Medications for Nonketotic Hyperosmolar Syndrome

Other names: Diabetic Hyperglycemic Hyperosmolar Coma; HONK, hyperosmolar non-ketotic coma; NKHHC; Nonketotic Hyperglycemic Hyperosmolar Coma

Nonketotic Hyperosmolar Syndrome is a complication seen in diabetes mellitus in which very marked hyperglycemia occurs (such as levels exceeding 800 mg/dL), causing osmotic shifts in water in brain cells, and resulting in coma. It can be fatal or lead to permanent neurologic damage. Ketoacidosis does not occur in these cases.

Drugs used to treat Nonketotic Hyperosmolar Syndrome

The following list of medications are in some way related to or used in the treatment of this condition.

Drug name	Rating	Reviews	Rx/OTC	Pregnancy	CSA	Alcohol
Novolog	Rate	Add review	Rx	B	N	X
Generic name: insulin aspart systemic Drug class: insulin For consumers: dosage, interactions, side effects

Humalog	Rate	Add review	Rx	B	N	X
Generic name: insulin lispro systemic Drug class: insulin For consumers: dosage, interactions, side effects For professionals: Prescribing Information

insulin lispro	Rate	Add review	Rx	B	N	X
Generic name: insulin lispro systemic Brand names: Humalog, Humalog KwikPen Drug class: insulin For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information

insulin regular	Rate	Add review	Rx/OTC	B	N	X
Generic name: insulin regular systemic Brand names: Humulin R, Novolin R Drug class: insulin For consumers: dosage, interactions, side effects For professionals: Prescribing Information

insulin aspart	Rate	Add review	Rx	B	N	X
Generic name: insulin aspart systemic Brand names: Novolog, NovoLog FlexPen, NovoLog PenFill Drug class: insulin For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information

Humulin R	Rate	Add review	OTC	B	N	X
Generic name: insulin regular systemic Drug class: insulin For consumers: dosage, interactions, side effects For professionals: Prescribing Information

insulin glulisine	Rate	Add review	Rx	C	N	X
Generic name: insulin glulisine systemic Brand name: Apidra Drug class: insulin For consumers: dosage, interactions, side effects For professionals: AHFS DI Monograph

Novolin R	Rate	Add review	OTC	B	N	X
Generic name: insulin regular systemic Drug class: insulin For consumers: dosage, interactions, side effects For professionals: Prescribing Information

Apidra	Rate	Add review	Rx	C	N	X
Generic name: insulin glulisine systemic Drug class: insulin For consumers: dosage, interactions, side effects For professionals: Prescribing Information

NovoLog FlexPen	Rate	Add review	Rx	B	N	X
Generic name: insulin aspart systemic Drug class: insulin For consumers: dosage, interactions, side effects

Humalog KwikPen	Rate	Add review	Rx	B	N	X
Generic name: insulin lispro systemic Drug class: insulin For consumers: dosage, interactions, side effects

NovoLog PenFill	Rate	Add review	Rx	B	N	X
Generic name: insulin aspart systemic Drug class: insulin For consumers: dosage, interactions, side effects

Legend

Rating	For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity	Activity is based on recent site visitor activity relative to other medications in the list.
Rx	Prescription only.
OTC	Over-the-counter.
Rx/OTC	Prescription or Over-the-counter.
Off-label	This medication may not be approved by the FDA for the treatment of this condition.
EUA	An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.

Pregnancy Category
A	Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B	Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C	Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D	There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X	Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N	FDA has not classified the drug.

Controlled Substances Act (CSA) Schedule
M	The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U	CSA Schedule is unknown.
N	Is not subject to the Controlled Substances Act.
1	Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2	Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3	Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4	Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5	Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.

Alcohol
X	Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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