Comparing Sertraline vs Trintellix

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Sertraline

Trintellix vortioxetine

Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Prescribed for Panic Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder... View more

Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibiting... View more

Prescription only

Ratings & Reviews

View all 3661 reviews

View all 965 reviews

Drug Class

Selective serotonin reuptake inhibitors

Miscellaneous antidepressants

Side Effects

Commonly reported side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia.

See the full sertraline side effects document.

Common side effects include: diarrhea, male sexual disorder, and nausea.

See the full Trintellix side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	100 each
Dosage	100 mg
Per Unit^*	$0.55 - $0.56
Cost^*	$54.65 - $56.06

View all sertraline prices

Quantity	30 tablet
Dosage	5 mg
Per Unit^*	$15.04
Cost^*	$451.10

View all Trintellix prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral concentrate
Oral tablet

Oral tablet

Brand Names

Zercapli, Zoloft

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

66 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 624 drugs are known to interact with sertraline:

143 major drug interactions (564 brand and generic names)
474 moderate drug interactions (1948 brand and generic names)
7 minor drug interactions (35 brand and generic names)

A total of 331 drugs are known to interact with Trintellix:

91 major drug interactions (425 brand and generic names)
239 moderate drug interactions (944 brand and generic names)
1 minor drug interactions (3 brand and generic names)

Alcohol/Food/Lifestyle Interactions

You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can... View more

Alcohol can increase the nervous system side effects of vortioxetine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 30, 1991

September 30, 2013

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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