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Medications for Nonketotic Hyperosmolar Syndrome

Other names: Diabetic Hyperglycemic Hyperosmolar Coma; HONK, hyperosmolar non-ketotic coma; NKHHC; Nonketotic Hyperglycemic Hyperosmolar Coma

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    What is Nonketotic Hyperosmolar Syndrome:  Nonketotic Hyperosmolar Syndrome is a complication seen in diabetes mellitus in which very marked hyperglycemia occurs (such as levels exceeding 800 mg/dL), causing osmotic shifts in water in brain cells, and resulting in coma. It can be fatal or lead to permanent neurologic damage. Ketoacidosis does not occur in these cases.

    Medications to treat Nonketotic Hyperosmolar Syndrome

    The following list of medications are in some way related to, or used in the treatment of this condition.

    Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
    insulin regular B N X Add review Rate

    Generic name: insulin regular systemic

    Brand names:  Humulin R, Novolin R

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: A-Z Drug Facts

     
    Humulin R B N X Add review Rate

    Generic name: insulin regular systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: Prescribing Information

     
    Novolin R B N X Add review Rate

    Generic name: insulin regular systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: Prescribing Information

     
    Humalog B N X Add review Rate

    Generic name: insulin lispro systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: AHFS DI Monograph, Prescribing Information

     
    Humalog KwikPen B N X Add review Rate

    Generic name: insulin lispro systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

     
    insulin aspart B N X Add review Rate

    Generic name: insulin aspart systemic

    Brand names:  Novolog, NovoLog FlexPen, NovoLog PenFill

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

     
    insulin lispro B N X Add review Rate

    Generic name: insulin lispro systemic

    Brand names:  Humalog, Humalog KwikPen

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

     
    Novolog B N X Add review Rate

    Generic name: insulin aspart systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: AHFS DI Monograph

     
    NovoLog FlexPen B N X Add review Rate

    Generic name: insulin aspart systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

     
    NovoLog PenFill B N X Add review Rate

    Generic name: insulin aspart systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

     
    Apidra C N X Add review Rate

    Generic name: insulin glulisine systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: AHFS DI Monograph, Prescribing Information

     
    Apidra Solostar C N X Add review Rate

    Generic name: insulin glulisine systemic

    Drug class: insulin

    For consumers: dosage, interactions, side effects

     
    insulin glulisine C N X Add review Rate

    Generic name: insulin glulisine systemic

    Brand names:  Apidra, Apidra Solostar

    Drug class: insulin

    For consumers: dosage, interactions, side effects

    For professionals: A-Z Drug Facts, AHFS DI Monograph

     

    Legend

    Off Label This medication may not be approved by the FDA for the treatment of this condition.
    Prescription Only / Over the Counter
    Rx Prescription Only
    OTC Over the Counter
    Rx/OTC Prescription or Over the Counter
    Pregnancy
    A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
    B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
    C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
    D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
    X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
    N FDA has not classified the drug.
    Controlled Substances Act Schedule
    N Is not subject to the Controlled Substances Act.
    1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
    2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
    3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
    4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
    5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
    Alcohol
    X Interacts with Alcohol.

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