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Novolog Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Novolog Mounjaro Metformin
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Novolog (insulin aspart) Mounjaro (tirzepatide) Metformin
Prescription only

Prescribed for Diabetes - Type 2, Diabetes - Type 1, Diabetic Ketoacidosis, Nonketotic Hyperosmolar Syndrome. Novolog may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Diabetes - Type 2. Mounjaro may also be used for purposes not listed in this medication guide.

Prescription only

Metformin improves how the body responds to insulin and it is effective for the treatment of type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side... View more

More about Novolog (insulin aspart) More about Mounjaro (tirzepatide) More about Metformin
Generic Status

Lower-cost generic is available

No lower-cost generic available

Lower-cost generic is available
Ratings & Reviews

Novolog has an average rating of 5.3 out of 10 from a total of 26 ratings on Drugs.com. 31% of reviewers reported a positive effect, while 42% reported a negative effect.

Mounjaro has an average rating of 6.5 out of 10 from a total of 111 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 29% reported a negative effect.

Metformin has an average rating of 6.9 out of 10 from a total of 626 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 26 reviews

View all 111 reviews

View all 626 reviews

Drug Class
Side Effects

Common side effects include:

  • hypoglycemia

See also: Novolog side effects in more detail.

See also: Mounjaro side effects in more detail.

Commonly reported side effects include:

  • lactic acidosis
  • diarrhea
  • nausea
  • nausea and vomiting
  • vomiting
  • flatulence

See also: metformin side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 10 mL
Dosage 100 units/mL
Per Unit* $31.42
Cost* $314.19

View all Novolog prices and generic prices

Quantity 2 mL
Dosage 2.5 mg/0.5 mL
Per Unit* $543.38
Cost* $1,086.76

View all Mounjaro prices

Quantity 100 each
Dosage 500 mg
Per Unit* $0.16 - $0.22
Cost* $16.02 - $22.18

View all metformin prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Injectable solution
  • Subcutaneous solution
  • Subcutaneous solution
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
Brand Names
Other insulin aspart brands include: Fiasp, NovoLog FlexPen, NovoLog PenFill, ReliOn NovoLog

N/A

 Glumetza, Riomet, Riomet ER
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

1.5 hours

120 hours

4.5 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
Drug Interactions

A total of 377 drugs are known to interact with Novolog:

  • 15 major drug interactions (39 brand and generic names)
  • 321 moderate drug interactions (1563 brand and generic names)
  • 41 minor drug interactions (461 brand and generic names)

A total of 247 drugs are known to interact with Mounjaro:

  • 2 major drug interactions (5 brand and generic names)
  • 224 moderate drug interactions (1144 brand and generic names)
  • 21 minor drug interactions (263 brand and generic names)

A total of 356 drugs are known to interact with metformin:

  • 19 major drug interactions (111 brand and generic names)
  • 308 moderate drug interactions (1478 brand and generic names)
  • 29 minor drug interactions (287 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more
  • Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more
  • MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more
Disease Interactions
First Approval Date

June 07, 2000

N/A

March 03, 1995
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources

N/A
Professional Resources

N/A
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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