Valproic acid Alternatives Compared
| Valproic acid | Vraylar | Lybalvi |
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| Valproic acid | Vraylar (cariprazine) | Lybalvi (olanzapine / samidorphan) |
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Prescription only
Prescribed for Bipolar Disorder, Epilepsy, Seizure Prevention, Seizures, Headache, Cluster-Tic Syndrome, Hyperekplexia, Mania, Migraine, Migraine Prevention, Schizoaffective Disorder. valproic acid... View more |
Prescription only
Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more |
Prescription only
Prescribed for Bipolar Disorder, Schizophrenia. Lybalvi may also be used for purposes not listed in this medication guide. |
Related suggestions Popular comparisons
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| More about Valproic acid | More about Vraylar (cariprazine) | More about Lybalvi (olanzapine / samidorphan) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Valproic acid has an average rating of 6.0 out of 10 from a total of 64 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 36% reported a negative effect. |
Vraylar has an average rating of 5.9 out of 10 from a total of 488 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 35% reported a negative effect. |
Lybalvi has an average rating of 8.5 out of 10 from a total of 12 ratings on Drugs.com. 82% of reviewers reported a positive effect, while 0% reported a negative effect. |
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| Side Effects | ||||||||||||||||||||||||||
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See also: valproic acid side effects in more detail. |
See also: Vraylar side effects in more detail. |
See also: Lybalvi side effects in more detail. |
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| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all valproic acid prices |
View all Vraylar prices |
View all Lybalvi prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Valproate Sodium |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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16 hours |
504 hours |
54 hours (empirically) |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
When Treating Epilepsy
Category X
Not for use in pregnancy
When Treating Migraine See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 408 drugs are known to interact with valproic acid:
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A total of 569 drugs are known to interact with Vraylar:
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A total of 696 drugs are known to interact with Lybalvi:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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February 28, 1978 |
September 17, 2015 |
May 28, 2021 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.