Generic name: risperidone (injection) [ ris-PER-i-done ]
Brand names: Perseris, RisperDAL Consta

Medically reviewed by Drugs.com on Jan 26, 2023. Written by Cerner Multum.

What is Perseris?

Perseris is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Perseris is used to treat schizophrenia and symptoms of bipolar disorder (manic depression).

Perseris is sometimes given with lithium or valproate (Depakene).

Perseris may also be used for purposes not listed in this medication guide.

Warnings

Perseris is not approved for use in older adults with dementia-related psychosis.

Before taking this medicine

You should not be treated with Perseris if you are allergic to Perseris or paliperidone.

Perseris may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

• heart disease, high blood pressure, or a heart attack;

• Parkinson's disease;

• trouble swallowing;

• low white blood cell (WBC) counts;

• diabetes (or risk factors such as obesity or family history of diabetes);

• liver or kidney disease;

• a seizure;

• low bone mineral density;

• breast cancer; or

• if you are dehydrated.

Some people with mental illness have thoughts about suicide. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Using antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, fussiness, tremors, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop using Perseris without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of risperidone on the baby.

Tell your doctor if you are breast-feeding. Risperidone can pass into breast milk and may cause drowsiness, fussiness, abnormal muscle movements, or feeding problems in a nursing baby.

How is Perseris given?

If you already use other antipsychotic medication, you may need to keep using it for a short time. Do not change your dose or dosing schedule without your doctor's advice.

You may need to take Perseris by mouth (in pill or liquid form) before you start receiving this medicines. Follow your doctor's dosing instructions very carefully.

Perseris is injected under the skin or into a muscle.

A healthcare provider will give you this injection.

Risperdal Consta is usually given once every 2 weeks. Perseris is usually given once every month.

If you use Perseriss long-term, your doctor will need to check your progress on a regular basis.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving Perseris?

Avoid drinking alcohol. Dangerous side effects could occur.

While you are receiving Perseris, you may be more sensitive to very hot conditions. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise.

Avoid driving or hazardous activity until you know how Perseris will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Perseris side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Perseris may cause serious side effects. Call your doctor at once if you have:

• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

• breast swelling or tenderness (in men or women), nipple discharge, impotence, lack of interest in sex, missed menstrual periods;

• severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

• high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;

• low blood cell counts--fever, mouth sores, skin sores, sore throat, cough, easy bruising, unusual bleeding, trouble breathing, feeling light-headed; or

• penis erection that is painful or lasts 4 hours or longer.

Serious side effects may be more likely in older adults.

Common side effects of Perseris may include:

• headache;

• dizziness, drowsiness, tired feeling;

• tremors, twitching or uncontrollable muscle movements;

• depressed mood, agitation, anxiety, restless feeling;

• muscle or joint pain;

• dry mouth, upset stomach, constipation;

• weight gain; or

• pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Perseris?

Using Perseris with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect Perseris, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

• What is the difference between Perseris and Risperdal Consta?

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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