Sodium hyaluronate and Nausea: What Users Say

• joh...
• February 10, 2016

Sodium hyaluronate for Osteoarthritis "I am a 36-year-old male police officer and avid outdoor enthusiast. I had my 2nd ACL surgery in 2012. I am very active, and having constant knee pain was not an option. My doctor decided to try Orthovisc injections to help with the arthritis. The Orthovisc worked great. Unfortunately, my insurance required my doctor to switch to Euflexxa. After my first injection, I was in incredible pain. The second shot, my knee swelled, and the pain was unbearable. The third shot was even worse. I ran a fever, had nausea, headaches; basic flu-like symptoms. I have read a lot of the reviews on this website. It seems like patients either have good results or results like mine. I want future patients to be aware of the potential risks."

• But...
• Taken for less than 1 month
• December 1, 2018

Sodium hyaluronate for Osteoarthritis "I had injections in both the right and left knees at the same time. The right knee did okay, but the left knee was absolutely horrible. Within 4 hours of injections, I had the most horrific reaction. The pain was the most extreme pain. I had painkillers, and it would not relieve the pain. It was so bad I wanted to call an ambulance. The only reason I didn't was because my bedroom is upstairs, and I couldn't make the trip downstairs. I knew the only way the paramedics could get to me was by breaking a 1500-dollar door down. So I kept taking more painkillers, and finally, after 7 hours, I had relief. Since the injections, I have severe leg cramps in both legs, wow, over the top! Itching over my body, bad lower back pain, RLS, and nausea. This continues every day. My legs barely move. Before treatment, I was walking 2 1/2 miles daily, and I'm 65... obviously, I had a severe allergic reaction. Would not ever recommend."

• Ale...
• October 19, 2019

Sodium hyaluronate for Osteoarthritis "I have osteoarthritis, bone on bone, both knees. The pain in the right knee is worse than the left. I had no relief from a cortisone injection. The right knee was injected with Euflexxa. About 72 hours post-injection, I developed bruising and swelling in the area that was injected. I was nauseous, hot, and sweaty, but had no fever. The knee was extremely painful, with increased swelling. Nothing relieved the pain. The doctor aspirated fluid and sent it for analysis and sent me for blood work. Results were normal. My experience with Euflexxa has been a nightmare. I still have pain at night and cannot sleep, and there is a constant nagging pain in the area where injected that is hard and extends upward a few inches. The doctor cannot tell me what happened. He has referred me to a surgeon to discuss knee replacement. I am thoroughly depressed over the entire experience, not to mention the constant pain."

• Can...
• August 4, 2019

Sodium hyaluronate for Osteoarthritis "I had my first Gelsyn-3 shot 8-2-2019. I use a cane to walk. I know I had a bad headache, nausea, and my body hurt, I didn't feel like eating. My knee has no relief at all yet. Knee replacement is the last option. I pray that by the 2nd injection it will improve."

• Lor...
• Taken for less than 1 month
• January 8, 2020

Sodium hyaluronate for Osteoarthritis "I had a Durolane injection after 2 of another brand that went well. United Healthcare insisted on this one this time. 20 minutes after the injection, I had extreme nausea and a headache to the point of not seeing well. The pain is worse now than before any shots 2 years ago. I have no idea how to make the pain stop now."

• Dai...
• Taken for less than 1 month
• June 3, 2022

Sodium hyaluronate for Osteoarthritis "I had Durolane injections in both knees ten days ago. My side effects included nausea, headache, back pain, tingling. Now my knees ache and burn so badly every movement is excruciating. I can barely get around the house. At seventy-two years old, this is the WORST decision I’ve ever made. PLEASE, if you are thinking about getting Durolane injections, don’t. Once it’s done, there’s no going back."

• Kne...
• Taken for 1 to 2 years
• February 7, 2019

Sodium hyaluronate for Osteoarthritis "I tried this a few times with both of my knees. Extremely painful injections, cost me $2k each time ($1k per knee). Should have gone on vacation with that money, would have been more beneficial. They didn't work, only made more pain for 2 weeks and nauseated."

• Anonymous
• April 4, 2016

Sodium hyaluronate for Osteoarthritis "2nd injection in my knees and feel 35% less pain, but I am so ill. I'll inject in both knees each Friday, by Saturday at 5 pm I have outrageous headache, nausea, dizziness. Very tough through the night, vomiting. My stomach hurts. Continues all Sunday and Monday till around 1 pm. Two weeks in a row now and missed work because of it. Not sure if I can continue injections."

• Deb...
• April 16, 2018

Sodium hyaluronate for Osteoarthritis "I have had 3 injections of Euflexxa in both knees in a 2-year period. (Each treatment lasted approx 9 mos.) After each injection, I experienced swelling and some discomfort for approx 3 days, but rest and ice took care of it. 2 weeks after the 3rd injection, both times I could return to walking, climbing steps, and riding my bike with no mobility issues or pain. I was so happy to have Euflexxa. Knee replacement is not an option for me due to a blood clotting disorder. Last week, I went in for my 1st injection in year 3. 12 hours after injections, I presented with pain, severe headaches, nausea, fever (100.8-101.6), chills, aches. I contacted the Dr. who said I was having a reaction to Euflexxa. The other 6 injections never did this. I am going on my 4th day of terrible side effects and have no idea how long this will last. The Dr. canceled my future injections. Before you try, question your Dr. on side effects and if you are high risk for an allergic reaction. It is not worth the risk."

• Anonymous
• Taken for less than 1 month
• January 19, 2021

Sodium hyaluronate for Osteoarthritis "Had the Durolane injection 4 days ago. The injection was very painful, and within a few hours, I could not walk due to pain and had horrible nausea! Took 3 days for the pain to go back to pre-shot pain, but my stomach has not recovered. I have terrible heartburn, reflux, and diarrhea. Not fun. My doctor said it could take 4 to 6 weeks for the injection to work. Fingers crossed. I don't think I would have this one again. I thought it would be best because it was only one injection. Lesson learned!"

• Mia...
• September 9, 2016

Sodium hyaluronate for Osteoarthritis "I had my meniscus repaired last November after a fall the previous year. I had tried physical therapy, ice, heat, Celebrex for 9 months. I have arthritis, which is extremely painful. I received the first cortisone shot, which gave me wonderful relief for 6 weeks. Pain worsened, so I needed to have my knee drained on three separate occasions and more cortisone shots. My knee is still very swollen, at least twice the size of my other one. I got Euflexxa shots over a 3-week period. They were painful when administered. I experienced nausea and a headache after each shot, approximately thirty minutes after the injection. I didn't have any relief, unfortunately. My surgeon feels it's time for a knee replacement. I am happy for those who report success."

• LJA...
• Taken for 1 to 6 months
• October 28, 2019

Sodium hyaluronate for Osteoarthritis "I had the injection in my left knee. The same day, I experienced severe stomach pain, nausea, and vomiting. Two weeks later, the pain in my knee is still there. The cost of the injection was $535.00, to which 80% was covered by our health plan. The doctor advised me to get another shot in 6 months. That is NOT going to happen. I will look into other methods for the osteoarthritis."

• Str...
• Taken for less than 1 month
• March 25, 2023

Sodium hyaluronate for Osteoarthritis "The morning after I had the injection, I woke up with a headache and nausea. I spent the next 6 hours throwing up, dizzy, with chills, migraine, and sharp pains in my abdomen. Worst reaction I could have had. Today is day five post-shot, and still, I am unable to eat a full meal, severe bloating, cramping in my abdomen, and extreme fatigue. Worse, the doctor has not called to check on me after I got them on the phone on day 1 post-injection. Needless to say, I will not be getting any more shots nor using said doctor again."

• Euf...
• Taken for less than 1 month
• January 12, 2023

For Osteoarthritis "Getting the injection was not a bad experience, but the pain was pretty bad right after. I had some unpleasant side effects that included a severe headache, nausea, gastrointestinal symptoms, and felt like I had a virus. I notified the doctor's office of the unwanted side effects, and I was not able to get any more injections. I will find out if I get any results from the one injection in my right knee. My experience with this medication was not good for me."

• cob...
• March 23, 2021

Sodium hyaluronate for Osteoarthritis "Would never use this again. Still in pain in a week, with nausea for 4 days. Knee still swollen and can’t sleep in pain. I will go back to cortisone and be shaking... at least no pain."