Risperdal Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Risperdal (risperidone)	Vraylar (cariprazine)	Caplyta (lumateperone)	Enter another drug to compare

Risperdal (risperidone)

Vraylar (cariprazine)

Caplyta (lumateperone)

Prescription only

Risperdal is an antipsychotic that relieves psychotic symptoms in people with schizophrenia or mania and is also used in the treatment of autistic disorder. Side effects are less likely at lower... View more

Prescription only

Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar I disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

More about Risperdal (risperidone)

More about Vraylar (cariprazine)

More about Caplyta (lumateperone)

Ratings & Reviews

Risperdal has an average rating of 6.0 out of 10 from a total of 241 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 29% reported a negative effect.

Vraylar has an average rating of 6.1 out of 10 from a total of 524 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 32% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 185 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 29% reported a negative effect.

View all 241 reviews

View all 524 reviews

View all 185 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Weight gain (30.7%)
Hallucinations (7.9%)
Drowsiness (7.5%)
Depression (6.6%)
Tiredness (6.2%)
Anxiety (5.4%)
Increased appetite (5.0%)

View all Risperdal side effects

Restlessness (16.4%)
Insomnia (14.5%)
Weight gain (12.2%)
Nausea (9.9%)
Anxiety (9.0%)
Tiredness (5.7%)
Hallucinations (5.5%)

View all Vraylar side effects

Headaches (14.1%)
Dry mouth (10.3%)
Nausea (10.3%)
Dizziness (9.7%)
Drowsiness (9.7%)
Tiredness (9.2%)
Weight gain (6.5%)

View all Caplyta side effects

Drug Class

Atypical antipsychotics

Atypical antipsychotics

Atypical antipsychotics

Generic Availability

Lower cost generic approved

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	60 tablet
Strength	0.5 mg
Per unit^*	$5.09
Cost^*	$305.24

View all Risperdal prices

Quantity	20 each
Strength	1.5 mg
Per unit^*	$54.55
Cost^*	$1,090.96

View all Vraylar prices

Quantity	30 each
Strength	42 mg
Per unit^*	$61.18
Cost^*	$1,835.40

View all Caplyta prices

Get free Discount Card

Dosage Forms

Oral solution
Oral tablet

Oral capsule

Oral capsule

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

24 hours

504 hours

18 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 680 drugs are known to interact with Risperdal:

125 major drug interactions (443 brand and generic names)
549 moderate drug interactions (2223 brand and generic names)
6 minor drug interactions (30 brand and generic names)

A total of 577 drugs are known to interact with Vraylar:

94 major drug interactions (385 brand and generic names)
481 moderate drug interactions (1833 brand and generic names)
2 minor drug interactions (5 brand and generic names)

A total of 605 drugs are known to interact with Caplyta:

167 major drug interactions (620 brand and generic names)
436 moderate drug interactions (1722 brand and generic names)
2 minor drug interactions (5 brand and generic names)

Alcohol/Food/Lifestyle Interactions

RisperiDONE oral solution should not be mixed with tea or cola. It may be taken with water... View more

Grapefruit juice can increase the blood levels of cariprazine. This may increase side effects such... View more
Using cariprazine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 29, 1993

September 17, 2015

December 20, 2019

WADA Class View classifications

N/A

More Information

Patient Resources

Risperdal uses

Vraylar uses

Caplyta uses

Professional Resources

Prescribing information

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Risperdal Alternatives Compared

See also:

Rexulti

Vraylar

Caplyta

Abilify

Seroquel

Prozac

Lamictal

Depakote

Zyprexa

Latuda

Further information

Risperdal Alternatives Compared

See also:

Further information

Compare Drugs