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Soliqua Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Soliqua Metformin Ozempic
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Soliqua (insulin glargine / lixisenatide) Metformin Ozempic (semaglutide)
Prescription only

Soliqua contains insulin glargine and lixisenatide and may be used to treat type 2 diabetes in adults alongside diet and exercise. It only needs to be given once a day but may not be suitable for... View more

Prescription only

Metformin improves how the body responds to insulin and it is effective for the treatment of type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

Related suggestions
More about Soliqua (insulin glargine / lixisenatide) More about Metformin More about Ozempic (semaglutide)
Generic Status

No lower-cost generic available

Lower-cost generic is available

No lower-cost generic available
Ratings & Reviews

Soliqua has an average rating of 4.1 out of 10 from a total of 16 ratings on Drugs.com. 25% of reviewers reported a positive effect, while 44% reported a negative effect.

Metformin has an average rating of 6.9 out of 10 from a total of 645 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 19% reported a negative effect.

Ozempic has an average rating of 6.2 out of 10 from a total of 1123 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 30% reported a negative effect.

View all 16 reviews

View all 645 reviews

View all 1123 reviews

Drug Class
Side Effects

See also: Soliqua side effects in more detail.

See also: metformin side effects in more detail.

See also: Ozempic side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 15 mL
Dosage 100 units-33 mcg/mL
Per Unit* $60.19
Cost* $902.92

View all Soliqua prices

Quantity 100 each
Dosage 500 mg
Per Unit* $0.16 - $0.22
Cost* $16.02 - $22.18

View all metformin prices

Quantity 1.5 mL
Dosage 2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per Unit* $663.24
Cost* $994.86

View all Ozempic prices

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Dosage Form(s) Available
  • Subcutaneous solution
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
  • Subcutaneous solution
Brand Names

N/A

 Glumetza Other semaglutide brands include: Rybelsus, Wegovy
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

24 hours

4.5 hours

168 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category

Summary unavailable.

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 404 drugs are known to interact with Soliqua:

  • 16 major drug interactions (41 brand and generic names)
  • 364 moderate drug interactions (1906 brand and generic names)
  • 24 minor drug interactions (216 brand and generic names)

A total of 363 drugs are known to interact with metformin:

  • 20 major drug interactions (113 brand and generic names)
  • 334 moderate drug interactions (1754 brand and generic names)
  • 9 minor drug interactions (35 brand and generic names)

A total of 249 drugs are known to interact with Ozempic:

  • 2 major drug interactions (5 brand and generic names)
  • 246 moderate drug interactions (1408 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more
  • Lixisenatide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more
  • Semaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
Disease Interactions
First Approval Date

N/A

March 03, 1995

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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