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Pentobarbital Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 3, 2020.

For the Consumer

Applies to pentobarbital: parenteral solution for injection

Side effects include:

Residual sedation, drowsiness, lethargy, vertigo, nausea, vomiting, headache.

For Healthcare Professionals

Applies to pentobarbital: compounding powder, injectable solution, oral capsule, oral elixir, rectal suppository

Nervous system

Common (1% to 10%): Somnolence

Uncommon (0.1% to 1%): Ataxia, central nervous system (CNS) depression, dizziness, hyperkinesia, syncope

Frequency not reported: Headache[Ref]

Psychiatric

Uncommon (0.1% to 1%): Abnormal thinking, agitation, anxiety, confusion, dizziness, hallucination, nervousness, nightmares, psychiatric disturbance[Ref]

Gastrointestinal

Uncommon (0.1% to 1%): Constipation, nausea, vomiting[Ref]

Respiratory

Uncommon (0.1% to 1%): Apnea, hypoventilation[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Bradycardia, hypotension[Ref]

Hypersensitivity

Frequency not reported: Angioedema, hypersensitivity reactions[Ref]

Dermatologic

Frequency not reported: Exfoliative dermatitis, skin rashes[Ref]

Hematologic

Megaloblastic anemia occurred with chronic phenobarbital use.[Ref]

Frequency not reported: Megaloblastic anemia[Ref]

Hepatic

Frequency not reported: Liver damage[Ref]

Other

Frequency not reported: Fever[Ref]

Local

Frequency not reported: Injection site reactions[Ref]

References

1. "Product Information. Pentobarbital (pentobarbital)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

2. "Product Information. Nembutal Sodium (pentobarbital)" Abbott Pharmaceutical, Abbott Park, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.