Comparing Benadryl vs Tylenol PM
| Benadryl (diphenhydramine) | Tylenol PM (acetaminophen / diphenhydramine) |
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| Benadryl (diphenhydramine) | Tylenol PM (acetaminophen / diphenhydramine) |
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Prescription and OTC
Benadryl is used to treat allergies, motion sickness, and to relieve symptoms of Parkinson's Disease (PD) in patients unable to tolerate more potent agents. It may also be used off-label to help... View more |
Over-the-counter
Prescribed for Insomnia, Headache, Pain. Tylenol PM may also be used for purposes not listed in this medication guide. |
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| More about Benadryl (diphenhydramine) | More about Tylenol PM (acetaminophen / diphenhydramine) | ||||||||
| Ratings & Reviews | |||||||||
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Benadryl has an average rating of 7.0 out of 10 from a total of 80 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
Tylenol PM has an average rating of 5.4 out of 10 from a total of 36 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 42% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Benadryl side effects |
View all Tylenol PM side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||
View all Benadryl prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
| Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Other acetaminophen / diphenhydramine brands include: Acetadryl, Acetaminophen PM Extra Strength, Anacin PM Aspirin Free, Bayer Select Max Strength Night Time Pain, ConRx PM, Counteract PM Extra Strength, Excedrin PM, Genapap PM, Headache Formula PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Non-Aspirin PM Extra Strength, Pain Reliever PM, Percogesic Extra Strength, Percogesic Original Strength, Pharbetol PM, Robitussin Honey Severe Cough, Flu + Sore Throat CF Max Nighttime, Tylenol Sore Throat Nighttime, Unisom PM Pain, Wal-Nadol PM Extra Strength View more | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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9.3 hours |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 449 drugs are known to interact with Benadryl:
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A total of 560 drugs are known to interact with Tylenol PM:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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March 04, 1946 |
N/A |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
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N/A |
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| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.