Skip to main content

Sodium hyaluronate and Pain: What Users Say (Page 4)

Brand names: Euflexxa, Durolane, Hyalgan, Gelsyn-3, Supartz, Supartz FX

Reviews for Sodium hyaluronate

Commonly mentioned side effects
  • Jea...
  • February 22, 2018

For Osteoarthritis "First injection on Friday. No pain. Could walk ok. Next day, real pain to walk. Scale 1-10 (9). I iced down and took ibuprofen for pain. Most pain when trying to walk. Now it's been 6 days, and I've canceled my scheduled 2 injections. I wonder if I will get back to where I was before the shot? I'm 83, female, healthy (retired nurse). I live alone, and it's painful to get around. I read the success stories and wonder what went wrong for me. I also have a sore throat and joints ache, and I am more easily annoyed with my little dogs, I've noticed. I wasn't advised that any pain like this may happen. I believe it should have been."

1 / 10
Was this helpful?YesNo
24 Report
  • LBa...
  • Taken for 1 to 6 months
  • January 28, 2020

For Osteoarthritis "I had a Durolane injection in both knees 6 weeks ago. I am 56 years old and have severe osteoarthritis in both knees. The doctor told me when I left to go about my life. I ended up on the couch for a week after. 6 weeks later, I feel like I have weights on the bottom of my legs, and my knee joints ache terribly, and my muscles hurt constantly. I am so sorry I ever got the injections!!!!"

2 / 10
Was this helpful?YesNo
20 Report
  • Jci...
  • Taken for 1 to 6 months
  • April 25, 2020

For Osteoarthritis "I had 3 x 5-shot Synvisc treatments. They started to work quickly, but from 4-6 months, it wore out. I noticed the injected fluid escaped from the knee down to my ankle in a few days. I had my Durolane on Feb 24, now it's in the 8th week, and the fluid started to escape to my ankle. The first 3 weeks, I had pain from the injection, too much fluid in the knee. But after the 6th week, my knee started to feel much more effects. I hope it lasts more than 6 months. If every Durolane shot lasts 6 months, then forget about knee replacement, which cuts out PCL and ACL for good. No baseball, soccer, tennis, jogging, basketball, hockey, volleyball, sports dancing, etc., forever after knee replacement. I gave 6 stars now, wait and see how much better this will be."

6 / 10
Was this helpful?YesNo
20 Report
  • Xan...
  • May 2, 2016

For Osteoarthritis "I had this before. Good experience. Help lasted 5 years. The only problem I have is to get 3 injections that are very, very painful. Don't understand why they don't give a local anesthetic before injection. Then I was getting Silvist injection, I love that because I only get one injection. My insurance company refused to pay for it. They are! I hope that one day they have to do this! Sorry, just my opinion. Doctors need to take a stand against these evil, cold insurance companies who refuse to treat the patient right instead of making them suffer. They aren't doctors, they know nothing about what I need. The people who run insurance companies have ice running through their veins, they are not human."

10 / 10
Was this helpful?YesNo
30 Report
  • CJM...
  • February 3, 2017

For Osteoarthritis "I'm 44 and have osteoarthritis in both knees with Baker's cysts. Was told due to my age to try this as opposed to more drastic measures. First shot was about equivalent to getting a cortisone shot in my knees, pressure but bearable discomfort. A little sore the next day, week 2 and 3 about the same. Now I did just get a cortisone shot 2 weeks before starting the Euflexxa, but I figure now I am about 10% of the pain I was feeling prior. I hope it's the Euflexxa and not the cortisone masking it. Knees feel better every day and still pop here and there. But movement is dramatically better. 6 weeks since my first shot and I'm impressed and happy with my decision."

10 / 10
Was this helpful?YesNo
25 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Car...
  • Taken for 2 to 5 years
  • May 24, 2019

For Osteoarthritis "I had an injection in my knee, and 6 days later, I had to have 30 cc’s of fluid drained from my knee. It helped with some of the pain. 4 days later, in the hospital due to continued pain. More fluid drained to be sent for testing to ensure there was no infection, which was extremely painful. Note: there was no infection. Received some great pain medicine to help ride it out. It took about 4 weeks to get back to a non-painful event. NEVER AGAIN!"

1 / 10
Was this helpful?YesNo
19 Report
  • Kim...
  • Taken for 1 to 6 months
  • May 10, 2018

For Osteoarthritis "3 injections. The 1st, not much change. The 2nd, a little better. The 3rd hurt and was painful, but after all was settled and done, my pain was alleviated a great deal. I'm a 49-year-old female with bone-to-bone arthritis and could barely walk. Now I'm good. I noticed, as time has passed, I'm a lot more active, and now I'm starting to go to the gym to lose weight and strengthen the muscles that support my knees. That way, when the Euflexxa wears off, I will be better able to manage my pain. I am one month down with my shots, and it's a 70/30, so I'm very happy with it. My doctor did state that since I am bone on bone, I had a 50/50 chance of it working or not. Well, grateful to say it works. Keep you posted in another few months! Great results so far."

8 / 10
Was this helpful?YesNo
21 Report
  • Kim...
  • Taken for 1 to 6 months
  • May 10, 2018

For Osteoarthritis "3 injections. The 1st, not much change. The 2nd, a little better. The 3rd hurt and was painful, but after all was settled and done, my pain was alleviated a great deal. I'm a 49-year-old female with bone-to-bone arthritis and could barely walk. Now I'm good. I noticed, as time has passed, I'm a lot more active, and now I'm starting to go to the gym to lose weight and strengthen the muscles that support my knees. That way, when the Euflexxa wears off, I will be better able to manage my pain. I am one month down with my shots, and it's a 70/30, so I'm very happy with it. My doctor did state that since I am bone on bone, I had a 50/50 chance of it working or not. Well, grateful to say it works. Keep you posted in another few months! Great results so far."

8 / 10
Was this helpful?YesNo
21 Report
  • KAD...
  • Taken for less than 1 month
  • January 29, 2020

For Osteoarthritis "My partner is suffering from this Durolane injection, and our insurance is now only covering this injection. I would like to know if anyone has had good results for these injections, and if yes, how long did you start feeling like the injection was working. I’m trying to figure out if we need to push for something else at this point. This injection isn't working and is causing more pain than before this injection was given. My partner has only had 1 set of injections on both of her knees, and I’m afraid for her to get a second set of injections. I would appreciate any advice as she is in serious pain and now can’t walk without pain."

2 / 10
Was this helpful?YesNo
18 Report
  • Kat...
  • Taken for 2 to 5 years
  • April 1, 2021

For Osteoarthritis "My first experience with Euflexxa was almost 2 years ago. It gave me the much-needed pain relief and joint flexibility to continue with my passions of trail riding, backpacking in the mountains and canyons, downhill and cross-country skiing. It also allowed me to sit for hours while paddling my kayak without knee stiffness and pain. As it is not a permanent solution, I did recently receive my 2nd series of 3 injections as the stiffness and creaky knee was starting to return. Already I feel great and have a wonderful, oiled gate instead of a rusty, creaky one. Thank you to all who helped develop this active life-returning medication."

10 / 10
Was this helpful?YesNo
14 Report
  • Bre...
  • Taken for less than 1 month
  • October 17, 2022

For Osteoarthritis "I had my first injection of Durolane after my health insurance decided it would not cover the cost of my previous injection of Monovisc (which, by the way, worked for me). I was immediately in pain and yelled out in pain (cursed actually) and was in so much pain I could hardly walk out of the office to my car (which, the whole time, crying to get to my car and on the way home). It’s been 4 days icing and having pain. I would NEVER recommend this medication to anyone. I had better movement before I got the injection and am so disappointed. I called my doctor immediately the day after, and they said it was normal (seriously not normal to me) to feel this way and to call them after the weekend. I hope it gets better, but I will fight with my insurance company to do better for me! I could only give a one but would say a negative about this medication. I should have looked it up before I trusted my doctor."

1 / 10
Was this helpful?YesNo
10 Report
  • Kne...
  • Taken for 1 to 2 years
  • February 7, 2019

For Osteoarthritis "I tried this a few times with both of my knees. Extremely painful injections, cost me $2k each time ($1k per knee). Should have gone on vacation with that money, would have been more beneficial. They didn't work, only made more pain for 2 weeks and nauseated."

2 / 10
Was this helpful?YesNo
22 Report
  • mmm...
  • Taken for less than 1 month
  • April 3, 2017

For Osteoarthritis "Left knee arthroscopic cleanup. Still bad. Steroid injection relief for a couple of months. Another injection with fluid removed and same. Can walk on even ground with little to no pain. Cannot go up stairs still, so try Euflexxa. After the first of three shots, I am in pain walking on even ground now. Worse. Back does not hurt, just knee on standing or walking. Don't know what the surgeon will do about this. This knee looked salvageable, so no replacement offered yet. Ironically, the other knee is totally bone on bone but has no pain. Was hoping to get through summer without big surgery."

1 / 10
Was this helpful?YesNo
25 Report
  • VA ...
  • Taken for less than 1 month
  • April 25, 2023

For Osteoarthritis "Like others have stated, insurance switched this year and would not approve Synvisc, which worked beautifully for me the last few years. I get an injection about every 10 months. The day of the injection felt fine, just some swelling. Day 2, I can barely walk and my knee is swollen, and it's painful. My face, neck, and chest are bright red. None of this happened with Synvisc."

1 / 10
Was this helpful?YesNo
8 Report
  • MrB...
  • November 9, 2011

For Osteoarthritis "My doctor recommended Euflexxa in a severely arthritic left knee after 18 months of cortisone shots. The cortisone worked very well, but there were concerns about using it 'long term.' I had 3 rounds of shots, with the last round 5 weeks ago. I have more pain now than before the shots. I am woken more at night with pain and have more constant pain throughout the day. The only benefit from the Euflexxa is a mild increased tolerance for kneeling."

2 / 10
Was this helpful?YesNo
36 Report
  • Pai...
  • Taken for less than 1 month
  • July 8, 2022

For Osteoarthritis "I received Durolane in both knees almost 2 weeks ago. Most of the time, it feels like my right knee has been beaten by a sledgehammer. Both knees hurt worse than before I walked into the doctor’s office. I’m so disappointed by these painful results. I figured I’d see relief after a few days. Instead, I have pain at night and trouble sleeping. Right now, just sitting in a chair, typing this complaint, my right knee is killing me. Stairs are next to impossible, and I’d like to be able to get off a chair or a couch without looking like an invalid. Why this drug was ever approved is beyond me."

1 / 10
Was this helpful?YesNo
10 Report
  • PKa...
  • Taken for less than 1 month
  • February 11, 2022

For Osteoarthritis "DO NOT do Durolane unless you like extreme pain. I can’t believe I didn’t research this drug before my injection today. I totally trusted my doctor that recommended it and I know better. I have had Synvisc in my other knee years ago and no problem. I thought this would be similar. It is not. Horrible pain during the injection and could barely walk out of the office. Now about 12 hours since, I am using a walker to get to the bathroom, and that is even difficult. I can’t straighten my leg. I wish patients could post updates as to how long this pain lasts. I have tried ice, compression, elevation. Pain is horrible - I regret getting this. Will probably look for a new ortho. No one should go through this pain."

1 / 10
Was this helpful?YesNo
11 Report
  • Muf...
  • Taken for 1 to 6 months
  • May 25, 2019

For Osteoarthritis "I got an injection of Durolane in March on my right knee for a meniscus tear, and I am much worse. I cannot walk without pain. I will never get this shot again. Very disappointed. Durolane made my knee pain worse."

1 / 10
Was this helpful?YesNo
19 Report
  • DHP...
  • Taken for 1 to 2 years
  • July 29, 2024

For Osteoarthritis "I have had two Durolane injections in my right knee. The injections were the most painful thing I have ever experienced, and I almost passed out both times. However, after I recovered from the actual injection, they worked great, no pain in my knee for almost 6 months each time. That being said, I will not have another one as the fear of the pain of the injection is worse than the fear of the knee replacement surgery."

5 / 10
Was this helpful?YesNo
4 Report
  • in...
  • Taken for 1 to 6 months
  • April 6, 2017

For Osteoarthritis "First injection, no pain, second hurt, and third injection had me in tears! Still no relief from pain and burning in my knee. Both knees are bone on bone, no cartilage left. Two more injections to go, but not real optimistic at this point. :("

4 / 10
Was this helpful?YesNo
21 Report
  • ras...
  • Taken for less than 1 month
  • January 24, 2020

For Osteoarthritis "Some 3 weeks ago, I put up a review saying how bad the pain was. I made a call to have some physio, which included ultrasound - this took the pain to a whole new level. It was unlike any pain I had ever experienced. My recommendation is just let the injection do its work, do not have any physio. I have been taking Tramadol pain relievers to help manage the challenge - it is now 22 days post the injection, and the knee has 'really improved'. The way it is going, I will be able to start walking again, something that I have not done for a long, long while."

8 / 10
Was this helpful?YesNo
17 Report
  • Ann...
  • June 27, 2017

For Osteoarthritis "I played tennis 5 times a week for over 25 years of my life. This and arthritis since age 13 destroyed my knee caps and caused my left knee to deteriorate to bone-on-bone, and the bone marrow was bleeding out. I had the knee replaced and had a horrible recovery over 6 months and many months more for ankle and foot pain. Then my right knee became unbearable, and I decided to go for the gel. I had my first injection last Monday and felt better within the same day. Walking was less painful, swelling around the knee went down, I could sleep at night. I am very happy with the results so far, got another injection today, and I hope that this will continue. I am 75, had a new knee 12 years ago, and hip replacement recently."

10 / 10
Was this helpful?YesNo
20 Report
  • Deb...
  • April 16, 2018

For Osteoarthritis "I have had 3 injections of Euflexxa in both knees in a 2-year period. (Each treatment lasted approx 9 mos.) After each injection, I experienced swelling and some discomfort for approx 3 days, but rest and ice took care of it. 2 weeks after the 3rd injection, both times I could return to walking, climbing steps, and riding my bike with no mobility issues or pain. I was so happy to have Euflexxa. Knee replacement is not an option for me due to a blood clotting disorder. Last week, I went in for my 1st injection in year 3. 12 hours after injections, I presented with pain, severe headaches, nausea, fever (100.8-101.6), chills, aches. I contacted the Dr. who said I was having a reaction to Euflexxa. The other 6 injections never did this. I am going on my 4th day of terrible side effects and have no idea how long this will last. The Dr. canceled my future injections. Before you try, question your Dr. on side effects and if you are high risk for an allergic reaction. It is not worth the risk."

2 / 10
Was this helpful?YesNo
18 Report
  • Anonymous
  • December 8, 2010

For Osteoarthritis "Immediate difference after the first shot - what a relief! Subtle differences after shots 2 and 3. Got my 6-month booster and was relatively pain-free for 1 full year. Doctor said I was a good candidate for Euflexxa because the arthritic damage was not too severe yet. Time to get another booster."

10 / 10
Was this helpful?YesNo
33 Report
  • G25...
  • Taken for 1 to 6 months
  • July 16, 2019

For Osteoarthritis "Female, 66 years old, OA both knees. Got no relief from cortisone injections, so doc recommended Euflexxa. 1st injection was painful, and no relief noted. 2nd was more painful, and instead of relief, joint pain was worse. 3rd injection was very painful, and I am now at 3 weeks after the last injection, and I’m feeling worse than before I started this. Joint pain in hips and knees, pain in calves down to ankles - getting worse every day. I was really hoping that this would be beneficial and be able to avoid surgery. I see the doc again in 2 weeks to discuss what’s next. I won’t do this again."

2 / 10
Was this helpful?YesNo
18 Report

See also:

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.