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Nayzilam Nasal Spray

Generic Name: midazolam (nasal) (my DAZ oh lam)
Brand Names: Nayzilam

Medically reviewed by Judith Stewart, BPharm. Last updated on Nov 12, 2020.

What is Nayzilam?

Nayzilam (midazolam) is a benzodiazepine.

Nayzilam nasal spray is a prescription medicine used short term to treat seizure clusters (also called "acute repetitive seizures") in adults and children at least 12 years old.

Nayzilam is a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep in a safe place to prevent misuse and abuse. Selling or giving away this medicine may harm others and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription drugs, or street drugs.

It is not known if Nayzilam is safe and effective in children under 12 years of age.

Important Information

You should not use Nayzilam if you have narrow-angle glaucoma.

Nayzilam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, if you are hard to wake up, or if you stop breathing.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Some people have thoughts about suicide while using Nayzilam. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Before taking this medicine

You should not use Nayzilam if you are allergic to midazolam, or if you have:

  • narrow-angle glaucoma.

To make sure Nayzilam is safe for you, tell your doctor if you have ever had:

Tell your doctor if you become pregnant. Using Nayzilam during late pregnancy may cause breathing problems, feeding problems, or dangerously low body temperature in the baby.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of midazolam on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I use Nayzilam?

Use Nayzilam exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Midazolam may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Do not take by mouth. This medicine is for use only in the nose.

Before using Nayzilam, be sure you know how to recognize what is and is not a seizure cluster and when it is best to use this medicine. Ask your doctor or pharmacist if you have questions.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Nayzilam is usually given as a single spray into one nostril. If you still have seizures 10 minutes after using 1 spray, use a second spray in the opposite nostril.

Get emergency medical help if you have still have seizures after using this medicine.

You should not use a second spray if you have very slow breathing after using the first spray.

Do not use more than 2 sprays of Nayzilam to treat a seizure cluster. Do not use this medicine to treat more than 1 seizure cluster every 3 days, or more than 5 seizure clusters in one month (30 days).

Store at room temperature away from moisture and heat. Keep the spray bottle in the blister pack until you are ready to use the medicine.

What happens if I miss a dose?

Since Nayzilam is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of midazolam can be fatal.

Overdose symptoms may include severe drowsiness, confusion, muscle weakness, loss of coordination, or coma.

What should I avoid while using Nayzilam?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or doing anything that requires you to be awake and alert until the effects of this medicine have worn off completely. Nayzilam can cause amnesia or forgetfulness that may last for several hours after you have used the medicine.

Nayzilam side effects

Get emergency medical help if you have signs of an allergic reaction to Nayzilam: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Midazolam nasal can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, if you are hard to wake up, or if you stop breathing.

Call your doctor right away or seek emergency medical help if you have:

  • extreme drowsiness;

  • a weak pulse;

  • mood or behavior changes, depression;

  • agitation, anxiety, panic, trouble sleeping, feeling irritable; or

  • thoughts about suicide or hurting yourself.

Common Nayzilam side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nayzilam?

Using Nayzilam with other drugs that slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with midazolam. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Nayzilam only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.