Esketamine Alternatives Compared

Name: Esketamine Alternatives Compared
Creator: Drugs.com

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Esketamine	Rexulti (brexpiprazole)	Bupropion	Enter another drug to compare

Esketamine

Rexulti (brexpiprazole)

Bupropion

Prescription only

Prescribed for Depression, Major Depressive Disorder, Major Depressive Disorder with Acute Suicidal Ideation. Esketamine may also be used for purposes not listed in this medication guide.

Prescription only

Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more

Prescription only

Bupropion is used to treat major depressive disorder and seasonal affective disorder and is chemically distinct from other antidepressants. It is also used for smoking cessation, and is significantly... View more

More about Esketamine

More about Rexulti (brexpiprazole)

More about Bupropion

Ratings & Reviews

Esketamine has an average rating of 6.2 out of 10 from a total of 147 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect.

Rexulti has an average rating of 6.6 out of 10 from a total of 566 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 25% reported a negative effect.

Bupropion has an average rating of 7.0 out of 10 from a total of 2972 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect.

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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (10.9%)
Anxiety (8.8%)
Dizziness (6.1%)
Hallucinations (6.1%)
Headaches (4.8%)
Bad taste (4.1%)
Depression (4.1%)

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Weight gain (21.2%)
Anxiety (8.7%)
Insomnia (7.1%)
Tiredness (6.5%)
Restlessness (6.2%)
Increased appetite (4.6%)
Depression (4.4%)

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Anxiety (16.3%)
Insomnia (11.7%)
Headaches (7.2%)
Sexual dysfunction (6.2%)
Irritability (6.1%)
Loss of appetite (5.7%)
Depression (5.6%)

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Boxed Warnings A boxed warning is the most serious warning from the Food and Drug Administration (FDA) about drug effects that may be dangerous.

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Drug Class

Miscellaneous antidepressants

Atypical antipsychotics

Generic Availability Learn more about brand vs generic drugs.

N/A

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance.

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity	30 tablet
Strength	0.25 mg
Per unit^*	$50.92
Cost^*	$1,527.66
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Quantity	30 tablet, extended release
Strength	150 mg/24 hours
Per unit^*	$0.48
Cost^*	$14.40
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Dosage Forms

N/A

Oral tablet

Oral tablet
Oral tablet, extended release

Half Life Learn about the half-life of a drug and how it is calculated.

12 hours

91 hours

30 hours

CSA Schedule ¹ View glossary of CSA terms

Moderate abuse potential

Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category C
Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 302 drugs are known to interact with Esketamine:

269 major drug interactions (1292 brand and generic names)
33 moderate drug interactions (164 brand and generic names)

A total of 619 drugs are known to interact with Rexulti:

142 major drug interactions (528 brand and generic names)
473 moderate drug interactions (1871 brand and generic names)
4 minor drug interactions (104 brand and generic names)

A total of 578 drugs are known to interact with Bupropion:

221 major drug interactions (964 brand and generic names)
351 moderate drug interactions (1928 brand and generic names)
6 minor drug interactions (18 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Moderate interaction: Using esketamine together with alcohol may increase side effects such as drowsiness, confusion... View more

Moderate interaction: Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness... View more

Moderate interaction: Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

N/A

July 10, 2015

December 30, 1985

WADA Class View classifications

N/A

More Information

Patient Resources

Rexulti uses

Bupropion uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Esketamine Alternatives Compared

See also:

Vraylar

Lexapro

Rexulti

Zoloft

Seroquel

Wellbutrin

Cymbalta

Prozac

Concerta

Celexa

Further information

Esketamine Alternatives Compared

Related suggestions

Depression

Major Depressive Disorder

See also:

Further information