Apidra Dosage

Generic name: INSULIN GLULISINE 100[iU] in 1mL
Dosage form: injection, solution
Drug class: Insulin

Medically reviewed by Drugs.com. Last updated on Jul 25, 2023.

Always check insulin label before administration.
Inspect visually for particulate matter and discoloration. Only use APIDRA if the solution appears clear and colorless.
Use APIDRA SoloStar prefilled pen with caution in patients with visual impairment who may rely on audible clicks to dial their dose.

Subcutaneous Injection

Inject APIDRA subcutaneously within 15 minutes before a meal or within 20 minutes after starting a meal into the abdominal wall, thigh, or upper arm.
Rotate injection sites within the same region from one injection to the next to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis.
APIDRA given by subcutaneous injection should generally be used in regimens with an intermediate or long-acting insulin.
The APIDRA SoloStar prefilled pen dials in 1-unit increments.
Do not mix APIDRA for subcutaneous injection with insulins other than NPH insulin. If APIDRA is mixed with NPH insulin, draw APIDRA into the syringe first and inject immediately after mixing.

Continuous Subcutaneous Infusion (Insulin Pump)

Refer to the continuous subcutaneous insulin infusion pump user manual to see if APIDRA can be used with the insulin pump. Use APIDRA in accordance with the insulin pump system's instructions for use.
Administer APIDRA by continuous subcutaneous infusion in a region recommended in the instructions from the pump manufacturer. Rotate infusion sites within the same region to reduce the risk of lipodystrophy and localized cutaneous amyloidosis..
Train patients using continuous subcutaneous insulin infusion pump therapy to administer insulin by injection and have alternate insulin therapy available in case of insulin pump failure.
During changes to a patient's insulin regimen, increase the frequency of blood glucose monitoring.
Change APIDRA in the reservoir at least every 48 hours or according to the pump user manual, whichever is shorter.
Change the infusion sets and the infusion set insertion site according to the manufacturer's user manual.
Do not dilute or mix APIDRA when administering by continuous subcutaneous infusion.
Do not expose APIDRA in the pump reservoir to temperatures greater than 98.6°F (37°C).

Intravenous Administration

Administer APIDRA intravenously only under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia.
Dilute APIDRA to concentrations from 0.05 unit/mL to 1 unit/mL insulin glulisine in infusion systems using polyvinyl chloride (PVC) infusion bags.
Diluted APIDRA is stable at room temperature for 48 hours only in normal saline solution (0.9% Sodium Chloride Injection, USP).
APIDRA is not compatible with Dextrose solution and Ringers solution.

Individualize and adjust the dosage of APIDRA based on the patient's metabolic needs, blood glucose monitoring results, and glycemic control goal.
Dose adjustments may be needed when switching from another insulin, with changes in physical activity, changes in concomitant medications, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function, or during acute illness to minimize the risk of hypoglycemia or hyperglycemia.