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Glimepiride Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Glimepiride Metformin Ozempic
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Glimepiride Metformin Ozempic (semaglutide)
Prescription only

Glimepiride is used to help maintain blood sugar control in people with type 2 diabetes. It may cause nausea and people who take glimepiride should always be alert for symptoms of hypoglycemia (low... View more

Prescription only

Metformin improves how the body responds to insulin and it is effective for the treatment of type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

More about Glimepiride More about Metformin More about Ozempic (semaglutide)
Ratings & Reviews

Glimepiride has an average rating of 6.8 out of 10 from a total of 71 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 24% reported a negative effect.

Metformin has an average rating of 6.9 out of 10 from a total of 647 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 19% reported a negative effect.

Ozempic has an average rating of 6.5 out of 10 from a total of 1304 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 26% reported a negative effect.

View all 71 reviews

View all 647 reviews

View all 1304 reviews

Drug Class
Side Effects

See also: glimepiride side effects in more detail.

See also: metformin side effects in more detail.

See also: Ozempic side effects in more detail.
Generic Availability

Lower cost generic

Lower cost generic

No lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Dosage 4 mg
Per Unit* $0.51
Cost* $25.53

View all glimepiride prices

Quantity 100 each
Dosage 500 mg
Per Unit* $0.16 - $0.22
Cost* $16.02 - $22.18

View all metformin prices

Quantity 1.5 mL
Dosage 2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per Unit* $686.23
Cost* $1,029.35

View all Ozempic prices

Get free Discount Card

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Dosage Forms Available
  • Oral tablet
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
  • Subcutaneous solution
Brand Names
Amaryl Glumetza Other semaglutide brands include: Rybelsus, Wegovy
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

3.4 hours

4.5 hours

168 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 466 drugs are known to interact with glimepiride:

  • 23 major drug interactions (59 brand and generic names)
  • 428 moderate drug interactions (2256 brand and generic names)
  • 15 minor drug interactions (106 brand and generic names)

A total of 367 drugs are known to interact with metformin:

  • 24 major drug interactions (128 brand and generic names)
  • 334 moderate drug interactions (1757 brand and generic names)
  • 9 minor drug interactions (35 brand and generic names)

A total of 264 drugs are known to interact with Ozempic:

  • 15 major drug interactions (34 brand and generic names)
  • 248 moderate drug interactions (1421 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more
  • MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more
  • Semaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
Disease Interactions
First Approval Date

November 30, 1995

March 03, 1995

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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