Pioglitazone Alternatives Compared
| Pioglitazone | Rybelsus | Mounjaro |
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| Pioglitazone | Rybelsus (semaglutide) | Mounjaro (tirzepatide) |
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Prescription only
Prescribed for Diabetes - Type 2, Nonalcoholic Steatohepatitis. pioglitazone may also be used for purposes not listed in this medication guide. |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Prescribed for Weight Loss (Obesity/Overweight), Diabetes - Type 2. Mounjaro may also be used for purposes not listed in this medication guide. |
Related suggestions Diabetes, Type 2
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| More about Pioglitazone | More about Rybelsus (semaglutide) | More about Mounjaro (tirzepatide) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Pioglitazone has an average rating of 4.5 out of 10 from a total of 53 ratings on Drugs.com. 24% of reviewers reported a positive effect, while 51% reported a negative effect. |
Rybelsus has an average rating of 6.3 out of 10 from a total of 252 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 26% reported a negative effect. |
Mounjaro has an average rating of 8.6 out of 10 from a total of 1008 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 7% reported a negative effect. |
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| Side Effects | ||||||||||||||||||||||||||
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See also: pioglitazone side effects in more detail. |
See also: Rybelsus side effects in more detail. |
See also: Mounjaro side effects in more detail. |
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| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all pioglitazone prices |
View all Rybelsus prices |
View all Mounjaro prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Actos | Other semaglutide brands include: Ozempic, Wegovy | Other tirzepatide brands include: Zepbound | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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24 hours |
168 hours |
120 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 337 drugs are known to interact with pioglitazone:
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A total of 264 drugs are known to interact with Rybelsus:
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A total of 410 drugs are known to interact with Mounjaro:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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July 15, 1999 |
September 20, 2019 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.