Comparing Silenor vs Trazodone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Silenor (doxepin)	Trazodone	Enter another drug to compare

Silenor (doxepin)

Trazodone

Prescription only

Prescribed for Insomnia. Silenor may also be used for purposes not listed in this medication guide.

Prescription only

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

More about Silenor (doxepin)

More about Trazodone

Ratings & Reviews

Silenor has an average rating of 6.5 out of 10 from a total of 127 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 35% reported a negative effect.

Trazodone has an average rating of 6.3 out of 10 from a total of 1435 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect.

View all 127 reviews

View all 1435 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (8.7%)
Anxiety (6.3%)
Depression (5.5%)
Headaches (3.9%)
Nightmares (3.9%)
Hallucinations (3.1%)
Hangover (3.1%)

View all Silenor side effects

Drowsiness (17.7%)
Headaches (9.5%)
Dizziness (8.6%)
Anxiety (5.9%)
Dry mouth (5.7%)
Tiredness (4.9%)
Insomnia (4.6%)

View all Trazodone side effects

Drug Class

Phenylpiperazine antidepressants

Generic Availability

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet
Strength	3 mg
Per unit^*	$19.51
Cost^*	$585.18

View all Silenor prices

Quantity	100 each
Strength	50 mg
Per unit^*	$0.20 - $0.21
Cost^*	$20.37 - $20.92

View all Trazodone prices

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Dosage Forms

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

25 hours

7.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 704 drugs are known to interact with Silenor:

143 major drug interactions (604 brand and generic names)
537 moderate drug interactions (2166 brand and generic names)
24 minor drug interactions (157 brand and generic names)

A total of 674 drugs are known to interact with Trazodone:

138 major drug interactions (504 brand and generic names)
521 moderate drug interactions (2174 brand and generic names)
15 minor drug interactions (71 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using doxepin together with alcohol, this can alter the effects of doxepin... View more

Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

March 17, 2010

December 24, 1981

WADA Class View classifications

N/A

More Information

Patient Resources

Silenor uses

Trazodone uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Silenor vs Trazodone

See also:

Ativan

Benadryl

Trodelvy

Ambien

Lunesta

Quviviq

Belsomra

Restoril

Dayvigo

Banophen

Further information

Comparing Silenor vs Trazodone

See also:

Further information

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