Deplin Alternatives Compared
| Deplin | Rexulti | Vortioxetine |
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| Deplin (l-methylfolate) | Rexulti (brexpiprazole) | Vortioxetine |
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Prescription only
Prescribed for Folic Acid Deficiency, Hyperhomocysteinemia, Depression. Deplin may also be used for purposes not listed in this medication guide. |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression. Most people experience some improvement in their symptoms within 1 to 2 weeks of starting... View more |
Prescription only
Vortioxetine may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibiting... View more |
Related suggestions Depression
Popular comparisons
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| More about Deplin (l-methylfolate) | More about Rexulti (brexpiprazole) | More about Vortioxetine | ||||||||
| Generic Status | ||||||||||
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No lower-cost generic available |
No lower-cost generic available |
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| Ratings & Reviews | ||||||||||
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Deplin has an average rating of 7.6 out of 10 from a total of 109 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 17% reported a negative effect. |
Rexulti has an average rating of 6.4 out of 10 from a total of 404 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 28% reported a negative effect. |
Vortioxetine has an average rating of 6.0 out of 10 from a total of 1436 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 33% reported a negative effect. |
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| Drug Class | ||||||||||
| Side Effects | ||||||||||
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See also: Deplin side effects in more detail. |
See also: Rexulti side effects in more detail. |
Commonly reported side effects include:
See also: vortioxetine side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Rexulti prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Form(s) Available | ||||||||||
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N/A |
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| Brand Names | ||||||||||
| Other l-methylfolate brands include: Denovo, Duleek-DP, Elfolate, L-Methylfolate Forte, XaQuil XR |
N/A |
Trintellix | ||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||
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N/A |
91 hours |
66 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||
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Category N
Not classified
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||
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A total of 25 drugs are known to interact with Deplin:
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A total of 541 drugs are known to interact with Rexulti:
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A total of 339 drugs are known to interact with vortioxetine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||
| First Approval Date | ||||||||||
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N/A |
July 10, 2015 |
September 30, 2013 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||
| Patient resources | ||||||||||
| Professional Resources | ||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.