Esketamine and Drowsiness: What Users Say

• Inf...
• Taken for 1 to 6 months
• September 24, 2019

Esketamine for Depression "People need to understand that no one is the same and that everyone will have different reactions. Take me for example (then compare it to the experiences of others): Diagnosis: MDD & CPTSD Dose: 84 mg Duration: 4+ months Prior use of psychedelics: None As for me, I’ve found substantial relief for the first time ever (42 years of age). I’ve had 2 experiences of disassociation, which were extremely pleasant, controllable and very mild, at best. At no time have I had any “out-of-body” experiences, no dizziness, no side effects at all — other than mild sedation afterwards (for approximately 20-30 minutes). TMS did not work, nor did ECT or DBT. Ketamine infusions worked well, that is until I developed severe UTIs, kidney stones, and a PSA level of 9.8! I could go on and on, but the point of this review is to show the lack of correlation between my experience and those of others. BOTTOM LINE: WHEN IT COMES TO MENTAL HEALTH, NEVER TAKE THE ADVICE OF ONLINE REVIEWS."

• Sad...
• Taken for 1 to 6 months
• December 29, 2021

Esketamine for Major Depressive Disorder "First dose was like a light switch flipped on, and everything was in color again. Immediate end to all suicidal thoughts and ideations. Drastically improved sleep, and I was able to reduce other medications as a result. The rest of the treatments were beneficial, as the dissociation helped me process trauma that I just couldn't do with therapy alone. No side effects except drowsiness the day of treatment."

• Spu...
• February 4, 2020

For Depression "9 treatments. First three weeks, I felt some improvement. Laughing, having motivation. Once a week and feel less depressed for 3 days. Then depressed. Treatment feels amazing! Had IV infusions very intense! I couldn't feel my body. Crazy hallucinations, nothing scary. Enjoyable. Spravato, I feel relaxed like Pink Floyd's Comfortably Numb! No visual disturbances. Listen to Simon and Garfunkel, mellow but upbeat. No rock! I can feel my body, hearing is more sensitive. Music sounds great! Definitely a nasty taste in my throat. Candy helps. I stop feeling the effects after 1 hour, drowsy hour 2. Then normal but rest at home. Headphones and playlist, bring a soft blanket and eye mask. The experience is becoming less pleasurable. Antidepressant effect has been minimal. I wish I could have more IV, it was less $. Pure Ketamine is very helpful. For Spravato, they've taken away one of the molecules. Research it please."

• Kat...
• Taken for less than 1 month
• June 16, 2022

For Depression "I tried 4 doses of high-dose esketamine. It was absolutely useless! Waste of time! Waste of money! The only effect I experienced was that it tasted bitter when it dripped down my throat. I did not have dissociations, hallucinations, nausea, drowsiness, dizziness, or anything else. My vital signs also never changed at all. I simply got angry because I was forced to sit in an empty room, bored silly for 2 hours each time. It did nothing for my depression, suicidal ideation, or panic attacks. Giving me bad-tasting saline would have the same effects as esketamine (and be much cheaper). I think it works purely on a placebo effect! I also haven't responded to numerous antidepressants, CBT, or any other treatments either."

• Joh...
• Taken for 1 to 6 months
• December 15, 2020

Esketamine for Major Depressive Disorder "Once the sedative effects are no longer felt, you go back to being able to suppress your thoughts that you don't want to think about. It worked until my body got used to it."