Comparing Estradiol vs Premarin
| Estradiol | Premarin |
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| Estradiol | Premarin (conjugated estrogens) |
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Prescription only
Estradiol is a synthetic form of estrogen that may be given for several different indications, including the relief of menopausal symptoms or low estrogen levels caused by other conditions. Its use... View more |
Prescription only
Prescribed for Atrophic Vaginitis, Abnormal Uterine Bleeding, Atrophic Urethritis, Breast Cancer - Palliative, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian... View more |
Related suggestions Postmenopausal Symptoms
Atrophic Vaginitis
Prostate Cancer
Oophorectomy
Popular comparisons
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| More about Estradiol | More about Premarin (conjugated estrogens) | ||||||||||||||||
| Generic Status | |||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | |||||||||||||||||
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Estradiol has an average rating of 5.8 out of 10 from a total of 522 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 39% reported a negative effect. |
Premarin has an average rating of 7.6 out of 10 from a total of 78 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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Commonly reported side effects include:
See also: estradiol side effects in more detail. |
See also: Premarin side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all estradiol prices |
View all Premarin prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Alora, Climara, Delestrogen, Depo-Estradiol, Divigel, Dotti, Elestrin, Estra Pellets, Estrace, Estraderm, Estradiol Patch, Estrogel, Evamist, Femring, Lyllana, Menostar, Minivelle, Vivelle-Dot View more | Other conjugated estrogens brands include: Premarin Intravenous | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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16 hours |
N/A |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 316 drugs are known to interact with estradiol:
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A total of 219 drugs are known to interact with Premarin:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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July 23, 1975 |
May 08, 1942 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.