Pentobarbital Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Pentobarbital	Trazodone	Zolpidem	Enter another drug to compare

Pentobarbital

Trazodone

Zolpidem

Prescription only

Prescribed for Sedation, Insomnia, Status Epilepticus. Pentobarbital may also be used for purposes not listed in this medication guide.

Prescription only

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

Prescription only

Zolpidem induces sleep; however, longer-acting formulations may impair physical and mental capabilities the next day. May induce complex or dangerous sleep-related behaviors like "sleep-driving"... View more

More about Pentobarbital

More about Trazodone

More about Zolpidem

Ratings & Reviews

Pentobarbital has an average rating of 7.0 out of 10 from a total of 4 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 0% reported a negative effect.

Trazodone has an average rating of 6.3 out of 10 from a total of 1432 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect.

Zolpidem has an average rating of 6.9 out of 10 from a total of 1056 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 22% reported a negative effect.

View all 4 reviews

View all 1432 reviews

View all 1056 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Pentobarbital side effects

Drowsiness (17.7%)
Headaches (9.6%)
Dizziness (8.7%)
Anxiety (5.9%)
Dry mouth (5.7%)
Tiredness (4.8%)
Insomnia (4.6%)

View all Trazodone side effects

Memory loss (7.1%)
Drowsiness (6.0%)
Sleepwalking (4.1%)
Depression (3.2%)
Hallucinations (3.2%)
Insomnia (2.7%)
Headaches (2.6%)

View all Zolpidem side effects

Drug Class

Barbiturates

Phenylpiperazine antidepressants

Miscellaneous anxiolytics, sedatives and hypnotics

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	20 mL
Strength	50 mg/mL
Per unit^*	$51.29 - $59.26
Cost^*	$1,025.86 - $1,185.25

View all Pentobarbital prices

Quantity	100 each
Strength	50 mg
Per unit^*	$0.20 - $0.20
Cost^*	$19.62 - $20.17

View all Trazodone prices

Quantity	6 tablet
Strength	10 mg
Per unit^*	$2.96
Cost^*	$17.78

View all Zolpidem prices

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Dosage Forms

Injectable solution

Oral tablet

Oral capsule
Oral tablet
Oral tablet, extended release
Sublingual tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

50 hours

7.5 hours

2.6 hours

CSA Schedule ¹ View glossary of CSA terms

Multiple

The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 551 drugs are known to interact with Pentobarbital:

37 major drug interactions (175 brand and generic names)
487 moderate drug interactions (2443 brand and generic names)
27 minor drug interactions (95 brand and generic names)

A total of 672 drugs are known to interact with Trazodone:

138 major drug interactions (502 brand and generic names)
519 moderate drug interactions (2167 brand and generic names)
15 minor drug interactions (71 brand and generic names)

A total of 480 drugs are known to interact with Zolpidem:

29 major drug interactions (154 brand and generic names)
447 moderate drug interactions (1674 brand and generic names)
4 minor drug interactions (8 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using PENTobarbital together with alcohol, this can add to dizziness... View more

Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more

You should avoid the use of alcohol while being treated with zolpidem. Alcohol can increase the... View more

Disease Interactions

First Approval Date

N/A

December 24, 1981

December 16, 1992

WADA Class View classifications

N/A

More Information

Patient Resources

Pentobarbital uses

Trazodone uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Pentobarbital Alternatives Compared

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