Comparing Prolia vs Zoledronic Acid
Prolia | Zoledronic acid |
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Prolia (denosumab) | Zoledronic acid |
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Prescription only
Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation and... View more |
Prescription only
Zoledronic acid is only available as an injection for administration by a healthcare provider. It must be administered over no less than 15 minutes but only needs to be given once a year when used... View more |
Related suggestions |
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More about Prolia (denosumab) | More about Zoledronic acid | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Prolia has an average rating of 2.7 out of 10 from a total of 362 ratings on Drugs.com. 15% of reviewers reported a positive effect, while 78% reported a negative effect. |
Zoledronic acid has an average rating of 4.8 out of 10 from a total of 393 ratings on Drugs.com. 34% of reviewers reported a positive effect, while 48% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: Prolia side effects in more detail. |
See also: zoledronic acid side effects in more detail. |
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Generic Availability | |||||||||||||||||
N/A |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Prolia prices |
View all zoledronic acid prices |
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Dosage Form(s) Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Other denosumab brands include: Jubbonti, Wyost, Xgeva | Aclasta, Reclast, Zometa | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
609.6 hours |
N/A |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 284 drugs are known to interact with Prolia:
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A total of 122 drugs are known to interact with zoledronic acid:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
June 01, 2010 |
December 28, 2015 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.