Esketamine and Hallucinations: What Users Say

• Hop...
• Taken for 1 to 6 months
• October 2, 2019

Esketamine for Depression "TRD (treatment-resistant depression) for 30 years, have tried everything and will continue to try this. Was on 56mg 2x week for a month (eventually I had no immediate reaction as my body got used to the drug - lingering tiredness, so I did the treatments in the late afternoon) and have had 3 treatments with 84mg. First two of 84mg were fine - trippy, slight visual disturbance but I was able to recognize that this was the drug and not me - felt like I smoked a ton of pot or something. Yesterday was the 3rd treatment of 84mg. I went into the appointment very upset and stressed, and coupled with Spravato, had a dissociative episode. I started to cry and then boom: sobbing, no idea who I was, where I was, visual disturbance so couldn't see correctly, was paranoid, untrusting - I have never been so terrified in all my life. So far, no depression reduction, which saddens me, and I'm scared to have another trip like I did yesterday."

• Ril...
• Taken for 1 to 6 months
• October 4, 2021

Esketamine for Depression "I started taking Spravato in September 2019. I was hoping it would help with depression, bipolar, and PTSD. I completely changed into another person. I went into major psychosis and ended up in the psych ward five times from the end of December to mid-February. It was horrific and terrifying. I have lingering psychosis, and it’s been two years. I scared the shot out of my family, and there isn’t a day that goes by that it doesn’t scare me that this feeling will never go away. I also had gotten the flu really bad when I was hospitalized and had delusions I could write a book about. I would say not to take it, but everyone is different. Has anyone else had a scary reaction that has lasted two years? Has anyone else gone into major psychosis? (I felt I was gone a million years and saw Jesus and God and aliens, I also believed the world was gone and everyone was dead.)"

• Ril...
• Taken for 1 to 6 months
• October 4, 2021

Esketamine for Depression "I started taking Spravato in September 2019. I was hoping it would help with depression, bipolar, and PTSD. I completely changed into another person. I went into major psychosis and ended up in the psych ward five times from the end of December to mid-February. It was horrific and terrifying. I have lingering psychosis, and it’s been two years. I scared the shot out of my family, and there isn’t a day that goes by that it doesn’t scare me that this feeling will never go away. I also had gotten the flu really bad when I was hospitalized and had delusions I could write a book about. I would say not to take it, but everyone is different. Has anyone else had a scary reaction that has lasted two years? Has anyone else gone into major psychosis? (I felt I was gone a million years and saw Jesus and God and aliens, I also believed the world was gone and everyone was dead.)"

• Des...
• Taken for less than 1 month
• July 4, 2022

Esketamine for Major Depressive Disorder "Spravato ended up making me have suicidal thoughts, and I think maybe go into a psychosis or something... I took it for a month. Twice in one week, 34 mg, and then the rest ones were 84 mg once a week. You take it like a nasal spray, and it burns a lot. I just couldn’t move and felt drunk, like mucked up, seeing tracers for about 45 minutes maybe. I didn’t like how I couldn’t move. I was completely numb, it helps pain for that time. But when it wore off, I was still numb mentally. I would get angry when it wore off. It just has to be known, it made me worse. They told me it was impossible to feel worse, which is so stupid. I also have PTSD, social anxiety, and generalized. Spravato made me take a lot of steps back. I had worked so hard to the point to where I was, and it tore it all down. Now I am a lot better and building it back up. But I just still don’t feel 100%. I hope I do. It made me aggressive, I wanted to fight people and harm myself. I used to be addicted to self-harming."

• Jam...
• Taken for 1 to 6 months
• September 6, 2021

For Major Depressive Disorder "I was on Spravato nasal for about four to six months. At the end of November 2019, insurance was cut off, and I ended up in psych wards with major, severe, horrible psychosis. Now we're in September 2021, and I am still having problems with hearing scary stuff. I felt/feel possessed. I have psychic abilities/paranoia, phobias? Intrusive voices, a lot of negative side effects. Am I stuck in the K hole? Has anyone else had horrific withdrawals and had it mess with your head? I thought I was crazy before, haha. I'm scared."

• Jam...
• Taken for 1 to 6 months
• September 6, 2021

For Major Depressive Disorder "I was on Spravato nasal for about four to six months. At the end of November 2019, insurance was cut off, and I ended up in psych wards with major, severe, horrible psychosis. Now we're in September 2021, and I am still having problems with hearing scary stuff. I felt/feel possessed. I have psychic abilities/paranoia, phobias? Intrusive voices, a lot of negative side effects. Am I stuck in the K hole? Has anyone else had horrific withdrawals and had it mess with your head? I thought I was crazy before, haha. I'm scared."

• Kat...
• Taken for less than 1 month
• June 16, 2022

For Depression "I tried 4 doses of high-dose esketamine. It was absolutely useless! Waste of time! Waste of money! The only effect I experienced was that it tasted bitter when it dripped down my throat. I did not have dissociations, hallucinations, nausea, drowsiness, dizziness, or anything else. My vital signs also never changed at all. I simply got angry because I was forced to sit in an empty room, bored silly for 2 hours each time. It did nothing for my depression, suicidal ideation, or panic attacks. Giving me bad-tasting saline would have the same effects as esketamine (and be much cheaper). I think it works purely on a placebo effect! I also haven't responded to numerous antidepressants, CBT, or any other treatments either."

• Mar...
• Taken for 1 to 6 months
• March 9, 2022

Esketamine for Depression "Horrible side effects. Paranoid, delusional, agitated all the time. Overwhelmed my sense."