Comparing Cymbalta vs Prozac

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Cymbalta duloxetine

Prozac fluoxetine

Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more

Prozac may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder... View more

Prescription only

Ratings & Reviews

View all 1590 reviews

View all 1074 reviews

Drug Class

Serotonin-norepinephrine reuptake inhibitors

Selective serotonin reuptake inhibitors

Side Effects

Common side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, and xerostomia.

See the full Cymbalta side effects document.

See the full Prozac side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	21 delayed release capsule
Dosage	60 mg
Per Unit^*	$11.61
Cost^*	$243.73

View all Cymbalta prices and generic prices

Quantity	30 capsule
Dosage	20 mg
Per Unit^*	$17.85
Cost^*	$535.36

View all Prozac prices and generic prices

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Generic Availability

Yes

Dosage Form(s) Available

Oral delayed release capsule

Oral capsule

Brand Names

Other duloxetine brands include: Drizalma Sprinkle, Irenka

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

17 hours

210 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 565 drugs are known to interact with Cymbalta:

101 major drug interactions (451 brand and generic names)
441 moderate drug interactions (1918 brand and generic names)
23 minor drug interactions (179 brand and generic names)

A total of 637 drugs are known to interact with Prozac:

148 major drug interactions (567 brand and generic names)
467 moderate drug interactions (1964 brand and generic names)
22 minor drug interactions (94 brand and generic names)

Alcohol/Food/Lifestyle Interactions

DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more

Alcohol can increase the nervous system side effects of FLUoxetine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

N/A

December 29, 1987

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Professional Resources

Prescribing Information

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer