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Amlodipine / Perindopril Dosage

Applies to the following strength(s): 2.5 mg-3.5 mg ; 5 mg-7 mg ; 10 mg-14 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: Amlodipine 2.5 mg-Perindopril 3.5 mg orally once a day

Maximum dose: Amlodipine 10 mg-Perindopril 14 mg orally once a day

Comments:
-Wait 7 to 14 days between titration steps.
-May be used as initial therapy if multiple drugs are likely needed to achieve blood pressure goals.

Renal Dose Adjustments

Mild renal dysfunction (CrCl 60 to less than 90 mL/min): Data not available
Moderate to severe renal dysfunction (CrCl less than 60 mL/min): Not recommended

Liver Dose Adjustments

Not recommended

Precautions

US BOXED WARNING:
-FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus.

Safety and efficacy have not been established in patients younger than 18 years; not recommended in patients 65 years or older.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:
-Assess renal function and serum electrolytes prior to initiating therapy and periodically during treatment.
-In patients at risk of excessive hypotension, initiate this drug with caution and monitor closely for the first 2 weeks and whenever the dose of this drug is increased or a diuretic is added or its dose is increased.

Patient advice:
-Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
-In case of a missed dose, resume the usual dose at the next scheduled time.

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