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Tapentadol and Pain: What Users Say

Brand names: Nucynta, Nucynta ER

Pain: mentioned by 15 users (3.4%)

Based on user experiences from 436 Tapentadol reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 9.9%
headaches 8.9%
dizziness 7.1%
drowsiness 6.7%
insomnia 6.7%
tiredness 5.0%
anxiety 4.6%
brain fog 3.9%
constipation 3.9%
pain 3.4%

Reviews for Tapentadol

Commonly mentioned side effects
  • bam...
  • August 4, 2010

Tapentadol for Pain "After chronic pain for 5 years (bursitis and fibromyalgia), I think I've found a medicine perfect for me. I take 50 mg three times a day; it has helped so much with the fibromyalgia fatigue/fog. I have more energy, feel less depressed, and actually wake up without horrible pain. In the past I have been on Oxycontin, MS-Contin, Hydrocodone, Fentanyl patches, and Dilaudid. Nucynta is helping more than all of the above and it's much different than a typical narcotic. I am pleased!"

8 / 10
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199 Report
  • jay...
  • Taken for 1 to 6 months
  • June 7, 2016

Tapentadol for Pain "This medication was terrible! It did nothing for my nerve pain or the pain in my lower back. My doctor wanted to try it, and I agreed, and it was a month's worth of mistake. I was in pain even when I took 2 50 mg at a time. I would say it's a medication that should be used in cases where you don't have a very high pain level. I wouldn't recommend it."

1 / 10
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39 Report
  • L2a...
  • Taken for 6 months to 1 year
  • January 5, 2020

Tapentadol for Pain "After having a benign brain tumor removed, I began suffering from horrible headaches and seizures. I fell and fractured 5 ribs and collapsed my lung. That’s when I was diagnosed with cluster headaches. I have tried so many different medications and treatments, nerve blocks, infusions, and ablation. My pain management doctor started me on Nucynta ER 250 2x daily, and when I have breakthrough pain, I have 2-50 mg I can take to manage the pain. It’s tolerable, and I do not wake up in agony anymore. I also use Emgality, a migraine medication, monthly. The combination of medications is working better than anything else. The only thing I can say is this medication is the most expensive medication I have ever paid for. I wonder what people with no insurance would do."

8 / 10
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21 Report

See also:

  • Ita...
  • July 22, 2016

Tapentadol for Diabetic Peripheral Neuropathy "My stepdad was using this medication for less than two weeks before the pill itself killed him, proof is in the death certificate. He was not abusing either. He complained from day one of taking it of many side effects. Sleeplessness, dizziness, trouble urinating, hallucinations, still felt pain, couldn't stand without falling, etc. He asked his doctor to be off the pill, and they told him to wait until they see him the following month. Also, fault in their practice too."

1 / 10
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30 Report
  • wea...
  • Taken for less than 1 month
  • August 20, 2017

Tapentadol for Pain "I was switched to Nucynta 75 mg three daily from Norco 10 four daily and was told there would not be withdrawal effects. Either the doctor does not know or she lied. The withdrawal from Norco was fast and severe. Became very agitated and the pain spread and became worse. Dangerous drug."

1 / 10
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26 Report

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  • Max...
  • Taken for 1 to 6 months
  • March 4, 2019

For Pain "Tapentadol - I was on tapentadol for 4 months after breaking my neck in a bike accident. While on the drug, it did a great job of controlling my pain. The issue I had was coming off it. The sheer pain and anxiety with coming off the drug was horrible. I could not sleep for days, and the onset of nerve pain was intense. Never again."

7 / 10
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14 Report
  • Wil...
  • Taken for 1 to 6 months
  • April 23, 2019

For Pain "I have been taking OxyContin for over 10 years, 60 mg a day. Tried tapentadol over a six-month period. Caused sleep problems, chest pain, severe headaches, red face, pain in legs, and very little pain relief, 300 mg a day. Did not work for me, so going back to the OxyContin."

1 / 10
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14 Report
  • Dia...
  • Taken for less than 1 month
  • November 29, 2018

For Pain "This is the worst drug ever. I was prescribed it for my chronic lower back pain. The first 2 rounds were great for pain relief. The 3rd round was the worst. My back pain was so bad I could hardly move after getting out of bed until I took my next dose, then the pain went. The next morning it was back pain, wrist, knee, ankle, and finger pain. It was awful. I can see how people can get hooked on this poison if they aren't aware of what is going on. I have never experienced pain like it, even before my first back surgery. Stay off this stuff!! Google before you use it if you absolutely have to take it."

1 / 10
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14 Report
  • Dia...
  • Taken for less than 1 month
  • November 29, 2018

For Pain "This is the worst drug ever. I was prescribed it for my chronic lower back pain. The first 2 rounds were great for pain relief. The 3rd round was the worst. My back pain was so bad I could hardly move after getting out of bed until I took my next dose, then the pain went. The next morning it was back pain, wrist, knee, ankle, and finger pain. It was awful. I can see how people can get hooked on this poison if they aren't aware of what is going on. I have never experienced pain like it, even before my first back surgery. Stay off this stuff!! Google before you use it if you absolutely have to take it."

1 / 10
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14 Report
  • Dia...
  • Taken for less than 1 month
  • November 29, 2018

For Pain "This is the worst drug ever. I was prescribed it for my chronic lower back pain. The first 2 rounds were great for pain relief. The 3rd round was the worst. My back pain was so bad I could hardly move after getting out of bed until I took my next dose, then the pain went. The next morning it was back pain, wrist, knee, ankle, and finger pain. It was awful. I can see how people can get hooked on this poison if they aren't aware of what is going on. I have never experienced pain like it, even before my first back surgery. Stay off this stuff!! Google before you use it if you absolutely have to take it."

1 / 10
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14 Report
  • MS ...
  • Taken for 1 to 6 months
  • November 8, 2016

Tapentadol for Pain "I have a herniated disc and arachnoiditis, degenerative arthritis in the upper spine and left hip. I have had three meniscus repairs and the replacement of my left knee. I need the right knee replaced when possible. I have also had a disc fused in my neck. I am on Nucynta ER 50 mg twice a day, Percocet 7.5 mg 5 times daily, plus Soma. I am still suffering a lot of pain in the 8-9 range most of the time. I get very little sleep because of the pain and burning. The Nucynta ER helps but I need something better than the Percocet... I hate the feeling it causes. I am waiting (jumping through hoops) for the insurance to approve a nerve stimulator implant and praying it will give me at least 50% relief. I have not tried the Nucynta IR, will ask the doctor."

6 / 10
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15 Report
  • Bac...
  • Taken for 1 to 6 months
  • September 5, 2020

For Pain "Tapentadol slow release was generally effective in managing moderate to severe pain after a radio frequency nerve ablation of medial nerves from my lumbar facet joints. It was easy enough to step down from 200 to 150 to 100 mg after the procedure. But I quickly developed tolerance, meaning the lower dose became ineffective almost immediately. I stepped off without major physical side effects (other than increased pain) but suffered from considerable exhaustion, anxiety, depression, and confusion for several days. I wouldn’t have made it through post-procedure recovery without this medication, but be wary."

8 / 10
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6 Report
  • Sun...
  • Taken for 1 to 6 months
  • April 30, 2022

For Pain "100 mg SR for me is the equivalent of 2 paracetamol. And this is a controlled drug that is supposedly addictive? I was given it at 200 mg post-total knee replacement with Endone for breakthrough pain, and I was popping those Endone 4 times daily. Now, 6 months post-surgery, but now I need my other knee replaced, so I have pain in that knee. I keep 100 mg SR on hand to have some days because, for me, if I have it every day, I build tolerance, and it loses the minor pain relief it does provide. Really poor pain relief for me. My GP has now given me Amitriptyline 20 mg to help with pain, which is an antidepressant often prescribed for pain. Not getting much pain relief but feeling a little happier. I wouldn’t recommend this product personally."

3 / 10
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3 Report
  • Pai...
  • October 18, 2018

For Pain "I take 100 mg 2X day with up to 3X day of Oxycodone. Car accident 1996 sustained a severe spine injury; burst fracture T-10, full compressed spine, fracture C-3, crushed pelvis that tore my hip off frame. I'm full of titanium hardware/fusion. I suffer terrible pain and was on Oxycodone 4X day, still hurting. My doctor suggested I try a time release. This has been a blessing; it helps a lot. I still require breakthrough meds between doses. Been on this regiment for several years and very satisfied with pain control. I accept I'll always hurt, but it's getting level down to bearable. However, I am again having trouble getting my prescriptions filled? They claimed it's a manufacturer issue again 10/17/18. Why is this happening? When I do not have my meds, it sets me back days due to pain level rises. I'm upset that I have to be sent all over my area to look for it. I finally have a regiment that works, but going to come off this because it's not a readily dependable medication."

8 / 10
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3 Report
  • Vic...
  • Taken for less than 1 month
  • March 25, 2018

For Pain "Just started this drug, and it makes me feel like I've had speed. I googled speed effects, and it's exactly the same. Still have pain, and I can't sleep at night. Does anyone else feel the same?"

4 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.