Comparing Cyproheptadine vs Hydroxyzine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Cyproheptadine	Hydroxyzine	Enter another drug to compare

Cyproheptadine

Hydroxyzine

Prescription only

Prescribed for Anorexia, Allergic Rhinitis, Allergic Reactions, Allergies, Anorexia Nervosa, Cluster Headaches, Cushing's Syndrome, Failure to Thrive, Migraine, Pruritus, Sexual Dysfunction - SSRI... View more

Prescription only

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

More about Cyproheptadine

More about Hydroxyzine

Ratings & Reviews

Cyproheptadine has an average rating of 8.2 out of 10 from a total of 212 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 10% reported a negative effect.

Hydroxyzine has an average rating of 5.9 out of 10 from a total of 1406 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 35% reported a negative effect.

View all 212 reviews

View all 1406 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (17.5%)
Sleepy (15.1%)
Weight gain (12.3%)
Tiredness (8.0%)
Increased appetite (6.6%)
Headaches (3.3%)
Nausea (2.8%)

View all Cyproheptadine side effects

Drowsiness (21.8%)
Tiredness (10.5%)
Sleepy (6.3%)
Anxiety (5.6%)
Nausea (3.8%)
Dizziness (3.7%)
Dry mouth (3.1%)

View all Hydroxyzine side effects

Drug Class

Antihistamines

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	4 mg
Per unit^*	$0.51
Cost^*	$25.48

View all Cyproheptadine prices

Quantity	4 tablet
Strength	hydrochloride 25 mg
Per unit^*	$2.74
Cost^*	$10.95

View all Hydroxyzine prices

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Dosage Forms

Oral syrup
Oral tablet

Intramuscular solution
Oral capsule
Oral syrup
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

16 hours

7 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 327 drugs are known to interact with Cyproheptadine:

10 major drug interactions (78 brand and generic names)
315 moderate drug interactions (1382 brand and generic names)
2 minor drug interactions (8 brand and generic names)

A total of 581 drugs are known to interact with Hydroxyzine:

93 major drug interactions (368 brand and generic names)
484 moderate drug interactions (1992 brand and generic names)
4 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of cyproheptadine such as dizziness... View more

Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

October 17, 1961

April 12, 1956

WADA Class View classifications

N/A

More Information

Patient Resources

Cyproheptadine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Cyproheptadine vs Hydroxyzine

See also:

Ubrelvy

Nurtec ODT

Qulipta

Xolair

Zyrtec

Celebrex

Benadryl

Flonase

Claritin

Singulair

Further information

Comparing Cyproheptadine vs Hydroxyzine

See also:

Further information

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