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Deplin and Headaches: What Users Say

Headaches: mentioned by 4 users (3.5%)

Based on user experiences from 114 Deplin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 9.6%
depression 5.3%
headaches 3.5%

Reviews for Deplin

Showing 4 reviews tagged with "headaches". Clear filters to view all 114 reviews.
Commonly mentioned side effects
  • Gla...
  • Taken for less than 1 month
  • April 5, 2017

For Depression "I was struggling with major depression and OCD and tried several antidepressants before my endocrine doctor found out I had the gene mutation. The first dose of Deplin, 15 mg, was too much for me and I felt edgy and anxious. I then tried the 7.5 dosage and honestly felt like myself for the first time in months. Clarity, energy, and focus! One side effect was headaches, and then I went online to MTHFR.net and learned I needed to supplement with a few things to feel better. This has been an answer to prayer for me. I am on 2.5 mg of Lexapro and hope to get off of it in the next 6 months. Wish someone would have told me about this sooner!!"

8 / 10
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78 Report
  • jon...
  • November 12, 2016

For Depression "I am taking 225 mg of Lamictal for depression. The Dr. wanted me to try this along with the Lamictal. I took it once, at bedtime, and woke up with the worst headache I've had in my entire life, and it lasted all day. Also had very loud ringing in my ears, which lasted all day. Not good. Needless to say, I did not take it again, so I cannot comment on its effectiveness."

1 / 10
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31 Report
  • Sev...
  • Taken for less than 1 month
  • December 14, 2021

For Depression "I was so hopeful hearing about the possibilities of Deplin and depression. I've tried twice, once at 15 mg for about a week, and had bad headaches. My doctor suggested taking half (7.5 mg) the dose to see if my body would adjust at a lower dose, and unfortunately, it hasn't. In the early start, though, my mood was better, and I was sleeping restfully while on it for a short time. The headaches are like migraine severity. They start in the neck, up the back of my head, and towards my ears. They last for a few days, during which I have to take Aleve just to be able to manage the pain. It would have been great to see if this would continue to improve my depression, but it's definitely not worth the painful side effects I experience."

4 / 10
Was this helpful?YesNo
7 Report
  • Sev...
  • Taken for less than 1 month
  • December 14, 2021

For Depression "I was so hopeful hearing about the possibilities of Deplin and depression. I've tried twice, once at 15 mg for about a week, and had bad headaches. My doctor suggested taking half (7.5 mg) the dose to see if my body would adjust at a lower dose, and unfortunately, it hasn't. In the early start, though, my mood was better, and I was sleeping restfully while on it for a short time. The headaches are like migraine severity. They start in the neck, up the back of my head, and towards my ears. They last for a few days, during which I have to take Aleve just to be able to manage the pain. It would have been great to see if this would continue to improve my depression, but it's definitely not worth the painful side effects I experience."

4 / 10
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7 Report

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