Generic name: risperidone (injection) [ ris-PER-i-done ]
Other brand names of risperidone (injection) include Perseris, RisperDAL Consta, Uzedy
Drug class: Atypical antipsychotics

Medically reviewed by Drugs.com on Jun 28, 2023. Written by Cerner Multum.

What is Perseris?

Perseris injection is used in adults to treat schizophrenia.

Risperdal Consta is used in adults alone or in combination with lithium or valproate for the treatment of bipolar disorder.

Perseris may also be used for purposes not listed in this medication guide.

Perseris side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

High doses or long-term use of risperidone can cause a serious movement disorder that may not be reversible. The longer you use Perseris, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Perseris may cause serious side effects. Call your doctor at once if you have:

• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

• breast swelling and tenderness, nipple discharge, loss of interest in sex, impotence, erectile dysfunction, difficulty having an orgasm, missed menstrual periods;

• feeling unusually hot or cold;

• low blood pressure, fast or pounding heartbeats, fluttering in your chest;

• shortness of breath, sudden dizziness (like you might pass out);

• seizure;

• trouble swallowing;

• signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding;

• severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

• high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;

• low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or

• a painful or prolonged erection.

Common side effects of Perseris may include:

• headache;

• blurred vision, rash;

• dizziness, drowsiness, tired feeling;

• tremors, twitching or uncontrollable muscle movements, numbness;

• depressed mood, agitation, anxiety, feeling restless;

• back pain, muscle or joint pain, pain in your arms or legs;

• upset stomach, constipation, dry mouth;

• upper stomach pain, nausea, vomiting, diarrhea;

• increased salivation;

• cold symptoms such as stuffy nose, sneezing, sore throat;

• increased appetite, weight gain; or

• itching, bruising, swelling, irritation, warmth, redness, and a hard lump (induration) where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Perseris is not approved for use in older adults with dementia-related psychosis.

Before taking this medicine

You should not use this medication if you are allergic to Perseris or paliperidone.

Perseris may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have or have ever had:

• heart disease or a heart attack;

• dizziness, rapid heartbeats, fainting;

• a stroke, a TIA or "mini-stroke";

• Parkinson's disease or a type of dementia called Lewy body dementia;

• trouble swallowing;

• low white blood cell (WBC) counts;

• a severe nervous system reaction while using medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;

• diabetes (in you or a family member);

• high cholesterol or triglycerides;

• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

• a seizure;

• low bone mineral density;

• breast cancer;

• dehydration; or

• liver or kidney disease.

Using antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of risperidone on the baby.

It may be harder for you to get pregnant while you are using Perseris.

If you are breastfeeding, tell your doctor if you notice drowsiness, irregular growth, tremors and abnormal muscle movements in the nursing baby.

How is Perseris given?

If you already use other antipsychotic medication, you may need to keep using it for a short time. Do not change your dose or dosing schedule without your doctor's advice.

You may need to take Perseris by mouth (in pill or liquid form) before you start receiving this medicines. Follow your doctor's dosing instructions very carefully.

Perseris is injected under the skin or into a muscle.

A healthcare provider will give you this injection.

Risperdal Consta is usually given once every 2 weeks. Perseris is usually given once every month. Uzedy is usually given once every month or once every 2 months.

Your blood may need to be tested often.

Your doctor will need to check your progress on a regular basis and you may need other medical tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Perseris.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Perseris?

Do not drink alcohol. Dangerous side effects could occur.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid driving or hazardous activity until you know how Perseris will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

What other drugs will affect Perseris?

Using Perseris with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your current medicines. Many drugs can affect Perseris, especially:

• methylphenidate;

• clozapine; or

• blood pressure medications.

This list is not complete and many other drugs may affect Perseris. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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