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Ryclora Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Ryclora (dexchlorpheniramine) Benadryl (diphenhydramine) Diphenhydramine
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Ryclora (dexchlorpheniramine) Benadryl (diphenhydramine) Diphenhydramine
Prescription only

Prescribed for Allergic Rhinitis, Allergic Reactions. Ryclora may also be used for purposes not listed in this medication guide.

Prescription and OTC

Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more

Prescription and OTC

Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more

More about Ryclora (dexchlorpheniramine) More about Benadryl (diphenhydramine) More about Diphenhydramine
Ratings & Reviews

Be the first to share your experience with this drug.

Benadryl has an average rating of 7.2 out of 10 from a total of 78 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 18% reported a negative effect.

Diphenhydramine has an average rating of 5.5 out of 10 from a total of 534 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 40% reported a negative effect.

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View all 78 reviews

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Drug Class
Side Effects

Ryclora side effects

Benadryl side effects

Diphenhydramine side effects
Generic Availability

N/A

N/A

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 118 mL
Strength 2 mg/5 mL
Per Unit* $3.21
Cost* $378.51

View all Ryclora prices

Quantity 24 tablet
Strength 25 mg
Per Unit* $0.42
Cost* $9.99

View all Benadryl prices

Quantity 12 each
Strength 25 mg
Per Unit* $0.95
Cost* $11.42

View all Diphenhydramine prices

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Dosage Forms Available
  • Oral syrup
  • Oral capsule
  • Oral tablet
  • Injectable solution
  • Oral capsule
  • Oral liquid
  • Oral tablet
  • Oral tablet, chewable
Brand Names
Other dexchlorpheniramine brands include: Polmon Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

24 hours

9.3 hours

9.3 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
Drug Interactions

A total of 267 drugs are known to interact with Ryclora:

  • 8 major drug interactions (68 brand and generic names)
  • 257 moderate drug interactions (1192 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)

A total of 451 drugs are known to interact with Benadryl:

  • 14 major drug interactions (90 brand and generic names)
  • 435 moderate drug interactions (1680 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)

A total of 451 drugs are known to interact with Diphenhydramine:

  • 14 major drug interactions (90 brand and generic names)
  • 435 moderate drug interactions (1680 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of dexchlorpheniramine such as dizziness... View more
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
Disease Interactions
First Approval Date

N/A

March 04, 1946

March 04, 1946
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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