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Binosto

Generic Name: alendronate (a LEN dro nate)
Brand Names: Binosto, Fosamax

What is Binosto?

Binosto (alendronate) is a bisphosphonate (bis FOS fo nayt) medicine that slows bone loss while increasing bone mass, which may prevent bone fractures.

Binosto is used in women to treat osteoporosis caused by menopause.

Binosto is also used to increase bone mass in men who have osteoporosis

Important information

You should not take Binosto if you have problems with your esophagus, or low levels of calcium in your blood.

Do not take Binosto if you cannot sit upright or stand for at least 30 minutes after taking the medicine.

Binosto can cause serious problems in the stomach or esophagus. Stop using this medicine and call your doctor at once if you have chest pain, new or worsening heartburn, or pain when swallowing.

Also call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, or severe pain in your joints, bones, or muscles.

Before taking this medicine

You should not take Binosto if you are allergic to alendronate, or if you have:

  • low levels of calcium in your blood (hypocalcemia); or

  • problems with the muscles in your esophagus (the tube that connects your mouth and stomach).

Do not take Binosto if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus. You must stay upright for at least 30 minutes after taking this medicine.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • trouble swallowing;

  • problems with your stomach or digestion;

  • hypocalcemia;

  • a dental problem (you may need a dental exam before you begin taking Binosto);

  • kidney disease; or

  • any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

The effervescent tablet contains a lot of sodium. Tell your doctor if you are on a low-salt diet before using this form of alendronate.

In rare cases, Binosto may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use alendronate, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether alendronate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Binosto?

Take Binosto exactly as prescribed by your doctor. Alendronate is taken either once daily or once per week. Follow all directions on your prescription label. Do not take alendronate in larger or smaller amounts or for longer than recommended.

Do not swallow, chew, or suck on a Binosto effervescent tablet. This medicine only works if you take it on an empty stomach.

Take Binosto first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. Take this medicine on the same day each week and always first thing in the morning.

You must dissolve your Binosto effervescent tablet in plain water at room temperature before you take it.

To prepare your medicine:

  • Place the Binosto tablet in about a half glass (4 ounces) of plain water. The water should not be cold or hot, and should be at room temperature.

  • Wait at least 5 minutes after the bubbling (effervescence) stops for the tablet to completely dissolve in the water.

  • Stir the liquid medicine for about 10 seconds.

  • Drink all of the liquid medicine in the glass.

  • Add a little more water to the glass, swirl gently and drink right away.

For at least 30 minutes after taking Binosto:

  • Do not lie down or recline.

  • Do not take any other medicine including vitamins, calcium, or antacids.

Pay special attention to your dental hygiene while taking Binosto. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using this medicine.

Binosto is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat. Keep unused effervescent tablets in the foil blister pack.

Your doctor will determine how long to treat you with this medicine. Alendronate is often given for only 3 to 5 years.

Binosto dosing information

Usual Adult Dose of Binosto for Osteoporosis:

Treatment of Osteoporosis in Postmenopausal Women; To Increase Bone Mass in Men with Osteoporosis:
-70 mg orally once a week

Uses:
-Treatment to increase bone mass and reduce the incidence of fractures including hip and spine (vertebral compression fractures) in postmenopausal women with osteoporosis
-Treatment to increase bone mass in men with osteoporosis

Dosage Information (comprehensive)

What happens if I miss a dose?

If you forget to take Binosto on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly schedule on your chosen dose day. Do not take 2 doses in one day.

What happens if I overdose?

Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.

What should I avoid while taking Binosto?

Avoid taking any other medicines for at least 30 minutes after taking Binosto. This includes vitamins, calcium, and antacids. Some medicines can make it harder for your body to absorb alendronate.

Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely.

Avoid drinking large amounts of alcohol. Heavy drinking can also cause bone loss.

Binosto side effects

Get emergency medical help if you have signs of an allergic reaction to Binosto: hives; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Binosto and call your doctor at once if you have:

  • chest pain, new or worsening heartburn;

  • difficulty or pain when swallowing;

  • pain or burning under the ribs or in the back;

  • severe heartburn, burning pain in your upper stomach, or coughing up blood;

  • new or unusual pain in your thigh or hip;

  • jaw pain, numbness, or swelling;

  • severe joint, bone, or muscle pain; or

  • low calcium levels - muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).

Common Binosto side effects may include:

  • heartburn, upset stomach;

  • stomach pain, nausea;

  • diarrhea, constipation; or

  • bone pain, muscle or joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side Effects (complete list)

What other drugs will affect Binosto?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • aspirin; or

  • NSAIDs (nonsteroidal anti-inflammatory drugs) - ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with alendronate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Talk with your doctor about the best dosing schedule for your other medicines.

Where can I get more information?

  • Your pharmacist can provide more information about Binosto.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Binosto only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 12.01.

Date modified: November 08, 2017
Last reviewed: October 11, 2017

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