Glimepiride Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Glimepiride	Mounjaro (tirzepatide)	Semaglutide	Enter another drug to compare

Glimepiride

Mounjaro (tirzepatide)

Semaglutide

Prescription only

Glimepiride is used to help maintain blood sugar control in people with type 2 diabetes. It may cause nausea and people who take glimepiride should always be alert for symptoms of hypoglycemia (low... View more

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

Prescription only

Semaglutide (Ozempic, Rybelsus) lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the... View more

More about Glimepiride

More about Mounjaro (tirzepatide)

More about Semaglutide

Ratings & Reviews

Glimepiride has an average rating of 6.7 out of 10 from a total of 71 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.

Mounjaro has an average rating of 8.5 out of 10 from a total of 1449 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 6% reported a negative effect.

Semaglutide has an average rating of 6.9 out of 10 from a total of 2769 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 20% reported a negative effect.

View all 71 reviews

View all 1449 reviews

View all 2769 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Blood sugar (8.5%)
Weight gain (8.5%)
Stomach pain (7.0%)
Diarrhea (5.6%)
Upset stomach (4.2%)

View all Glimepiride side effects

Nausea (16.3%)
Constipation (11.7%)
Diarrhea (8.2%)
Loss of appetite (4.6%)
Upset stomach (4.5%)
Vomiting (4.4%)
Burping (3.9%)

View all Mounjaro side effects

Nausea (33.4%)
Constipation (15.1%)
Diarrhea (14.8%)
Vomiting (10.9%)
Headaches (6.8%)
Burping (6.7%)
Upset stomach (6.2%)

View all Semaglutide side effects

Drug Class

Sulfonylureas

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

Lower cost generic

No lower cost generic approved

N/A

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	4 mg
Per unit^*	$0.26
Cost^*	$12.96

View all Glimepiride prices

Quantity	2 mL
Strength	2.5 mg/0.5 mL
Per unit^*	$531.31
Cost^*	$1,062.62

View all Mounjaro prices

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Dosage Forms

Oral tablet

Subcutaneous solution

N/A

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.4 hours

120 hours

168 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 505 drugs are known to interact with Glimepiride:

24 major drug interactions (62 brand and generic names)
466 moderate drug interactions (2434 brand and generic names)
15 minor drug interactions (106 brand and generic names)

A total of 416 drugs are known to interact with Mounjaro:

16 major drug interactions (37 brand and generic names)
399 moderate drug interactions (2282 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 275 drugs are known to interact with Semaglutide:

16 major drug interactions (37 brand and generic names)
258 moderate drug interactions (1457 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

November 30, 1995

N/A

December 05, 2017

WADA Class View classifications

N/A

More Information

Patient Resources

Glimepiride uses

Mounjaro uses

Semaglutide uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Glimepiride Alternatives Compared

See also:

Ozempic

Trulicity

Mounjaro

Lantus

Tresiba

Levemir

Victoza

Basaglar

Novolog

Soliqua

Further information

Glimepiride Alternatives Compared

See also:

Further information

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