Comparing Prolia vs Zoledronic Acid
| Prolia (denosumab) | Zoledronic acid |
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| Prolia (denosumab) | Zoledronic acid |
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Prescription only
Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation and... View more |
Prescription only
Zoledronic acid strengthens bones and is used to manage several different bone-related conditions. Zoledronic acid injection (Reclast, 5 mg/100 mL) is used to treat and prevent postmenopausal or... View more |
Related suggestions Osteoporosis
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| More about Prolia (denosumab) | More about Zoledronic acid | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Prolia has an average rating of 2.9 out of 10 from a total of 374 ratings on Drugs.com. 16% of reviewers reported a positive effect, while 76% reported a negative effect. |
Zoledronic acid has an average rating of 5.0 out of 10 from a total of 413 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 46% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Prolia side effects |
View all Zoledronic acid side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Prolia prices |
View all Zoledronic acid prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other denosumab brands include: Bomyntra, Conexxence, Jubbonti, Osenvelt, Ospomyv, Stoboclo, Wyost, Xbryk, Xgeva View more | Aclasta, Reclast, Zometa | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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609.6 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 307 drugs are known to interact with Prolia:
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A total of 123 drugs are known to interact with Zoledronic acid:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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June 01, 2010 |
December 28, 2015 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Fosamax
Fosamax (alendronate) is used to treat or prevent postmenopausal osteoporosis and steroid-induced ...
Premarin
Premarin is used to treat symptoms of menopause such as hot flashes, and vaginal dryness. Learn ...
Evenity
Evenity (romosozumab) injection is used to treat osteoporosis in postmenopausal women to reduce the ...
Reclast
Reclast (zoledronic acid) is used to treat osteoporosis in women after menopause and also to treat ...
Zometa
Zometa is used to treat high blood levels of calcium caused by cancer and multiple myeloma. Learn ...
Xgeva
Xgeva prevents bone fractures and other skeletal conditions in people with multiple myeloma, and is ...
Atelvia
Atelvia (risedronate) is used to treat osteoporosis in women after menopause. Includes Atelvia side ...
Boniva
Boniva (ibandronate) is used to treat or prevent osteoporosis in women after menopause. Includes ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.