Comparing Fluoxetine vs Sertraline
| Fluoxetine | Sertraline |
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| Fluoxetine | Sertraline |
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Prescription only
Fluoxetine treats major depression (adults/children 8+), OCD (adults/children 7+), bulimia nervosa, and panic disorder. More likely to cause insomnia than drowsiness. There is a risk of serotonin... View more |
Prescription only
Sertraline is used to treat mood disorders such as depression, anxiety, OCD, PTSD, panic disorder, and premenstrual dysphoric disorder (PMDD). Headaches, nausea, diarrhea, weight loss, insomnia... View more |
Related suggestions Depression
Major Depressive Disorder
Anxiety and Stress
Panic Disorder
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| More about Fluoxetine | More about Sertraline | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Fluoxetine has an average rating of 7.3 out of 10 from a total of 2251 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 18% reported a negative effect. |
Sertraline has an average rating of 7.3 out of 10 from a total of 4605 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Fluoxetine side effects |
View all Sertraline side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Fluoxetine prices |
View all Sertraline prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Prozac | Zoloft | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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210 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 684 drugs are known to interact with Fluoxetine:
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A total of 675 drugs are known to interact with Sertraline:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 29, 1987 |
December 30, 1991 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.