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Other names: glitazones

What are Thiazolidinediones?

Thiazolidinediones (also called glitazones) are a class of medicines that may be used for the treatment of type 2 diabetes. They are a type of oral hypoglycemic (a medicine that lowers blood glucose levels).

Thiazolidinediones bind to a receptor called the peroxisome proliferator activated receptor-gamma in adipocytes (fat cells) and promote maturation of fat cells and deposition of fat into peripheral tissues. By reducing circulating fat concentrations, thiazolidinediones improve a person with type 2 diabetes' sensitivity to insulin.

Thiazolidinediones may be used as monotherapy or in combination with other oral agents for type 2 diabetes, such as metformin or sulphonylureas. Weight gain and an increase in peripheral fat mass is a side effect of thiazolidinediones.

List of Thiazolidinediones

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Actos (Pro)
Generic name: pioglitazone
40 reviews
Avandia (Pro)
Generic name: rosiglitazone
8 reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions associated with thiazolidinediones:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.