Amlodipine / Perindopril Dosage
Applies to the following strength(s): 2.5 mg-3.5 mg ; 5 mg-7 mg ; 10 mg-14 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: Amlodipine 2.5 mg-Perindopril 3.5 mg orally once a day
Maximum dose: Amlodipine 10 mg-Perindopril 14 mg orally once a day
-Wait 7 to 14 days between titration steps.
-May be used as initial therapy if multiple drugs are likely needed to achieve blood pressure goals.
Renal Dose Adjustments
Mild renal dysfunction (CrCl 60 to less than 90 mL/min): Data not available
Moderate to severe renal dysfunction (CrCl less than 60 mL/min): Not recommended
Liver Dose Adjustments
US BOXED WARNING:
-FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years; not recommended in patients 65 years or older.
Consult WARNINGS section for additional precautions.
Data not available
-Assess renal function and serum electrolytes prior to initiating therapy and periodically during treatment.
-In patients at risk of excessive hypotension, initiate this drug with caution and monitor closely for the first 2 weeks and whenever the dose of this drug is increased or a diuretic is added or its dose is increased.
-Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
-In case of a missed dose, resume the usual dose at the next scheduled time.
More about amlodipine/perindopril
- Other brands: Prestalia