Comparing Fosamax vs Prolia
| Fosamax | Prolia |
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| Fosamax (alendronate) | Prolia (denosumab) |
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Prescription only
Fosamax helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. Dosage instructions, including remaining upright for at least 30 minutes and taking with a... View more |
Prescription only
Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation and... View more |
Related suggestions Popular comparisons
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| More about Fosamax (alendronate) | More about Prolia (denosumab) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Fosamax has an average rating of 2.6 out of 10 from a total of 74 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 81% reported a negative effect. |
Prolia has an average rating of 2.8 out of 10 from a total of 365 ratings on Drugs.com. 15% of reviewers reported a positive effect, while 78% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: Fosamax side effects in more detail. |
See also: Prolia side effects in more detail. |
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| Generic Availability | |||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Fosamax prices |
View all Prolia prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other alendronate brands include: Binosto | Other denosumab brands include: Jubbonti, Wyost, Xgeva | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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N/A |
609.6 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 116 drugs are known to interact with Fosamax:
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A total of 288 drugs are known to interact with Prolia:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 29, 1995 |
June 01, 2010 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.