Comparing Cymbalta vs Prozac
Cymbaltaduloxetine |
Prozacfluoxetine |
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Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Chronic Pain,... more |
Prozac may be used for the treatment of depression and other mood disorders. It is more likely to cause insomnia than drowsiness. Prescribed for Anxiety and Stress, Major Depressive Disorder,... more |
Choose a suggestion belowDepression
Major Depressive Disorder
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.6
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7.4
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Drug Class |
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Side Effects |
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Common side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, and xerostomia. See the full Cymbalta side effects document. |
See the full Prozac side effects document. |
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Pricing and Coupons* Prices are without insurance |
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Generic Availability |
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Dosage Form(s) Available |
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Brand Names |
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Other duloxetine brands include: Irenka | Other fluoxetine brands include: Prozac Weekly, Rapiflux, Sarafem, Selfemra | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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17 hours |
210 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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FDA Alerts |
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Drug Interactions |
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A total of 1121 drugs are known to interact with Cymbalta:
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A total of 1137 drugs are known to interact with Prozac:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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N/A |
December 29, 1987 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Depression Have had back pain for years. Was on prescribed pain meds for years too. No longer on pain meds for about a year now but use kratom some. Prescribed Celexa for several years and seemed to stop working. My doctor put me on 60mg Cymbalta a couple months ago. No real side effects and It seems to put me in a better mood that I haven't experienced in many many years. I think the prior pain med and recreational drugs turned against. I feel more "corrected", clearer minded and content on the Cymbalta.