Comparing Cimetidine vs Nexium

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Cimetidine	Nexium (esomeprazole)	Enter another drug to compare

Cimetidine

Nexium (esomeprazole)

Prescription and OTC

Prescribed for Duodenal Ulcer, Cutaneous Mastocytosis, GERD, Bronchogenic Carcinoma, Duodenal Ulcer Prophylaxis, Erosive Esophagitis, Human Papilloma Virus, Indigestion, Laryngopharyngeal Reflux... View more

Prescription only

Nexium is an acid-suppressing agent used to treat conditions associated with excessive stomach acid production, such as gastroesophageal reflux (GERD) and stomach ulcers. Nexium is available orally... View more

More about Cimetidine

More about Nexium (esomeprazole)

Ratings & Reviews

Cimetidine has an average rating of 7.7 out of 10 from a total of 21 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 19% reported a negative effect.

Nexium has an average rating of 6.2 out of 10 from a total of 211 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 33% reported a negative effect.

View all 21 reviews

View all 211 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Cimetidine side effects

Anxiety (11.8%)
Diarrhea (11.4%)
Nausea (10.0%)
Headaches (9.0%)
Fatigue (7.1%)
Dizziness (5.7%)
Heart palpitations (5.7%)

View all Nexium side effects

Drug Class

H2 antagonists

Proton pump inhibitors

Generic Availability

Lower cost generic

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	10 tablet
Strength	400 mg
Per unit^*	$1.82
Cost^*	$18.16

View all Cimetidine prices

Quantity	30 delayed release capsule
Strength	40 mg
Per unit^*	$10.13
Cost^*	$303.90

View all Nexium prices

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Dosage Forms

Oral liquid
Oral tablet

Oral delayed release capsule
Oral powder for reconstitution, delayed release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

2.5 hours

1.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 488 drugs are known to interact with Cimetidine:

42 major drug interactions (144 brand and generic names)
296 moderate drug interactions (1152 brand and generic names)
150 minor drug interactions (1825 brand and generic names)

A total of 217 drugs are known to interact with Nexium:

23 major drug interactions (62 brand and generic names)
160 moderate drug interactions (1298 brand and generic names)
34 minor drug interactions (187 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Food may interfere with the absorption of esomeprazole. Esomeprazole should be taken at least one... View more

Disease Interactions

First Approval Date

August 16, 1977

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Cimetidine uses

Nexium uses

Professional Resources

N/A

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Cimetidine vs Nexium

See also:

Protonix

Pepcid

Ozempic

Prilosec

Magnesium oxide

Calcium carbonate

Ranitidine

Lansoprazole

Sucralfate

Pantoprazole

Further information

Comparing Cimetidine vs Nexium

See also:

Further information

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