Comparing Amitriptyline vs Tofranil
| Amitriptyline | Tofranil (imipramine) |
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| Amitriptyline | Tofranil (imipramine) |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Prescribed for Enuresis, Primary Nocturnal Enuresis, Pain, Depression. Tofranil may also be used for purposes not listed in this medication guide. |
Related suggestions Depression
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| More about Amitriptyline | More about Tofranil (imipramine) | ||||||||
| Ratings & Reviews | |||||||||
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Amitriptyline has an average rating of 7.6 out of 10 from a total of 1807 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect. |
Tofranil has an average rating of 7.6 out of 10 from a total of 16 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Amitriptyline side effects |
View all Tofranil side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||
View all Amitriptyline prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
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N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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16 hours |
20 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 717 drugs are known to interact with Amitriptyline:
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A total of 739 drugs are known to interact with Tofranil:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
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| First Approval Date | |||||||||
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April 07, 1961 |
May 22, 1984 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.