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Medications for Schizophrenia

Other names: Catatonic Schizophrenia; Disorganized Schizophrenia; Paranoid Schizophrenia; Residual Schizophrenia; Schizophrenia, catatonic; Schizophrenia, disorganized; Schizophrenia, paranoid; Schizophrenia, residual; Schizophrenia, undifferentiated; Undifferentiated Schizophrenia

Schizophrenia is a serious brain disorder. It is a disease that makes it difficult for a person to tell the difference between real and unreal experiences, to think logically, to have normal emotional responses to others, and to behave normally in social situations.

Drugs used to treat Schizophrenia

The medications listed below are related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
6.4 47 reviews for Seroquel to treat Schizophrenia Rx C N
Generic name:
quetiapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
September 29, 1997
6.2 113 reviews for Abilify to treat Schizophrenia Rx C N
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
November 6, 2007
5.2 148 reviews for risperidone to treat Schizophrenia Rx C N
Generic name:
risperidone systemic
Brand names:
Risperdal, Risperdal Consta, Perseris, Risvan, Uzedy, Rykindo
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
6.3 130 reviews for Latuda to treat Schizophrenia Rx B N
Generic name:
lurasidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
January 28, 2017
5.5 142 reviews for olanzapine to treat Schizophrenia Rx C N
Generic name:
olanzapine systemic
Brand names:
Zyprexa, Zyprexa Relprevv
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
8.1 62 reviews for clozapine to treat Schizophrenia Rx B N
Generic name:
clozapine systemic
Brand names:
Clozaril, Versacloz
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
6.1 65 reviews for Vraylar to treat Schizophrenia Rx N
Generic name:
cariprazine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
September 17, 2015
5.9 71 reviews for Zyprexa to treat Schizophrenia Rx C N
Generic name:
olanzapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
March 30, 2004
6.9 84 reviews for quetiapine to treat Schizophrenia Rx C N
Generic name:
quetiapine systemic
Brand names:
Seroquel, Seroquel XR
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
6.0 49 reviews for Rexulti to treat Schizophrenia Rx N
Generic name:
brexpiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
July 10, 2015
6.4 39 reviews for Abilify Maintena to treat Schizophrenia Rx C N
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
December 6, 2014
5.4 54 reviews for Risperdal to treat Schizophrenia Rx C N
Generic name:
risperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
December 29, 1993
5.4 47 reviews for Caplyta to treat Schizophrenia Rx N
Generic name:
lumateperone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
April 25, 2022
6.7 18 reviews for Fanapt to treat Schizophrenia Rx C N
Generic name:
iloperidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
May 7, 2009
6.0 186 reviews for aripiprazole to treat Schizophrenia Rx C N
Generic name:
aripiprazole systemic
Brand names:
Abilify, Abilify Maintena, Abilify Asimtufii, Aristada, Abilify MyCite, Aristada Initio, Opipza
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
8.3 3 reviews for Lybalvi to treat Schizophrenia Rx N
Generic name:
olanzapine / samidorphan systemic
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
June 1, 2021
Rate Add review Rx C N
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
April 28, 2023
6.3 54 reviews for brexpiprazole to treat Schizophrenia Rx N
Generic name:
brexpiprazole systemic
Brand name:
Rexulti
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
6.3 77 reviews for cariprazine to treat Schizophrenia Rx N
Generic name:
cariprazine systemic
Brand name:
Vraylar
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
9.0 13 reviews for Clozaril to treat Schizophrenia Rx B N
Generic name:
clozapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
6.6 5 reviews for Cobenfy to treat Schizophrenia Rx N
Generic name:
trospium / xanomeline systemic
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
FDA approval date:
September 27, 2024
5.5 48 reviews for lumateperone to treat Schizophrenia Rx N
Generic name:
lumateperone systemic
Brand name:
Caplyta
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
8.3 4 reviews for olanzapine / samidorphan to treat Schizophrenia Rx N
Generic name:
olanzapine / samidorphan systemic
Brand name:
Lybalvi
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
6.4 47 reviews for Geodon to treat Schizophrenia Rx C N
Generic name:
ziprasidone systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
9.0 12 reviews for chlorpromazine to treat Schizophrenia Rx N N
Generic name:
chlorpromazine systemic
Drug class:
phenothiazine antiemetics, phenothiazine antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information

Frequently asked questions

View more FAQ

Topics under Schizophrenia

Learn more about Schizophrenia

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Available for purchase by prescription only.
OTC Available for purchase over-the-counter.
Rx/OTC Available for purchase by prescription or over-the-counter.
Alcohol The medication interacts with alcohol (if marked with "✕").
New approval The FDA has approved this medication within the past year.
Off-label The FDA may not approve this medication for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded access Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.