Premarin Vaginal Alternatives Compared
| Premarin Vaginal | Estradiol | Premarin |
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| Premarin Vaginal conjugated estrogens | Estradiol | Premarin conjugated estrogens |
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Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Postmenopausal Symptoms. Premarin Vaginal may also be used for purposes not listed in this medication guide. |
Estradiol is a synthetic form of estrogen that may be given for several different indications, including the relief of menopausal symptoms or low estrogen levels caused by other conditions. Its use... View more |
Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Abnormal Uterine Bleeding, Breast Cancer - Palliative, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian... View more |
Choose a suggestion below Postmenopausal Symptoms
Atrophic Vaginitis
Atrophic Urethritis
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| More about Premarin Vaginal (conjugated estrogens) | More about Estradiol | More about Premarin (conjugated estrogens) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
No lower-cost generic available |
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| Availability | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Premarin Vaginal has an average rating of 6.7 out of 10 from a total of 16 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 25% reported a negative effect. |
Estradiol has an average rating of 5.8 out of 10 from a total of 469 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 38% reported a negative effect. |
Premarin has an average rating of 7.5 out of 10 from a total of 74 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See the full Premarin Vaginal side effects document. |
Commonly reported side effects include: cerebrovascular accident, infection, malignant neoplasm of breast, endometrium disease, headache, mastalgia. See the full estradiol side effects document. |
See the full Premarin side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Premarin Vaginal prices |
View all estradiol prices |
View all Premarin prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
Alora, Climara, Delestrogen, Depo-Estradiol, Divigel, Dotti, Elestrin, Estra Pellets, Estrace, Estraderm, Estradiol Patch, Estrogel, Evamist, Femring, Lyllana, Menostar, Minivelle, Vivelle-Dot View more | Other conjugated estrogens brands include: Premarin Intravenous | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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8 hours |
16 hours |
N/A |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 135 drugs are known to interact with Premarin Vaginal:
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A total of 308 drugs are known to interact with estradiol:
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A total of 211 drugs are known to interact with Premarin:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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N/A |
July 23, 1975 |
May 08, 1942 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.