Prolia (denosumab) Disease Interactions
There are 2 disease interactions with Prolia (denosumab):
Denosumab (Includes Prolia) ↔ Hypocalcemia
Severe Potential Hazard, Moderate plausibility
Applies to: Hypocalcemia, Hypoparathyroidism, Hypothyroidism, Thyroid Disease, Renal Dysfunction, hemodialysis
Preexisting hypocalcemia must be corrected prior to initiating treatment with denosumab. Caution should be exercised in patients predisposed to hypocalcemia and any disturbances of mineral metabolism, such as history of hypoparathyroidism, thyroid or parathyroid surgery, malabsorption syndromes, excision of small intestine, severe renal impairment or dialysis. Clinical monitoring of calcium and mineral levels (phosphorus and magnesium) are highly recommended within 14 days of denosumab injection. It is important to maintain calcium levels with adequate calcium and vitamin D supplementation.
Denosumab (Includes Prolia) ↔ Immunosuppression
Moderate Potential Hazard, Moderate plausibility
Applies to: Immunodeficiency
Denosumab should be used with caution in patients with impaired immune systems or taking concomitant immunosuppressant agents as they may be at increased risk for serious infections.
Prolia (denosumab) drug Interactions
There are 198 drug interactions with Prolia (denosumab)
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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