Comparing Leflunomide vs Otezla
| Leflunomide | Otezla (apremilast) |
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| Leflunomide | Otezla (apremilast) |
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Prescription only
Prescribed for Rheumatoid Arthritis, Psoriatic Arthritis. Leflunomide may also be used for purposes not listed in this medication guide. |
Prescription only
Otezla is a PDE4 inhibitor that may be used to treat adults with plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s Disease. It may also be used to treat plaque psoriasis... View more |
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| More about Leflunomide | More about Otezla (apremilast) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Leflunomide has an average rating of 5.1 out of 10 from a total of 116 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 46% reported a negative effect. |
Otezla has an average rating of 5.2 out of 10 from a total of 443 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Leflunomide side effects |
View all Otezla side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Leflunomide prices |
View all Otezla prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Arava |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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336 hours |
9 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 681 drugs are known to interact with Leflunomide:
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A total of 111 drugs are known to interact with Otezla:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 10, 1998 |
March 21, 2014 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.