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Esketamine and Hallucinations: What Users Say

Brand names: Spravato

Hallucinations: mentioned by 8 users (5.9%)

Based on user experiences from 135 Esketamine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 11.1%
anxiety 8.1%
dizziness 6.7%
hallucinations 5.9%
bad taste 4.4%
headaches 4.4%
confusion 3.7%
depression 3.7%
drowsiness 3.7%
sick 3.7%

Reviews for Esketamine

Commonly mentioned side effects
  • Hop...
  • Taken for 1 to 6 months
  • October 2, 2019

Esketamine for Depression "TRD (treatment-resistant depression) for 30 years, have tried everything and will continue to try this. Was on 56mg 2x week for a month (eventually I had no immediate reaction as my body got used to the drug - lingering tiredness, so I did the treatments in the late afternoon) and have had 3 treatments with 84mg. First two of 84mg were fine - trippy, slight visual disturbance but I was able to recognize that this was the drug and not me - felt like I smoked a ton of pot or something. Yesterday was the 3rd treatment of 84mg. I went into the appointment very upset and stressed, and coupled with Spravato, had a dissociative episode. I started to cry and then boom: sobbing, no idea who I was, where I was, visual disturbance so couldn't see correctly, was paranoid, untrusting - I have never been so terrified in all my life. So far, no depression reduction, which saddens me, and I'm scared to have another trip like I did yesterday."

2 / 10
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  • Ril...
  • Taken for 1 to 6 months
  • October 4, 2021

Esketamine for Depression "I started taking Spravato in September 2019. I was hoping it would help with depression, bipolar, and PTSD. I completely changed into another person. I went into major psychosis and ended up in the psych ward five times from the end of December to mid-February. It was horrific and terrifying. I have lingering psychosis, and it’s been two years. I scared the shot out of my family, and there isn’t a day that goes by that it doesn’t scare me that this feeling will never go away. I also had gotten the flu really bad when I was hospitalized and had delusions I could write a book about. I would say not to take it, but everyone is different. Has anyone else had a scary reaction that has lasted two years? Has anyone else gone into major psychosis? (I felt I was gone a million years and saw Jesus and God and aliens, I also believed the world was gone and everyone was dead.)"

1 / 10
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  • Ril...
  • Taken for 1 to 6 months
  • October 4, 2021

Esketamine for Depression "I started taking Spravato in September 2019. I was hoping it would help with depression, bipolar, and PTSD. I completely changed into another person. I went into major psychosis and ended up in the psych ward five times from the end of December to mid-February. It was horrific and terrifying. I have lingering psychosis, and it’s been two years. I scared the shot out of my family, and there isn’t a day that goes by that it doesn’t scare me that this feeling will never go away. I also had gotten the flu really bad when I was hospitalized and had delusions I could write a book about. I would say not to take it, but everyone is different. Has anyone else had a scary reaction that has lasted two years? Has anyone else gone into major psychosis? (I felt I was gone a million years and saw Jesus and God and aliens, I also believed the world was gone and everyone was dead.)"

1 / 10
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Frequently asked questions

  • Des...
  • Taken for less than 1 month
  • July 4, 2022

Esketamine for Major Depressive Disorder "Spravato ended up making me have suicidal thoughts, and I think maybe go into a psychosis or something... I took it for a month. Twice in one week, 34 mg, and then the rest ones were 84 mg once a week. You take it like a nasal spray, and it burns a lot. I just couldn’t move and felt drunk, like mucked up, seeing tracers for about 45 minutes maybe. I didn’t like how I couldn’t move. I was completely numb, it helps pain for that time. But when it wore off, I was still numb mentally. I would get angry when it wore off. It just has to be known, it made me worse. They told me it was impossible to feel worse, which is so stupid. I also have PTSD, social anxiety, and generalized. Spravato made me take a lot of steps back. I had worked so hard to the point to where I was, and it tore it all down. Now I am a lot better and building it back up. But I just still don’t feel 100%. I hope I do. It made me aggressive, I wanted to fight people and harm myself. I used to be addicted to self-harming."

1 / 10
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  • Jam...
  • Taken for 1 to 6 months
  • September 6, 2021

For Major Depressive Disorder "I was on Spravato nasal for about four to six months. At the end of November 2019, insurance was cut off, and I ended up in psych wards with major, severe, horrible psychosis. Now we're in September 2021, and I am still having problems with hearing scary stuff. I felt/feel possessed. I have psychic abilities/paranoia, phobias? Intrusive voices, a lot of negative side effects. Am I stuck in the K hole? Has anyone else had horrific withdrawals and had it mess with your head? I thought I was crazy before, haha. I'm scared."

1 / 10
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  • Jam...
  • Taken for 1 to 6 months
  • September 6, 2021

For Major Depressive Disorder "I was on Spravato nasal for about four to six months. At the end of November 2019, insurance was cut off, and I ended up in psych wards with major, severe, horrible psychosis. Now we're in September 2021, and I am still having problems with hearing scary stuff. I felt/feel possessed. I have psychic abilities/paranoia, phobias? Intrusive voices, a lot of negative side effects. Am I stuck in the K hole? Has anyone else had horrific withdrawals and had it mess with your head? I thought I was crazy before, haha. I'm scared."

1 / 10
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  • Kat...
  • Taken for less than 1 month
  • June 16, 2022

For Depression "I tried 4 doses of high-dose esketamine. It was absolutely useless! Waste of time! Waste of money! The only effect I experienced was that it tasted bitter when it dripped down my throat. I did not have dissociations, hallucinations, nausea, drowsiness, dizziness, or anything else. My vital signs also never changed at all. I simply got angry because I was forced to sit in an empty room, bored silly for 2 hours each time. It did nothing for my depression, suicidal ideation, or panic attacks. Giving me bad-tasting saline would have the same effects as esketamine (and be much cheaper). I think it works purely on a placebo effect! I also haven't responded to numerous antidepressants, CBT, or any other treatments either."

1 / 10
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  • Mar...
  • Taken for 1 to 6 months
  • March 9, 2022

Esketamine for Depression "Horrible side effects. Paranoid, delusional, agitated all the time. Overwhelmed my sense."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.