Cobenfy Side Effects

Generic name: trospium / xanomeline

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Note: This document provides detailed information about Cobenfy.

Applies to trospium / xanomeline: oral capsules Side Effects associated with trospium / xanomeline. Some dosage forms listed on this page may not apply specifically to the brand name Cobenfy.

Applies to trospium / xanomeline: oral capsules.

Side effects include:

Most common adverse reactions (≥5%): nausea, dyspepsia, constipation, vomiting, hypertension, abdominal pain, diarrhea, tachycardia, dizziness, GI reflux disease.

For healthcare professionals

Applies to trospium/xanomeline: oral capsule.

General adverse events

The most common adverse reactions were nausea, dyspepsia, constipation, vomiting, hypertension, abdominal pain, diarrhea, tachycardia, dizziness, and gastroesophageal reflux disease.^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (11%)
• Common (1% to 10%): Tachycardia/increased heart rate, orthostatic hypotension
• Postmarketing reports: Chest pain, hypertensive crisis, palpitations, supraventricular tachycardia, syncope

Dermatologic

• Postmarketing reports: Rash, angioedema, Stevens-Johnson syndrome

Gastrointestinal

• Very common (10% or more): Nausea (19%), dyspepsia/esophageal discomfort (18%), constipation (17%), vomiting (15%)
• Common (1% to 10%): Abdominal pain, diarrhea, gastroesophageal reflux disease, dry mouth, salivary hypersecretion
• Postmarketing reports: Gastritis

Genitourinary

• Common (1% to 10%): Urinary retention

Hepatic

• Common (1% to 10%): Elevated liver enzymes
• Frequency not reported: Biliary obstruction

Hypersensitivity

• Postmarketing reports: Anaphylactic reaction (including angioedema of the face, lips, tongue, and/or larynx)

Musculoskeletal

• Postmarketing reports: Rhabdomyolysis

Nervous system

• Common (1% to 10%): Dizziness, somnolence, extrapyramidal symptoms (non-akathisia)
• Frequency not reported: Anticholinergic central nervous system effects
• Postmarketing reports: Confusion, delirium, dizziness, hallucinations

Ocular

• Common (1% to 10%): Blurred vision
• Postmarketing reports: Abnormal vision

Respiratory

• Common (1% to 10%): Cough/productive cough

See also:

Further information

Cobenfy side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer