Drug Interactions between ibuprofen and nortriptyline
This report displays the potential drug interactions for the following 2 drugs:
- ibuprofen
- nortriptyline
Interactions between your drugs
No interactions were found between ibuprofen and nortriptyline. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
ibuprofen
A total of 414 drugs are known to interact with ibuprofen.
- Ibuprofen is in the drug class Nonsteroidal anti-inflammatory drugs.
-
Ibuprofen is used to treat the following conditions:
- Aseptic Necrosis
- Back Pain
- Chronic Myofascial Pain
- Chronic Pain
- Costochondritis
- Diffuse Idiopathic Skeletal Hyperostosis
- Dysautonomia
- Eustachian Tube Dysfunction
- Fever
- Frozen Shoulder
- Gout, Acute
- Headache
- Herniated Disk (off-label)
- Juvenile Rheumatoid Arthritis
- Migraine
- Muscle Pain
- Neck Pain
- Osteoarthritis
- Pain
- Pain/Fever
- Patent Ductus Arteriosus
- Period Pain
- Plantar Fasciitis
- Polymyalgia Rheumatica
- Radiculopathy
- Rheumatoid Arthritis
- Sciatica
- Spondylolisthesis
- Temporomandibular Joint Disorder
- Toothache
- Transverse Myelitis
nortriptyline
A total of 701 drugs are known to interact with nortriptyline.
- Nortriptyline is in the drug class tricyclic antidepressants.
-
Nortriptyline is used to treat the following conditions:
- Burning Mouth Syndrome (off-label)
- Chronic Pain
- Cyclic Vomiting Syndrome (off-label)
- Depression
- Diabetic Peripheral Neuropathy (off-label)
- Dysautonomia (off-label)
- Irritable Bowel Syndrome (off-label)
- Migraine Prevention (off-label)
- Neuralgia (off-label)
- Neurosis (off-label)
- Pain (off-label)
- Panic Disorder (off-label)
- Postherpetic Neuralgia (off-label)
- Primary Nocturnal Enuresis (off-label)
- Reflex Sympathetic Dystrophy Syndrome (off-label)
- Smoking Cessation (off-label)
- Tinnitus (off-label)
- Vulvodynia (off-label)
Drug and food interactions
ibuprofen food
Applies to: ibuprofen
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References (1)
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
nortriptyline food
Applies to: nortriptyline
GENERALLY AVOID: Concomitant use of ethanol and a tricyclic antidepressant (TCA) may result altered TCA plasma levels and efficacy, and additive impairment of motor skills, especially driving skills. Acute ethanol ingestion may inhibit TCA metabolism, while chronic ingestion of large amounts of ethanol may induce hepatic TCA metabolism.
MANAGEMENT: Patients should be advised to avoid alcohol during TCA therapy. Alcoholics who have undergone detoxification should be monitored for decreased TCA efficacy. Dosage adjustments may be required.
References (7)
- Dorian P, Sellers EM, Reed KL, et al. (1983) "Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction." Eur J Clin Pharmacol, 25, p. 325-31
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Sandoz M, Vandel S, Vandel B, Bonin B, Allers G, Volmat R (1983) "Biotransformation of amitriptyline in alcoholic depressive patients." Eur J Clin Pharmacol, 24, p. 615-21
- Ciraulo DA, Barnhill JG, Jaffe JH (1988) "Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers." Clin Pharmacol Ther, 43, p. 509-18
- Seppala T, Linnoila M, Elonen E, Mattila MJ, Makl M (1975) "Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving." Clin Pharmacol Ther, 17, p. 515-22
- Ciraulo DA, Barnhill JG, Jaffe JH, Ciraulo AM, Tarmey MF (1990) "Intravenous pharmacokinetics of 2-hydroxyimipramine in alcoholics and normal controls." J Stud Alcohol, 51, p. 366-72
- Ciraulo DA, Alderson LM, Chapron DJ, Jaffe JH, Subbarao B, Kramer PA (1982) "Imipramine disposition in alcoholics." J Clin Psychopharmacol, 2, p. 2-7
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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