Levaquin Side Effects
Generic Name: levofloxacin
Note: This document contains side effect information about levofloxacin. Some of the dosage forms listed on this page may not apply to the brand name Levaquin.
More frequent side effects include: diarrhea and insomnia. See below for a comprehensive list of adverse effects.
WARNINGS: Levaquin may rarely cause tendon damage (such as tendinitis, tendon rupture) during or after treatment. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have had a kidney, heart or lung transplant. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling.
Levaquin should not be used in patients with myasthenia gravis. It may cause the condition to become worse. Seek immediate medical attention if you develop muscle weakness or trouble breathing.
For the Consumer
Applies to levofloxacin: oral solution, oral tablet
Other dosage forms:
Along with its needed effects, levofloxacin (the active ingredient contained in Levaquin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking levofloxacin:
- diarrhea (watery and severe) which may also be bloody
- feeling that others can hear your thoughts or control your behavior
- pain, inflammation, or swelling in the calves of the legs, shoulders, or hands, including tendon rupture or swelling of the tendon (tendinitis)
- redness and swelling of the skin
- seeing, hearing, or feeling things that are not there
- sensation of burning on the skin
- severe mood or mental changes
- stomach cramps or pain (severe)
- skin rash, itching, or redness
- unusual behavior
Incidence Not Known
- Black, tarry stools
- blurred vision
- burning, numbness, tingling, or painful sensation including peripheral neuropathy.
- dark urine
- difficulty with breathing
- difficulty with chewing, talking, or swallowing
- drooping eyelids
- fast or irregular heartbeat
- general body swelling
- joint or muscle pain including tendon rupture or swelling of the tendon (tendinitis).
- muscle cramps, spasms, pain, or stiffness
- peeling or loosening of the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- severe dizziness
- severe tiredness
- tightness in the chest
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- vision changes
- voice changes
- weakness in the arms, hands, legs, or feet including worsening of myasthenia gravis.
Some side effects of levofloxacin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Change in taste
- stomach pain or discomfort
- trouble sleeping
- vaginal itching and discharge
Incidence Not Known
- Feeling of warmth or heat
- flushing or redness of the skin, especially on the face and neck
For Healthcare Professionals
Applies to levofloxacin: compounding powder, intravenous solution, oral solution, oral tablet
The most frequently reported side effects with the IV and oral formulations included nausea, headache, diarrhea, insomnia, constipation, and dizziness. Therapy was discontinued due to side effects in 4.3% of patients overall (3.8% treated with 250 mg and 500 mg doses; 5.4% treated with 750 mg dose). The most common side effects leading to discontinuation were gastrointestinal (primarily nausea, vomiting), dizziness, and headache.
Cough/productive cough, dysgeusia, and fatigue/asthenia were reported most often with the nebulizer solution formulation.[Ref]
During 1 study, C difficile-associated diarrhea occurred in 11 of 490 study patients (2.2%) receiving this drug.
Frequency not reported: Dry mouth, dysphagia, gastrointestinal hemorrhage, tongue edema, gastroesophageal reflux, melena, taste perversion, intestinal perforation, intestinal obstruction, C difficile-associated diarrhea, hemorrhagic diarrhea, enterocolitis
-Common (1% to 10%): Nausea, vomiting, abdominal pain, diarrhea, constipation
-Uncommon (0.1% to 1%): Retching, dyspepsia, flatulence, oral fungal infection[Ref]
Common (1% to 10%): Headache, dizziness
Rare (0.01% to 0.1%): Tinnitus
Frequency not reported: Abnormal coordination, coma, hypoesthesia, dysesthesia, weakness, involuntary muscle contractions, hyperesthesia, paralysis, speech disorder, stupor, encephalopathy, leg cramps, ataxia, migraine, seizures, benign intracranial hypertension, hearing loss, hearing impaired, peripheral sensory neuropathy/sensory axonal polyneuropathy, peripheral sensory motor neuropathy/sensorimotor axonal polyneuropathy, dyskinesia, extrapyramidal disorder, hypoglycemic coma
Postmarketing reports: Abnormal electroencephalogram (EEG), exacerbation of myasthenia gravis, anosmia, ageusia, parosmia, encephalopathy (isolated reports), pseudotumor cerebri, hypoacusis, peripheral neuropathy (sometimes irreversible)
-Very common (10% or more): Dysgeusia (30%)
-Common (1% to 10%): Headache, dizziness, tinnitus
-Uncommon (0.1% to 1%): Hyposmia, somnolence, hearing loss[Ref]
Cases of sensory or sensorimotor axonal polyneuropathy (affecting small and/or large axons) resulting in paresthesias, hypoesthesias, dysesthesias, and weakness have been reported.
One survey reported 33 cases of peripheral neuropathy associated with this drug, ranging in severity from mild and reversible to severe and persistent. In 1 case, a 51-year-old female developed "electrical" sensations, numbness, allodynia, multiple severe tendinitis, partial tendon rupture, impaired memory, confusion, and impaired concentration, with some symptoms persisting after 1 year.[Ref]
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Abnormal dreams, agitation, anxiety, confusional state, nervousness, depression, hallucination, nightmare, sleep disorder
Rare (0.01% to 0.1%): Psychotic reactions (with hallucination, paranoia)
Frequency not reported: Aggressive reaction, delirium, emotional lability, impaired concentration, manic reaction, mental deficiency, toxic psychoses, withdrawal syndrome, psychotic disorders/reactions with self-endangering behavior (including suicidal ideation, suicide attempt)
Postmarketing reports: Psychosis, paranoia, suicide attempt (isolated reports), suicidal ideation (isolated reports), completed suicide (isolated reports)
-Common (1% to 10%): Insomnia
-Uncommon (0.1% to 1%): Anxiety, depression[Ref]
Mucocutaneous reactions have been reported, sometimes after the first dose.
A 78-year-old female developed toxic epidermal necrolysis 2 days after parenteral therapy. The rash initially manifested as an erythematous rash, blistering, and mucosal sloughing but progressed to exfoliation involving three-quarters of the patient's body surface area including mucosa. A positive Nikolsky sign was noted.
A 15-year-old male developed fatal toxic epidermal necrolysis taking this drug for 9 days. The rash progressed over 40 hours to involve 80% of his body surface area with a positive Nikolsky sign and involvement of the eyes and oral, nasal, and perianal mucosa.[Ref]
Common (1% to 10%): Rash, pruritus
Rare (0.01% to 0.1%): Angioedema
Postmarketing reports: Photosensitivity/phototoxicity reaction, bullous eruptions (including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, fixed drug eruptions, erythema multiforme), leukocytoclastic vasculitis
-Common (1% to 10%): Rash
-Uncommon (0.1% to 1%): Urticaria, pruritus[Ref]
Achilles tendon rupture occurred in 4 of 489 study patients (3217 treatment days) after 1 to 10 days of this drug.
Severe rhabdomyolysis occurred in a 77-year-old female after 6 days of oral therapy. She developed acute renal failure (serum creatinine 678 micromole/L), hyperkalemia (6.8 micromole/L), anuria, elevated creatine kinase (30,400 international units/L), myoglobinemia (86,000 mcg/L), and acute hepatic cytolysis (AST 555 international units/L, ALT 249 international units/L). The fluid/electrolyte disorders and creatine kinase and myoglobin levels improved with hemodialysis; however, the patient died of a myocardial infarction and respiratory failure after 13 days.[Ref]
Uncommon (0.1% to 1%): Arthralgia, myalgia, skeletal pain, tendinitis
Rare (0.01% to 0.1%): Tendon disorders (including tendinitis [e.g., Achilles tendon]), muscular weakness
Postmarketing reports: Tendon rupture (e.g., Achilles tendon), muscle injury (including rupture), increased muscle enzymes, rhabdomyolysis
-Common (1% to 10%): Arthralgia, myalgia
Ventricular arrhythmia and torsade de pointes have been reported, mainly in patients with risk factors of QT prolongation.
This drug was associated with 13 cases of torsade de pointes reported to the FDA between 1996 and 2001.
An 88-year-old woman developed a prolonged QTc interval during treatment with this drug (500 mg once a day). The QTc interval increased from 450 msec to 577 msec by the fourth day of treatment. This drug was discontinued after the patient experienced runs of ventricular tachycardia. The QTc interval then decreased to 437 msec 2 days after discontinuing this drug.
A 65-year-old woman with hypokalemia (2.8 mEq/L), hypomagnesemia (1.5 mEq/L), and renal insufficiency (serum creatinine 7.7 mg/dL, BUN 34 mg/dL) developed a QTc interval of 605 ms (baseline 435 to 485 ms), several episodes of torsade de pointes, and cardiac arrest after 3 days of this drug (250 mg/day IV). The QTc interval decreased to 399 ms and no further arrhythmias occurred after discontinuation of this drug and electrolyte replacement.
Common (1% to 10%): Phlebitis
Rare (0.01% to 0.1%): Tachycardia, hypotension
Frequency not reported: Angina pectoris, arrhythmia, atrial fibrillation, bradycardia, cardiac failure, cerebrovascular disorder, circulatory failure, coronary thrombosis, heart block, hypertension, aggravated hypertension, myocardial infarction, postural hypotension, purpura, supraventricular tachycardia, deep thrombophlebitis, vasculitis, ventricular fibrillation
Postmarketing reports: Vasodilation, QT interval prolongation/prolonged ECG QT, torsade de pointes
-Uncommon (0.1% to 1%): Tachycardia, prolonged ECG QT[Ref]
Decreased weight was reported during clinical trials for the nebulizer solution, but was primarily considered disease-related rather than drug-related.[Ref]
Common (1% to 10%): Chest pain, edema, moniliasis
Uncommon (0.1% to 1%): Asthenia, increased alkaline phosphatase, fungal infection (including Candida infection), pathogen resistance
Rare (0.01% to 0.1%): Pyrexia
Frequency not reported: Malaise, increased LDH, elevated serum triglycerides, elevated serum cholesterol, rigors, substernal chest pain, ascites, changed temperature sensation, ear disorder (unspecified), enlarged abdomen, hot flashes, gangrene, influenza-like symptoms, leg pain, multiple organ failure, earache, abscess, herpes simplex, bacterial infection, viral infection, otitis media, sepsis, pain (including pain in back, chest, extremities), fatigue, face edema, flushing, aggravated condition
Postmarketing reports: Multi-organ failure
-Very common (10% or more): Fatigue/asthenia (25%), decreased exercise tolerance, decreased weight
-Common (1% to 10%): Pyrexia
-Uncommon (0.1% to 1%): Increased blood alkaline phosphatase[Ref]
Common (1% to 10%): Increased hepatic enzymes (ALT/AST, alkaline phosphatase, GGT)
Uncommon (0.1% to 1%): Abnormal hepatic function, increased blood bilirubin
Postmarketing reports: Severe hepatotoxicity (including acute hepatitis and fatal events), hepatic failure (including fatal cases), hepatitis, jaundice
-Common (1% to 10%): Increased ALT, increased AST
Severe liver injury (including fatal cases with acute liver failure) has been reported, primarily in patients with severe underlying diseases.
A 74-year-old female developed hepatotoxicity and significantly increased AST (4962 units/L), ALT (7071 units/L), alkaline phosphatase (90 units/L), and total bilirubin (2.5 mg/dL) after starting this drug. Levels returned to normal within a week after discontinuation.
Severe hepatotoxicity usually occurred within 14 days (most within 6 days) after starting this drug and most cases were not associated with hypersensitivity. The majority of fatal hepatotoxicity cases occurred in patients 65 years or older and most were not associated with hypersensitivity.[Ref]
Uncommon (0.1% to 1%): Allergic reaction
Rare (0.01% to 0.1%): Hypersensitivity
Postmarketing reports: Hypersensitivity reactions (sometimes fatal and including anaphylactic/anaphylactoid reactions, anaphylactic/anaphylactoid shock, serum sickness, angioneurotic edema)
-Uncommon (0.1% to 1%): Hypersensitivity[Ref]
Anaphylactic and anaphylactoid reactions have been reported, sometimes after the first dose.[Ref]
Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Epistaxis
Frequency not reported: Rhinitis, sinusitis, pharyngitis, bronchitis, chronic obstructive airway disease, laryngitis, pleurisy, pneumonitis, upper respiratory tract infection, asthma, cough, hemoptysis, hiccough, hypoxia, pleural effusion, pulmonary embolism, respiratory insufficiency, airway obstruction, acute respiratory distress syndrome, aspiration, bronchospasm, emphysema, pneumonia, pneumothorax, pulmonary collapse, pulmonary edema, respiratory depression, respiratory disorder
Postmarketing reports: Allergic pneumonitis (isolated reports), dysphonia
-Very common (10% or more): Cough/productive cough (54%), dyspnea, changes in bronchial secretions (volume, viscosity), hemoptysis, decreased forced expiratory volume
-Common (1% to 10%): Dysphonia, decreased pulmonary function test, abnormal breath sounds
-Uncommon (0.1% to 1%): Bronchospasm, bronchial hyper-reactivity, obstructive airways disorder[Ref]
Rare (0.01% to 0.1%): Neutropenia
Frequency not reported: Decreased lymphocytes, abnormal WBCs (unspecified), abnormal platelets, agranulocytosis, hematoma, leukocytosis, lymphadenopathy, decreased prothrombin, purpura, thrombocythemia, serious hematological side effects (e.g., pancytopenia, agranulocytosis, hemolytic anemia)
Postmarketing reports: Hemolytic anemia, pancytopenia, aplastic anemia, prothrombin time prolonged, INR prolonged
-Uncommon (0.1% to 1%): Anemia, neutropenia, increased eosinophil count, decreased platelet count[Ref]
Serious hematological side effects (e.g., pancytopenia, agranulocytosis, hemolytic anemia) have been reported after systemic administration of this drug.[Ref]
Uncommon (0.1% to 1%): Abnormal renal function, acute renal failure (e.g., due to interstitial nephritis), increased blood creatinine
Frequency not reported: Renal calculi, allergic interstitial nephritis, increased nonprotein nitrogen
Postmarketing reports: Interstitial nephritis
-Common (1% to 10%): Increased blood creatinine
-Uncommon (0.1% to 1%): Renal failure[Ref]
A 73-year-old male developed vasculitis and acute renal failure within 3 days of starting oral therapy. Symptoms included significantly decreased urine output (0.5 to 0.7 L/day), palpable purpura, erythematous skin lesions, and increased serum creatinine (6.4 mg/dL) and BUN (190 mg/dL). The condition resolved within 4 weeks after discontinuation of this drug. Due to the possibility that this may have been an allergic reaction, rechallenge was not attempted.[Ref]
Uncommon (0.1% to 1%): Anorexia, hyperglycemia, hyperkalemia, hypoglycemia
Frequency not reported: Decreased blood glucose, hypomagnesemia, thirst, aggravated diabetes mellitus, dehydration, hypokalemia, gout, hypernatremia, hypophosphatemia, weight decrease, fluid overload, hyponatremia, acidosis, symptomatic hypoglycemia, electrolyte abnormalities
-Very common (10% or more): Anorexia
-Common (1% to 10%): Increased and decreased blood glucose
Hypoglycemia has been reported, especially in diabetic patients.
A 79-year-old male with type 2 diabetes mellitus developed severe hypoglycemia (blood glucose 6 mg/dL) and became unresponsive 6 hours after receiving 1 dose of this drug (250 mg IV). Blood glucose levels subsequently ranged between 40 to 159 mg/dL with dextrose doses and infusions; however, he did not regain consciousness and expired 2 days later.
Attacks of porphyria in patients with porphyria have been associated with fluoroquinolone use.[Ref]
Common (1% to 10%): Vaginitis
Uncommon (0.1% to 1%): Genital moniliasis
Frequency not reported: Dysmenorrhea, hematuria, dysuria, oliguria, urinary incontinence, urinary retention, leukorrhea, genital pruritus, ejaculation failure, impotence, albuminuria, candiduria, crystalluria, cylindruria, vaginal candidiasis, urinary tract infection
-Common (1% to 10%): Vulvovaginal mycotic infection[Ref]
Rare (0.01% to 0.1%): Visual disturbances (e.g., blurred vision)
Postmarketing reports: Vision disturbance (including diplopia), reduced visual acuity, blurred vision, scotomata, uveitis
-Uncommon (0.1% to 1%): Visual disturbance[Ref]
Frequency not reported: Carcinoma[Ref]
Common (1% to 10%): Injection site reactions (pain, reddening)
Frequency not reported: Injection site pain, injection site inflammation[Ref]
1. Croom KF, Goa KL "Levofloxacin: A Review of its Use in the Treatment of Bacterial Infections in the United States." Drugs 63 (2003): 2769-2802
2. "Product Information. Levaquin (levofloxacin)." Ortho Pharmaceutical Corporation, Raritan, NJ.
3. Yagawa K "Latest industry information on the safety profile of levofloxacin in Japan." Chemotherapy 47 Suppl 3 (2001): 38-43
4. Kahn JB "Latest industry information on the safety profile of levofloxacin in the US." Chemotherapy 47 Suppl 3 (2001): 32-7
5. Klimberg IW, Cox CE, Fowler CL, King W, Kim SS, CalleryDAmico S "A controlled trial of levofloxacin and lomefloxacin in the treatment of complicated urinary tract infection." Urology 51 (1998): 610-5
6. Sydnor TA, Kopp EJ, Anthony KE, LoCoco JM, Kim SS, Fowler CL "Open-label assessment of levofloxacin for the treatment of acute bacterial sinusitis in adults." Ann Allergy Asthma Immunol 80 (1998): 357-62
7. Chien SC, Wong FA, Fowler CL, CalleryDAmico SV, Williams RR, Nayak R, Chow AT "Double-blind evaluation of the safety and pharmacokinetics of multiple oral once-daily 750-milligram and 1-gram doses of levofloxacin in healthy volunteers." Antimicrob Agents Chemother 42 (1998): 885-8
8. Marra F, Marra CA, Moadebi S, et al. "Levofloxacin treatment of active tuberculosis and the risk of adverse events." Chest 128 (2005): 1406-13
9. Gopal Rao G, Mahankali Rao CS, Starke I "Clostridium difficile-associated diarrhoea in patients with community-acquired lower respiratory infection being treated with levofloxacin compared with beta-lactam-based therapy." J Antimicrob Chemother 51 (2003): 697-701
10. Sato A, Ogawa H, Iwata M, Ono T, Yasuda K, Nagayama M, Shirai T, Shirai M, Ida M, Suda T, et al "Clinical efficacy of levofloxacin in elderly patients with respiratory tract infections." Drugs 49(suppl 2 (1995): 428-9
11. Anderson VR, Perry CM "Levofloxacin : a review of its use as a high-dose, short-course treatment for bacterial infection." Drugs 68 (2008): 535-65
12. Goodwin SD, Gallis HA, Chow AT, Wong FA, Flor SC, Bartlett JA "Pharmacokinetics and safety of levofloxacin in patients with human immunodeficiency virus infection." Antimicrob Agents Chemother 38 (1994): 799-804
13. Shams WE, Evans ME "Guide to Selection of Fluoroquinolones in Patients with Lower Respiratory Tract Infections." Drugs 65 (2005): 949-991
14. Adelglass J, Jones TM, Ruoff G, et al. "A multicenter, investigator-blinded, randomized comparison of oral levofloxacin and oral clarithromycin in the treatment of bacterial sinusitis." Pharmacotherapy 18 (1998): 1255-63
15. Cohen JS "Peripheral neuropathy associated with fluoroquinolones." Ann Pharmacother 35 (2001): 1540-7
16. Bellon A, Perez-Garcia G, Coverdale JH, Chacko RC "Seizures associated with levofloxacin: case presentation and literature review." Eur J Clin Pharmacol 65 (2009): 959-62
17. Bird SB, Orr PG, Mazzola JL, Brush DE, Boyer EW "Levofloxacin-Related Seizure Activity in a Patient With Alzheimer's Disease: Assessment of Potential Risk Factors." J Clin Psychopharmacol 25 (2005): 287-288
18. Kawai T "Clinical evaluation of levofloxacin 200 mg 3 times daily in the treatment of bacterial lower respiratory tract infections." Drugs 49(suppl 2 (1995): 416-7
19. Corral De La Calle M, Martin Diaz MA, Flores CR, Vidaurrazaga C "Acute localized exanthematous pustulosis secondary to levofloxacin." Br J Dermatol 152 (2005): 1076-7
20. Boccumini LE, Fowler CL, Campbell TA, Puertolas LF, Kaidbey KH "Photoreaction potential of orally administered levofloxacin in healthy subjects." Ann Pharmacother 34 (2000): 453-8
21. Islam AS, Rahman MS "Levofloxacin-induced fatal toxic epidermal necrolysis." Ann Pharmacother 39 (2005): 1136-7
22. Dawe RS, Ibbotson SH, Sanderson JB, Thomson EM, Ferguson J "A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity." Br J Dermatol 149 (2003): 1232-41
23. Digwood-Lettieri S, Reilly KJ, Haith LR Jr, et al. "Levofloxacin-induced toxic epidermal necrolysis in an elderly patient." Pharmacotherapy 22 (2002): 789-93
24. Maunz G, Conzett T, Zimmerli W "Cutaneous vasculitis associated with fluoroquinolones." Infection 37 (2009): 466-8
25. Hsiao SH, Chang CM, Tsao CJ, Lee YY, Hsu MY, Wu TJ "Acute rhabdomyolysis associated with ofloxacin/levofloxacin therapy." Ann Pharmacother 39 (2004): 146-9
26. Mathis AS, Chan V, Gryszkiewicz M, Adamson RT, Friedman GS "Levofloxacin-Associated Achilles Tendon Rupture." Ann Pharmacother 37 (2003): 1014-1017
27. Lewis JR, Gums JG, Dickensheets DL "Levofloxacin-induced bilateral achilles tendonitis." Ann Pharmacother 33 (1999): 792-5
28. Haddow LJ, Chandra Sekhar M, Hajela V, Gopal Rao G "Spontaneous Achilles tendon rupture in patients treated with levofloxacin." J Antimicrob Chemother 51 (2003): 747-8
29. Vyas H, Krishnaswamy G "Images in clinical medicine. Quinolone-associated rupture of the Achilles' tendon." N Engl J Med 357 (2007): 2067
30. Petitjeans F, Nadaud J, Perez JP, et al. "A case of rhabdomyolysis with fatal outcome after a treatment with levofloxacin." Eur J Clin Pharmacol 59 (2003): 779-80
31. Fleisch E, Hartmann K, Kuhn M "Fluouroquinolone-induced tendinopathy: Also occurring with levofloxacin." Infection 28 (2000): 256-7
32. Khaliq Y, Zhanel GG "Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature." Clin Infect Dis 36 (2003): 1404-1410
33. Briasoulis A, Agarwal V, Pierce WJ "QT Prolongation and Torsade de Pointes Induced by Fluoroquinolones: Infrequent Side Effects from Commonly Used Medications." Cardiology 120 (2011): 103-110
34. Makaryus AN, Byrns K, Makaryus MN, Natarajan U, Singer C, Goldner B "Effect of ciprofloxacin and levofloxacin on the QT interval: is this a significant "clinical" event?" South Med J 99 (2006): 52-6
35. Berger RE "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." J Urol 174 (2005): 165
36. Amankwa K, Krishnan SC, Tisdale JE "Torsades de pointes associated with fluoroquinolones: Importance of concomitant risk factors." Clin Pharmacol Ther 75 (2004): 242-7
37. Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72
38. Abo-Salem E, Nugent K, Chance W "Antibiotic-induced cardiac arrhythmia in elderly patients." J Am Geriatr Soc 59 (2011): 1747-9
39. Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7
40. Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8; discussion 668-72
41. Ramakrishnan K, Scheid DC "Diagnosis and management of acute pyelonephritis in adults." Am Fam Physician 71 (2005): 933-42
42. Owens RC Jr, Nolin TD "Antimicrobial-Associated QT Interval Prolongation: Pointes of Interest." Clin Infect Dis 43 (2006): 1603-1611
43. Samaha FF "QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin." Am J Med 107 (1999): 528-9
44. Lapi F, Wilchesky M, Kezouh A, Benisty JI, Ernst P, Suissa S "Fluoroquinolones and the risk of serious arrhythmia: a population-based study." Clin Infect Dis 55 (2012): 1457-65
45. Coban S, Ceydilek B, Ekiz F, Erden E, Soykan I "Levofloxacin-induced acute fulminant hepatic failure in a patient with chronic hepatitis B infection." Ann Pharmacother 39 (2005): 1737-40
46. Karim A, Ahmed S, Rossoff LJ, Siddiqui RK, Steinberg HN "Possible levofloxacin-induced acute hepatocellular injury in a patient with chronic obstructive lung disease." Clin Infect Dis 33 (2001): 2088-90
47. Paterson JM, Mamdani MM, Manno M, Juurlink DN "Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study." CMAJ 184 (2012): 1565-70
48. Solomon NM, Mokrzycki MH "Levofloxacin-induced allergic interstitial nephritis." Clin Nephrol 54 (2000): 356
49. Oh YR, Carr-Lopez SM, Probasco JM, Crawley PG "Levofloxacin-induced autoimmune hemolytic anemia." Ann Pharmacother 37 (2003): 1010-3
50. Famularo G, De Simone C "Nephrotoxicity and purpura associated with levofloxacin." Ann Pharmacother 36 (2002): 1380-2
51. Singh N, Jacob JJ "Levofloxacin and hypoglycemia." Clin Infect Dis 46 (2008): 1127
52. Laplante KL, Mersfelder TL, Ward KE, Quilliam BJ "Prevalence of and risk factors for dysglycemia in patients receiving gatifloxacin and levofloxacin in an outpatient setting." Pharmacotherapy 28 (2008): 82-9
53. Lodise T, Graves J, Miller C, Mohr JF, Lomaestro B, Smith RP "Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients." Pharmacotherapy 27 (2007): 1498-505
54. Graumlich JF, Habis S, Avelino RR, et al. "Hypoglycemia in inpatients after gatifloxacin or levofloxacin therapy: nested case-control study." Pharmacotherapy 25 (2005): 1296-302
55. Kelesidis T, Canseco E "Quinolone-induced hypoglycemia: a life-threatening but potentially reversible side effect." Am J Med 123 (2010): e5-6
56. Micheli L, Sbrilli M, Nencini C "Severe hypoglycemia associated with levofloxacin in Type 2 diabetic patients receiving polytherapy: two case reports." Int J Clin Pharmacol Ther 50 (2012): 302-6
57. Kelesidis T, Canseco E "Levofloxacin-induced hypoglycemia: a rare but life-threatening side effect of a widely used antibiotic." Am J Med 122 (2009): e3-4
58. Gibert AE, Porta FS "Hypoglycemia and levofloxacin: a case report." Clin Infect Dis 46 (2008): 1126-7
59. Friedrich LV, Dougherty R "Fatal hypoglycemia associated with levofloxacin." Pharmacotherapy 24 (2004): 1807-12
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
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