Comparing Apremilast vs Humira

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Apremilast	Humira (adalimumab)	Enter another drug to compare

Apremilast

Humira (adalimumab)

Prescription only

Apremilast is a PDE4 inhibitor that may be used to treat plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s Disease. It has been associated with severe diarrhea, nausea, a... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

More about Apremilast

More about Humira (adalimumab)

Ratings & Reviews

Apremilast has an average rating of 5.3 out of 10 from a total of 473 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 39% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 702 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 30% reported a negative effect.

View all 473 reviews

View all 702 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (29.2%)
Diarrhea (24.1%)
Nausea (24.1%)
Depression (8.0%)
Upset stomach (7.4%)
Fatigue (5.3%)
Vomiting (5.1%)

View all Apremilast side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Drug Class

Antirheumatics

Generic Availability

N/A

Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,700.02
Cost^*	$7,400.03

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Dosage Forms

N/A

Subcutaneous kit

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

9 hours

480 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 111 drugs are known to interact with Apremilast:

15 major drug interactions (44 brand and generic names)
94 moderate drug interactions (251 brand and generic names)
2 minor drug interactions (4 brand and generic names)

A total of 553 drugs are known to interact with Humira:

300 major drug interactions (870 brand and generic names)
244 moderate drug interactions (942 brand and generic names)
9 minor drug interactions (37 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

March 21, 2014

December 31, 2002

WADA Class View classifications

N/A

More Information

Patient Resources

Apremilast uses

Humira uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Apremilast vs Humira

See also:

Stelara

Taltz

Skyrizi

Vtama

Humira

Tremfya

Enbrel

Cosentyx

Remicade

Otezla

Further information

Comparing Apremilast vs Humira

See also:

Further information

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