare (less than 0.01%): Agranulocytosis or pancytopenia, thrombocytopenia, hemolytic anemia in patients with a congenital glucose-6-phosphate dehydrogenase deficiency, decrease in hemoglobin and hematocrit
Postmarketing reports: Anemia, leucocytosis, eosinophilia, elevated erythrocyte sedimentation rate[Ref]


Uncommon (0.1% to 1%): Pancreatitis
Rare (less than 0.1%): Hepatitis, jaundice, hepatic enzyme elevations

Common (1% to 10%): ALT elevated
Uncommon (0.1% to 1%): AST elevated
Rare (0.01% to 0.1%): Serum bilirubin elevated
Very rare (less than 0.01%): Pancreatitis, hepatitis
Postmarketing reports: Hepatic failure, jaundice[Ref]


Uncommon (0.1% to 1%): Allergic reaction, angioedema
Very rare (less than 0.01%): Quincke's edema

Uncommon (0.1% to 1%): Allergic reactions, angioedema
Postmarketing reports: Positive antinuclear antibody[Ref]


Common (1% to 10%): Hyperkalemia

Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst
Rare (less than 0.1%): Increased appetite

Frequency not reported: Hypoglycemia, hyperkalemia
Postmarketing reports: Symptomatic hyponatremia[Ref]


Frequency not reported: Joint swelling

Common (1% to 10%): Ankle swelling
Uncommon (0.1% to 1%): Back pain, rigors, arthralgia, arthrosis, muscle cramps, myalgia
Rare (less than 0.1%): Muscle weakness, twitching

Common (1% to 10%): Back pain, muscle cramps
Postmarketing reports: Arthralgia/arthritis, myalgia[Ref]


Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain, visual disturbances
Rare (less than 0.1%): Dry eyes, abnormal visual accommodation

Common (1% to 10%): Visual disturbances[Ref]


Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes
Rare (less than 0.1%): Apathy, agitation, confusion

Uncommon (0.1% to 1%): Mood changes, sleep disturbances
Very rare (less than 0.01%): Depression, confusion, hallucinations[Ref]


Uncommon (0.1% to 1%): Renal impairment
Very rare (less than 0.01%): Acute renal failure
Frequency not reported: Blood urea increased, serum creatinine increased
Postmarketing reports: Nephritis[Ref]


1. "Product Information. Prestalia (amLODIPine-perindopril)." Symplmed, Cincinnati, OH.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for amlodipine / perindopril may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.