Comparing Levaquin vs Penicillin VK

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Levaquin (levofloxacin)	Penicillin VK (penicillin v potassium)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Levaquin (levofloxacin)	Penicillin VK (penicillin v potassium)	Enter another drug to compare
Prescription only Levaquin treats a wide range of bacterial infections; however, it can cause some very severe and potentially irreversible side effects and should only be used to treat infections that have not... View more	Prescription only Prescribed for Bacterial Infection, Fusospirochetosis - Trench Mouth, Clostridioides difficile Infection, Cutaneous Bacillus anthracis, Lyme Disease - Erythema Chronicum Migrans, Middle Ear... View more	Related suggestions Bacterial Infection Amoxicillin Doxycycline Clindamycin Cephalexin Ciprofloxacin Metronidazole Skin or Soft Tissue Infection Cephalexin Doxycycline Clindamycin Keflex Amoxicillin Augmentin Pneumonia Levofloxacin Clarithromycin Azithromycin Doxycycline Ceftriaxone Amoxicillin Middle Ear Infections (Otitis Media) Amoxicillin Amoxicillin / clavulanate Cefdinir Ciprodex Azithromycin Augmentin Popular comparisons Levaquin vs ceftriaxone Levaquin vs levofloxacin Levaquin vs clarithromycin
More about Levaquin (levofloxacin)	More about Penicillin VK (penicillin v potassium)
Ratings & Reviews
Levaquin has an average rating of 5.3 out of 10 from a total of 410 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 43% reported a negative effect.	Penicillin VK has an average rating of 6.5 out of 10 from a total of 31 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 32% reported a negative effect.
View all 410 reviews	View all 31 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Pain (12.0%) Insomnia (10.0%) Dizziness (8.5%) Joint pain (7.8%) Anxiety (7.6%) Nausea (6.6%) Headaches (5.9%) View all Levaquin side effects	View all Penicillin VK side effects
Drug Class
Quinolones and fluoroquinolones	Natural penicillins
Generic Availability
Lower cost generic approved	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral solution Oral tablet	N/A
Brand Names
N/A	N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
6 hours	1 hour
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	B Category B No proven risk in humans See the full pregnancy warnings document.
Drug Interactions
A total of 527 drugs are known to interact with Levaquin: 117 major drug interactions (506 brand and generic names) 343 moderate drug interactions (2830 brand and generic names) 67 minor drug interactions (168 brand and generic names)	A total of 63 drugs are known to interact with Penicillin VK: 7 major drug interactions (25 brand and generic names) 50 moderate drug interactions (273 brand and generic names) 6 minor drug interactions (33 brand and generic names)
Alcohol/Food/Lifestyle Interactions
When levoFLOXacin as the oral solution is given with enteral (tube) feedings, levoFLOXacin may not... View more	No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
Colitis CNS disorders Myasthenia gravis Peripheral neuropathy QT interval prolongation Tendonitis Crystalluria Diabetes Hemodialysis Renal dysfunction	Colitis Asthma/allergies
First Approval Date
December 20, 1996	N/A
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group
Patient Resources
Levaquin uses	Penicillin VK uses
Professional Resources
Prescribing information	Prescribing information
Related Treatment Guide
Bacterial Infection Bladder Infection Anthrax Anthrax Prophylaxis Bronchitis Chlamydia Infection Epididymitis - Sexually Transmitted Gonococcal Infection - Disseminated Gonococcal Infection - Uncomplicated Kidney Infections Middle Ear Infections Nongonococcal Urethritis Nosocomial Pneumonia Pelvic Inflammatory Disease Plague Plague Prophylaxis Pneumonia Prostatitis Sinusitis Skin or Soft Tissue Infection Streptococcal Infection Tuberculosis - Active Urinary Tract Infection show all	Bacterial Infection Fusospirochetosis - Trench Mouth Clostridioides difficile Infection Cutaneous Bacillus anthracis Lyme Disease - Erythema Chronicum Migrans Middle Ear Infections Pneumonia Rat-bite Fever Rheumatic Fever Prophylaxis Skin or Soft Tissue Infection Streptococcal Infection Tonsillitis/Pharyngitis Upper Respiratory Tract Infection show all

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Comparing Levaquin vs Penicillin VK

See also:

Cefdinir

Amoxicillin/clavulanate

Botox

Clindamycin

Augmentin

Metronidazole

Ceftriaxone

Ciprofloxacin

Cephalexin

Azithromycin

Further information

Comparing Levaquin vs Penicillin VK

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